메뉴 건너뛰기




Volumn 6, Issue 12, 2011, Pages

DNasei hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; DEOXYRIBONUCLEASE I; EYE PROTEIN; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX6;

EID: 84855261984     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028616     Document Type: Article
Times cited : (53)

References (62)
  • 3
    • 11144339384 scopus 로고    scopus 로고
    • Long-range control of gene expression: emerging mechanisms and disruption in disease
    • Kleinjan DA, van Heyningen V, (2005) Long-range control of gene expression: emerging mechanisms and disruption in disease. Am J Hum Genet 76 (1): 8-32.
    • (2005) Am J Hum Genet , vol.76 , Issue.1 , pp. 8-32
    • Kleinjan, D.A.1    van Heyningen, V.2
  • 4
    • 70349611559 scopus 로고    scopus 로고
    • Cis-ruption mechanisms: disruption of cis-regulatory control as a cause of human genetic disease
    • Kleinjan DJ, Coutinho P, (2009) Cis-ruption mechanisms: disruption of cis-regulatory control as a cause of human genetic disease. Brief Funct Genomic Proteomic 8 (4): 317-332.
    • (2009) Brief Funct Genomic Proteomic , vol.8 , Issue.4 , pp. 317-332
    • Kleinjan, D.J.1    Coutinho, P.2
  • 5
    • 0026340588 scopus 로고
    • Pax-6, a murine paired box gene, is expressed in the developing CNS
    • Walther C, Gruss P, (1991) Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 113: 1435-1449.
    • (1991) Development , vol.113 , pp. 1435-1449
    • Walther, C.1    Gruss, P.2
  • 6
    • 0028207924 scopus 로고
    • Roles of Pax-genes in developing and adult brain as suggested by expression patterns
    • Stoykova A, Gruss P, (1994) Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci 14: 1395-1412.
    • (1994) J Neurosci , vol.14 , pp. 1395-1412
    • Stoykova, A.1    Gruss, P.2
  • 7
    • 0029002548 scopus 로고
    • The role of Pax-6 in eye and nasal development
    • Grindley JC, Davidson DR, Hill RE, (1995) The role of Pax-6 in eye and nasal development. Development 121: 1433-1442.
    • (1995) Development , vol.121 , pp. 1433-1442
    • Grindley, J.C.1    Davidson, D.R.2    Hill, R.E.3
  • 8
    • 0036844682 scopus 로고    scopus 로고
    • Pax6; a pleiotropic player in development
    • Simpson TI, Price DJ, (2002) Pax6; a pleiotropic player in development. Bioessays 24: 1041-1051.
    • (2002) Bioessays , vol.24 , pp. 1041-1051
    • Simpson, T.I.1    Price, D.J.2
  • 9
    • 0030918405 scopus 로고    scopus 로고
    • Roles of Pax-6 in murine diencephalic development
    • Warren N, Price DJ, (1997) Roles of Pax-6 in murine diencephalic development. Development 124: 1573-1582.
    • (1997) Development , vol.124 , pp. 1573-1582
    • Warren, N.1    Price, D.J.2
  • 10
    • 0034003392 scopus 로고    scopus 로고
    • Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas
    • Dohrmann C, Gruss P, Lemaire L, (2000) Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas. Mech Dev 92: 47-54.
    • (2000) Mech Dev , vol.92 , pp. 47-54
    • Dohrmann, C.1    Gruss, P.2    Lemaire, L.3
  • 11
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
    • St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P, (1997) Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387: 406-409.
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 12
    • 0034312313 scopus 로고    scopus 로고
    • Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    • Ashery-Padan R, Marquardt T, Zhou X, Gruss P, (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev 14 (21): 2701-2711.
    • (2000) Genes Dev , vol.14 , Issue.21 , pp. 2701-2711
    • Ashery-Padan, R.1    Marquardt, T.2    Zhou, X.3    Gruss, P.4
  • 13
    • 0029855582 scopus 로고    scopus 로고
    • Forebrain patterning defects in Small eye mutant mice
    • Stoykova A, Fritsch R, Walther C, Gruss P, (1996) Forebrain patterning defects in Small eye mutant mice. Development 122: 3453-3465.
    • (1996) Development , vol.122 , pp. 3453-3465
    • Stoykova, A.1    Fritsch, R.2    Walther, C.3    Gruss, P.4
  • 14
    • 0035147568 scopus 로고    scopus 로고
    • Pax6 regulates the identity of embryonic diencephalic neurons
    • Mastick GS, Andrews GL, (2001) Pax6 regulates the identity of embryonic diencephalic neurons. Mol Cell Neurosci 17: 190-207.
