Plasticity in cortical motor upper-limb representation following stroke and rehabilitation: Two longitudinal multi-joint FMRI case-studies

Brain Topography

Volumn 25, Issue 2, 2012, Pages 205-219

  Stark, A ^a   Meiner, Z ^b   Lefkovitz, R ^b   Levin, N ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Homoncoulus; Imaging; Longitudinal; Primary motor cortex; Rehabilitation; Stroke

Indexed keywords

ADULT; ANKLE; ARTICLE; BRAIN REGION; CASE CONTROL STUDY; CASE REPORT; CLINICAL EVALUATION; CONSTRAINT INDUCED MOVEMENT THERAPY; CONTROLLED STUDY; ELBOW; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMIPARESIS; HUMAN; IMMOBILIZATION; LIMB MOVEMENT; LONGITUDINAL STUDY; MALE; MOTOR CONTROL; MOVEMENT THERAPY; NERVE CELL PLASTICITY; NEUROIMAGING; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; STROKE; TREATMENT DURATION; WRIST;

ADULT; ANKLE JOINT; CASE-CONTROL STUDIES; ELBOW JOINT; FEMALE; FUNCTIONAL LATERALITY; FUNCTIONAL NEUROIMAGING; HUMANS; JOINTS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTOR CORTEX; NEURONAL PLASTICITY; PARESIS; PHYSICAL THERAPY MODALITIES; RECOVERY OF FUNCTION; STROKE; UPPER EXTREMITY; WRIST JOINT;

EID: 84862769062     PISSN: 08960267     EISSN: 15736792     Source Type: Journal    
DOI: 10.1007/s10548-011-0201-2     Document Type: Article

References (61)

