Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 3970-3975

  Chen, Austin ^a   Campeau, Louis Charles ^a   Cauchon, Elizabeth ^a   Chefson, Amandine ^a   Ducharme, Yves ^a   Dubé, Daniel ^a   Falgueyret, Jean Pierre ^a   Fournier, Pierre André ^a   Gagné, Sébastien ^a   Grimm, Erich ^a   Han, Yongxin ^a   Houle, Robert ^a   Huang, Jing Qi ^a   Lacombe, Patrick ^a   Laliberté, Sébastien ^a   Lévesque, Jean François ^a   Liu, Susana ^a   MacDonald, Dwight ^a   MacKay, Bruce ^a   McKay, Dan ^a   Percival, M David ^a   Regan, Chris ^b   Regan, Hillary ^b   St Jacques, René ^a   Toulmond, Sylvie ^a   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anti hypertensive; Inhibitor; Renin

Indexed keywords

DIPYRONE; PIPERIDINE DERIVATIVE; RENIN INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG SCREENING; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHYMOSIN; DOGS; DRUG DESIGN; ENZYME INHIBITORS; HYPERTENSION; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; PYRIDONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS; RODENTIA;

EID: 79958695576     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.013     Document Type: Article

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