    • (2001) Mol Cell Neurosci , vol.17 , pp. 190-207
    • Mastick, G.S.1    Andrews, G.L.2
  • 15
    • 0032880081 scopus 로고    scopus 로고
    • The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortex
    • Warren N, Caric D, Pratt T, Clausen JA, Asavaritikrai P, et al. (1999) The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortex. Cereb Cortex 9: 627-635.
    • (1999) Cereb Cortex , vol.9 , pp. 627-635
    • Warren, N.1    Caric, D.2    Pratt, T.3    Clausen, J.A.4    Asavaritikrai, P.5
  • 16
    • 0033405043 scopus 로고    scopus 로고
    • Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
    • Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, et al. (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci USA; 96 (25): 14378-82.
    • (1999) Proc Natl Acad Sci USA; , vol.96 , Issue.25 , pp. 14378-14382
    • Kioussi, C.1    O'Connell, S.2    St-Onge, L.3    Treier, M.4    Gleiberman, A.S.5
  • 18
    • 0035815295 scopus 로고    scopus 로고
    • Pax6 is required for the multipotent state of retinal progenitor cells
    • Marquardt T, Ashery-Padan R, Andrejewski N, Scardigli R, Guillemot F, et al. (2001) Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105 (1): 43-55.
    • (2001) Cell , vol.105 , Issue.1 , pp. 43-55
    • Marquardt, T.1    Ashery-Padan, R.2    Andrejewski, N.3    Scardigli, R.4    Guillemot, F.5
  • 19
    • 0026315044 scopus 로고
    • Positional cloning and characterization of a paired box-containing and homeobox-containing gene from the aniridia region
    • Ton CCT, Hirvonen H, Miwa H, Weil MM, Monaghan P, et al. (1991) Positional cloning and characterization of a paired box-containing and homeobox-containing gene from the aniridia region. Cell 67: 1059-1074.
    • (1991) Cell , vol.67 , pp. 1059-1074
    • Ton, C.C.T.1    Hirvonen, H.2    Miwa, H.3    Weil, M.M.4    Monaghan, P.5
  • 20
    • 0022558958 scopus 로고
    • Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse
    • Hogan BL, Horsburgh G, Cohen J, Hetherington CM, Fisher G, et al. (1986) Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J Embryol Exp Morphol 97: 95-110.
    • (1986) J Embryol Exp Morphol , vol.97 , pp. 95-110
    • Hogan, B.L.1    Horsburgh, G.2    Cohen, J.3    Hetherington, C.M.4    Fisher, G.5
  • 21
    • 0026345992 scopus 로고
    • Mouse small eye results from mutations in a paired-like homeobox-containing gene
    • Hill RE, Favor J, Hogan BL, Ton CC, Saunders GF, et al. (1991) Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 354: 522-525.
    • (1991) Nature , vol.354 , pp. 522-525
    • Hill, R.E.1    Favor, J.2    Hogan, B.L.3    Ton, C.C.4    Saunders, G.F.5
  • 22
    • 0034938449 scopus 로고    scopus 로고
    • PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans
    • Sisodiya SM, Free SL, Williamson KA, Mitchell TH, Willis C, et al. (2001) PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans. Nature Genetics 28: 214-216.
    • (2001) Nature Genetics , vol.28 , pp. 214-216
    • Sisodiya, S.M.1    Free, S.L.2    Williamson, K.A.3    Mitchell, T.H.4    Willis, C.5
  • 23
    • 0030581164 scopus 로고    scopus 로고
    • Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities
    • Schedl A, Ross A, Lee M, Engelkamp D, Rashbass P, et al. (1996) Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell 86: 71-82.
    • (1996) Cell , vol.86 , pp. 71-82
    • Schedl, A.1    Ross, A.2    Lee, M.3    Engelkamp, D.4    Rashbass, P.5
  • 24
    • 33847395395 scopus 로고    scopus 로고
    • Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    • Manuel M, Georgala PA, Carr CB, Chanas S, Kleinjan DA, et al. (2007) Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development 134 (3): 545-555.
    • (2007) Development , vol.134 , Issue.3 , pp. 545-555
    • Manuel, M.1    Georgala, P.A.2    Carr, C.B.3    Chanas, S.4    Kleinjan, D.A.5
  • 25
    • 44949168456 scopus 로고    scopus 로고
    • Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    • Manuel M, Pratt T, Liu M, Jeffery G, Price DJ, (2008) Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol 8: 59.
    • (2008) BMC Dev Biol , vol.8 , pp. 59
    • Manuel, M.1    Pratt, T.2    Liu, M.3    Jeffery, G.4    Price, D.J.5
  • 26
  • 27
    • 17144471991 scopus 로고    scopus 로고
    • A highly conserved lens transcriptional control element from the Pax-6 gene
    • Williams SC, Altmann CR, Chow RL, Hemmati-Brivanlou A, Lang RA, (1998) A highly conserved lens transcriptional control element from the Pax-6 gene. Mech Dev 73 (2): 225-229.