1. Blankenburg F, Ruben J, Meyer R, Schwiemann J, Villringer A (2003) Evidence for a rostral-to-caudal somatotopic organization in human primary somatosensory cortex with mirror-reversal in areas 3b and 1. Cereb Cortex 13(9):987-993 (Pubitemid 37064836)
2. Boake C, Noser EA, Ro T, Baraniuk S, Gaber M, Johnson R, Salmeron ET, Tran TM, Lai JM, Taub E, Moye LA, Grotta JC, Levin HS (2007) Constraint-induced movement therapy during early stroke rehabilitation. Neurorehabil Neural Repair 21(1): 14-24 (Pubitemid 44926968)
3. Butefisch CM, Wessling M, Netz J, Seitz RJ, Homberg V (2008) Relationship between interhemispheric inhibition and motor cortex excitability in subacute stroke patients. Neurorehabil Neural Repair 22(1):4-21 (Pubitemid 350223133)
4. Calautti C, Baron JC (2003) Functional neuroimaging studies of motor recovery after stroke in adults: a review. Stroke 34(6): 1553-1566 (Pubitemid 36693533)
5. Calautti C, Naccarato M, Jones PS, Sharma N, Day DD, Carpenter AT, Bullmore ET, Warburton EA, Baron JC (2007) The relationship between motor deficit and hemisphere activation balance after stroke: a 3T fMRI study. Neuroimage 34(1): 322-331 (Pubitemid 44773795)
6. Cao Y, D'Olhaberriague L, Vikingstad EM, Levine SR, Welch KM (1998) Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis. Stroke 29(1): 112-122 (Pubitemid 28046951)
7. Carey JR, Kimberley TJ, Lewis SM, Auerbach EJ, Dorsey L, Rundquist P, Ugurbil K (2002) Analysis of fMRI and finger tracking training in subjects with chronic stroke. Brain 125(Pt 4):773-788 (Pubitemid 34279773)
8. Chouinard PA, Leonard G, Paus T (2006) Changes in effective connectivity of the primary motor cortex in stroke patients after rehabilitative therapy. Exp Neurol 201(2):375-387 (Pubitemid 44344230)
9. Cohen LG, Bandinelli S, Findley TW, Hallett M (1991) Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation. Brain 114(Pt 1B):615-627
10. Cramer SC, Riley JD (2008) Neuroplasticity and brain repair after stroke. Curr Opin Neurol 21(1):76-82
11. Darian-Smith C (2009) Synaptic plasticity, neurogenesis, and functional recovery after spinal cord injury. Neuroscientist 15(2): 149-165
12. Darian-Smith C, Brown S (2000) Functional changes at periphery and cortex following dorsal root lesions in adult monkeys. Nat Neurosci 3(5):476-481 (Pubitemid 30495630)
13. Darian-Smith C, Ciferri MM (2005) Loss and recovery of voluntary hand movements in the macaque following a cervical dorsal rhizotomy. J Comp Neurol 491(1):27-45 (Pubitemid 41254613)
14. Devanne H, Cassim F, Ethier C, Brizzi L, Thevenon A, Capaday C (2006) The comparable size and overlapping nature of upper limb distal and proximal muscle representations in the human motor cortex. Eur J Neurosci 23(9):2467-2476 (Pubitemid 43742877)
15. Dijkhuizen RM, Ren J, Mandeville JB, Wu O, Ozdag FM, Moskowitz MA, Rosen BR, Finklestein SP (2001) Functional magnetic resonance imaging of reorganization in rat brain after stroke. Proc Natl Acad Sci USA 98(22):12766-12771 (Pubitemid 33020019)
16. Dong Y, Dobkin BH, Cen SY, Wu AD, Winstein CJ (2006) Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke. Stroke 37(6):1552-1555 (Pubitemid 44305742)
17. Donoghue JP, Leibovic S, Sanes JN (1992) Organization of the forelimb area in squirrel monkey motor cortex: representation of digit, wrist, and elbow muscles. Exp Brain Res 89(1):1-19
18. Fries W, Danek A, Scheidtmann K, Hamburger C (1993) Motor recovery following capsular stroke. Role of descending pathways from multiple motor areas. Brain 116(Pt 2):369-382 (Pubitemid 23104053)
19. Fugl-Meyer AR, Jaasko L, Leyman I, Olsson S, Steglind S (1975) The post-stroke hemiplegic patient. 1. A method for evaluation of physical performance. Scand J Rehabil Med 7(1):13-31
20. Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M (2006) Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 129(Pt 3):791-808 (Pubitemid 43278240)
21. Hamzei F, Liepert J, Dettmers C, Weiller C, Rijntjes M (2006) Two different reorganization patterns after rehabilitative therapy: an exploratory study with fMRI and TMS. Neuroimage 31(2): 710-720 (Pubitemid 43776661)
22. Hlustik P, Solodkin A, Gullapalli RP, Noll DC, Small SL (2001) Somatotopy in human primary motor and somatosensory hand representations revisited. Cereb Cortex 11(4):312-321 (Pubitemid 32249696)
23. Indovina I, Sanes JN (2001) On somatotopic representation centers for finger movements in human primary motor cortex and supplementary motor area. Neuroimage 13(6 Pt 1):1027-1034 (Pubitemid 32553533)
24. Jansen A, Menke R, Sommer J, Forster AF, Bruchmann S, Hempleman J, Weber B, Knecht S (2006) The assessment of hemispheric lateralization in functional MRI-robustness and reproducibility. Neuroimage 33(1):204-217 (Pubitemid 44397590)
25. Johansen-Berg H, Dawes H, Guy C, Smith SM, Wade DT, Matthews PM (2002) Correlation between motor improvements and altered fMRI activity after rehabilitative therapy. Brain 125(Pt 12): 2731-2742 (Pubitemid 35423522)
26. Kleinschmidt A, Nitschke MF, Frahm J (1997) Somatotopy in the human motor cortex hand area. A high-resolution functional MRI study. Eur J Neurosci 9(10):2178-2186 (Pubitemid 27485249)
27. Knapp HD, Taub E, Berman AJ (1963) Movements in monkeys with deafferented forelimbs. Exp Neurol 7:305-315
28. Kwan HC, MacKay WA, Murphy JT, Wong YC (1978) Spatial organization of precentral cortex in awake primates. II. Motor outputs. J Neurophysiol 41(5):1120-1131 (Pubitemid 9011383)
29. Liepert J, Tegenthoff M, Malin JP (1995) Changes of cortical motor area size during immobilization. Electroencephalogr Clin Neurophysiol 97(6):382-386 (Pubitemid 26019395)
30. Liepert J, Bauder H, Wolfgang HR, Miltner WH, Taub E, Weiller C (2000) Treatment-induced cortical reorganization after stroke in humans. Stroke 31(6):1210-1216 (Pubitemid 30351235)