    • (1998) Mech Dev , vol.73 , Issue.2 , pp. 225-229
    • Williams, S.C.1    Altmann, C.R.2    Chow, R.L.3    Hemmati-Brivanlou, A.4    Lang, R.A.5
  • 28
    • 0032895297 scopus 로고    scopus 로고
    • Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity
    • Kammandel B, Chowdhury K, Stoykova A, Aparicio S, Brenner S, et al. (1999) Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol 205: 79-97.
    • (1999) Dev Biol , vol.205 , pp. 79-97
    • Kammandel, B.1    Chowdhury, K.2    Stoykova, A.3    Aparicio, S.4    Brenner, S.5
  • 29
    • 0032942213 scopus 로고    scopus 로고
    • Regulation of Pax6 expression is conserved between mice and flies
    • Xu PX, Zhang X, Heaney S, Yoon A, Michelson AM, et al. (1999) Regulation of Pax6 expression is conserved between mice and flies. Development 126: 383-395.
    • (1999) Development , vol.126 , pp. 383-395
    • Xu, P.X.1    Zhang, X.2    Heaney, S.3    Yoon, A.4    Michelson, A.M.5
  • 30
    • 0034782502 scopus 로고    scopus 로고
    • Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6
    • Kleinjan DA, Seawright A, Schedl A, Quinlan RA, Danes S, et al. (2001) Aniridia-associated translocations, DNase hypersensitivity, sequence comparison and transgenic analysis redefine the functional domain of PAX6. Hum Mol Genet 10: 2049-2059.
    • (2001) Hum Mol Genet , vol.10 , pp. 2049-2059
    • Kleinjan, D.A.1    Seawright, A.2    Schedl, A.3    Quinlan, R.A.4    Danes, S.5
  • 31
    • 0036008319 scopus 로고    scopus 로고
    • New 3′ elements control Pax6 expression in the developing pretectum, neural retina and olfactory region
    • Griffin C, Kleinjan DA, Doe B, van Heyningen V, (2002) New 3′ elements control Pax6 expression in the developing pretectum, neural retina and olfactory region. Mech Dev 112: 89-100.
    • (2002) Mech Dev , vol.112 , pp. 89-100
    • Griffin, C.1    Kleinjan, D.A.2    Doe, B.3    van Heyningen, V.4
  • 32
    • 0347914540 scopus 로고    scopus 로고
    • Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription
    • Kleinjan DA, Seawright A, Childs AJ, van Heyningen V, (2004) Conserved elements in Pax6 intron 7 involved in (auto)regulation and alternative transcription. Dev Biol 265: 462-477.
    • (2004) Dev Biol , vol.265 , pp. 462-477
    • Kleinjan, D.A.1    Seawright, A.2    Childs, A.J.3    van Heyningen, V.4
  • 33
    • 33750350276 scopus 로고    scopus 로고
    • Long-range downstream enhancers are essential for Pax6 expression
    • Kleinjan DA, Seawright A, Mella S, Carr CB, Tyas DA, et al. (2006) Long-range downstream enhancers are essential for Pax6 expression. Dev Biol 299 (2): 563-581.
    • (2006) Dev Biol , vol.299 , Issue.2 , pp. 563-581
    • Kleinjan, D.A.1    Seawright, A.2    Mella, S.3    Carr, C.B.4    Tyas, D.A.5
  • 34
    • 0020537190 scopus 로고
    • Familial aniridia and translocation t(4;11)(q22;p13) without Wilms' tumor
    • Simola KO, Knuutila S, Kaitila I, Pirkola A, Pohja P, (1983) Familial aniridia and translocation t(4;11)(q22;p13) without Wilms' tumor. Hum. Genet 63: 158-161.
    • (1983) Hum. Genet , vol.63 , pp. 158-161
    • Simola, K.O.1    Knuutila, S.2    Kaitila, I.3    Pirkola, A.4    Pohja, P.5
  • 35
    • 0028907724 scopus 로고
    • Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype
    • Fantes J, Redeker B, Breen M, Boyle S, Brown J, et al. (1995) Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype. Hum Mol Genet 4: 415-422.
    • (1995) Hum Mol Genet , vol.4 , pp. 415-422
    • Fantes, J.1    Redeker, B.2    Breen, M.3    Boyle, S.4    Brown, J.5
  • 37
    • 40149100360 scopus 로고    scopus 로고
    • Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence
    • Kleinjan DA, Bancewicz RM, Gautier P, Dahm R, Schonthaler HB, et al. (2008) PLoS Genet 4 (2): e29 Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence.
    • (2008) PLoS Genet , vol.4 , Issue.2
    • Kleinjan, D.A.1    Bancewicz, R.M.2    Gautier, P.3    Dahm, R.4    Schonthaler, H.B.5
  • 38
    • 3042740671 scopus 로고    scopus 로고
    • Comparative genomics at the vertebrate extremes
    • Boffelli D, Nobrega MA, Rubin EM, (2004) Comparative genomics at the vertebrate extremes. Nat Rev Genet 5 (6): 456-65.