31. Mark VW, Taub E, Morris DM (2006) Neuroplasticity and constraintinduced movement therapy. Eura Medicophys 42(3):269-284
32. Meier JD, Aflalo TN, Kastner S, Graziano MS (2008) Complex organization of human primary motor cortex: a high-resolution fMRI study. J Neurophysiol 100(4):1800-1812
33. Morris DM, Taub E, Mark VW (2006) Constraint-induced movement therapy: characterizing the intervention protocol. Eura Medicophys 42(3):257-268 (Pubitemid 46030368)
34. Nair DG, Hutchinson S, Fregni F, Alexander M, Pascual-Leone A, Schlaug G (2007) Imaging correlates of motor recovery from cerebral infarction and their physiological significance in wellrecovered patients. Neuroimage 34(1):253-263 (Pubitemid 44802814)
35. Nudo RJ, Wise BM, SiFuentes F, Milliken GW (1996) Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science 272(5269):1791-1794 (Pubitemid 26256399)
36. Park MC, Belhaj-Saif A, Gordon M, Cheney PD (2001) Consistent features in the forelimb representation of primary motor cortex in rhesus macaques. J Neurosci 21(8):2784-2792 (Pubitemid 32298219)
37. Pascual-Leone A, Peris M, Tormos JM, Pascual AP, Catala MD (1996) Reorganization of human cortical motor output maps following traumatic forearm amputation. Neuroreport 7(13): 2068-2070 (Pubitemid 26361817)
38. Penfield W, Rasmussen T (1950) The cerebral cortex of man. Macmillan, New York
39. Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M (1991) Massive cortical reorganization after sensory deafferentation in adult macaques. Science 252(5014):1857-1860 (Pubitemid 21917112)
40. Rao SM, Binder JR, Hammeke TA, Bandettini PA, Bobholz JA, Frost JA, Myklebust BM, Jacobson RD, Hyde JS (1995) Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging. Neurology 45(5):919-924
41. Rossini PM, Calautti C, Pauri F, Baron JC (2003) Post-stroke plastic reorganisation in the adult brain. Lancet Neurol 2(8):493-502 (Pubitemid 36876106)
42. Sanes JN, Suner S, Lando JF, Donoghue JP (1988) Rapid reorganization of adult rat motor cortex somatic representation patterns after motor nerve injury. Proc Natl Acad Sci USA 85(6):2003-2007 (Pubitemid 24315813)
43. Sanes JN, Donoghue JP, Thangaraj V, Edelman RR, Warach S (1995) Shared neural substrates controlling hand movements in human motor cortex. Science 268(5218):1775-1777
44. Schaechter JD, Kraft E, Hilliard TS, Dijkhuizen RM, Benner T, Finklestein SP, Rosen BR, Cramer SC (2002) Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study. Neurorehabil Neural Repair 16(4):326-338 (Pubitemid 35375608)
45. Schieber MH (2001) Constraints on somatotopic organization in the primary motor cortex. J Neurophysiol 86(5):2125-2143 (Pubitemid 34000578)
46. Schieber MH, Hibbard LS (1993) How somatotopic is the motor cortex hand area? Science 261(5120):489-492 (Pubitemid 23276562)
47. Seghier ML (2008) Laterality index in functional MRI: methodological issues. Magn Reson Imaging 26(5):594-601
48. Serrien DJ, Strens LH, Cassidy MJ, Thompson AJ, Brown P (2004) Functional significance of the ipsilateral hemisphere during movement of the affected hand after stroke. Exp Neurol 190(2):425-432 (Pubitemid 39504997)
49. Sheng B, Lin M (2009) A longitudinal study of functional magnetic resonance imaging in upper-limb hemiplegia after stroke treated with constraint-induced movement therapy. Brain Inj 23(1):65-70
50. Sterr A, Elbert T, Berthold I, Kölbel S, Rockstroh B, Taub E (2002) Longer versus shorter daily constraint-induced movement therapy of chronic hemiparesis: an exploratory study. Arch Phys Med Rehabil 83(10):1374-1377
51. Szaflarski JP, Page SJ, Kissela BM, Lee JH, Levine P, Strakowski SM (2006) Cortical reorganization following modified constraintinduced movement therapy: a study of 4 patients with chronic stroke. Arch Phys Med Rehabil 87(8):1052-1058 (Pubitemid 44107843)
52. Taub E, Heitmann RD, Barro G (1977) Alertness, level of activity, and purposive movement following somatosensory deafferentation in monkeys. Ann N Y Acad Sci 290:348-365
53. Taub E, Miller NE, Novack TA, Cook EW 3rd, Fleming WC, Nepomuceno CS, Connell JS, Crago JE (1993) Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 74(4):347-354 (Pubitemid 23115348)
54. Taub E, Uswatte G, Mark VW, Morris DM (2006) The learned nonuse phenomenon: implications for rehabilitation. Eura Medicophys 42(3):241-256
55. van der Lee JH, Wagenaar RC, Lankhorst GJ, Vogelaar TW, Deville WL, Bouter LM (1999) Forced use of the upper extremity in chronic stroke patients: results from a single-blind randomized clinical trial. Stroke 30(11):2369-2375 (Pubitemid 29517737)
56. Vierck CJ Jr (1982) Comparison of the effects of dorsal rhizotomy or dorsal column transection on motor performance of monkeys. Exp Neurol 75(3):566-575 (Pubitemid 12185584)
57. Ward NS, Brown MM, Thompson AJ, Frackowiak RS (2003) Neural correlates of outcome after stroke: a cross-sectional fMRI study. Brain 126(Pt 6):1430-1448 (Pubitemid 36644387)
58. Wenzelburger R, Kopper F, Frenzel A, Stolze H, Klebe S, Brossmann A, Kuhtz-Buschbeck J, Golge M, Illert M, Deuschl G (2005) Hand coordination following capsular stroke. Brain 128(Pt 1):64-74 (Pubitemid 40070521)
59. Wittenberg GF, Chen R, Ishii K, Bushara KO, Eckloff S, Croarkin E, Taub E, Gerber LH, Hallett M, Cohen LG (2003) Constraintinduced therapy in stroke: magnetic-stimulation motor maps and cerebral activation. Neurorehabil Neural Repair 17(1): 48-57 (Pubitemid 37102027)
60. Wolf SL, Catlin PA, Ellis M, Archer AL, Morgan B, Piacentino A (2001) Assessing Wolf motor function test as outcome measure for research in patients after stroke. Stroke 32(7):1635-1639 (Pubitemid 32631916)
61. Wolf SL, Winstein CJ, Miller JP, Taub E, Uswatte G, Morris D, Giuliani C, Light KE, Nichols-Larsen D (2006) Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. Jama 296(17):2095-2104 (Pubitemid 44664704)