    • (2004) Nat Rev Genet , vol.5 , Issue.6 , pp. 456-465
    • Boffelli, D.1    Nobrega, M.A.2    Rubin, E.M.3
  • 39
    • 39049147650 scopus 로고    scopus 로고
    • Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b
    • McGaughey DM, Vinton RM, Huynh J, Al-Saif A, Beer MA, et al. (2008) Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome Res 18 (2): 252-260.
    • (2008) Genome Res , vol.18 , Issue.2 , pp. 252-260
    • McGaughey, D.M.1    Vinton, R.M.2    Huynh, J.3    Al-Saif, A.4    Beer, M.A.5
  • 40
    • 0023899769 scopus 로고
    • Nuclease hypersensitive sites in chromatin
    • Gross DS, Garrard WT, (1988) Nuclease hypersensitive sites in chromatin. Annu.Rev.Biochem 57: 159-197.
    • (1988) Annu.Rev.Biochem , vol.57 , pp. 159-197
    • Gross, D.S.1    Garrard, W.T.2
  • 41
    • 0024263822 scopus 로고
    • The formation and function of DNase I hypersensitive sites in the process of gene activation
    • Elgin SC, (1988) The formation and function of DNase I hypersensitive sites in the process of gene activation. J Biol Chem 263 (36): 19259-19262.
    • (1988) J Biol Chem , vol.263 , Issue.36 , pp. 19259-19262
    • Elgin, S.C.1
  • 42
    • 0034020416 scopus 로고    scopus 로고
    • PipMaker--a web server for aligning two genomic DNA sequences
    • Schwartz S, Zhang Z, Frazer KA, Smit A, Riemer C, et al. (2000) PipMaker--a web server for aligning two genomic DNA sequences. Genome Res 10: 577-586.
    • (2000) Genome Res , vol.10 , pp. 577-586
    • Schwartz, S.1    Zhang, Z.2    Frazer, K.A.3    Smit, A.4    Riemer, C.5
  • 43
    • 33645949095 scopus 로고    scopus 로고
    • Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb
    • Kim J, Lauderdale JD, (2006) Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol 292 (2): 486-505.
    • (2006) Dev Biol , vol.292 , Issue.2 , pp. 486-505
    • Kim, J.1    Lauderdale, J.D.2
  • 44
    • 0028004289 scopus 로고
    • Mice lacking vimentin develop and reproduce without an obvious phenotype
    • Colucci-Guyon E, Portier MM, Dunia I, Paulin D, Pournin S, et al. (1994) Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell 79: 679-694.
    • (1994) Cell , vol.79 , pp. 679-694
    • Colucci-Guyon, E.1    Portier, M.M.2    Dunia, I.3    Paulin, D.4    Pournin, S.5
  • 46
    • 0014558357 scopus 로고
    • Electron microscope observations on virus particles associated with a transplantable renal adenocarcinoma in BALB-cf-Cd mice
    • Felluga B, Claude A, Mrena E, (1969) Electron microscope observations on virus particles associated with a transplantable renal adenocarcinoma in BALB-cf-Cd mice. J Natl. Cancer Inst 43: 319-333.
    • (1969) J Natl. Cancer Inst , vol.43 , pp. 319-333
    • Felluga, B.1    Claude, A.2    Mrena, E.3
  • 47
    • 25844530287 scopus 로고    scopus 로고
    • Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements
    • Pauler FM, Stricker SH, Warczok KE, Barlow DP, (2005) Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements. Genome Res 15 (10): 1379-1387.
    • (2005) Genome Res , vol.15 , Issue.10 , pp. 1379-1387
    • Pauler, F.M.1    Stricker, S.H.2    Warczok, K.E.3    Barlow, D.P.4
  • 48
    • 23844519339 scopus 로고    scopus 로고
    • A high-resolution map of active promoters in the human genome
    • Kim TH, Barrera LO, Zheng M, Qu C, Singer MA, et al. (2005) A high-resolution map of active promoters in the human genome. Nature 436 (7052): 876-880.
    • (2005) Nature , vol.436 , Issue.7052 , pp. 876-880
    • Kim, T.H.1    Barrera, L.O.2    Zheng, M.3    Qu, C.4    Singer, M.A.5
  • 49
    • 0003799113 scopus 로고    scopus 로고
    • Development of the cerebellar system; in relation to its evolution, structure and functions
    • Boca Raton, Florida, CRC press
    • Altman J, Bayer SA, (1997) Development of the cerebellar system; in relation to its evolution, structure and functions. Boca Raton, Florida CRC press.
    • (1997)
    • Altman, J.1    Bayer, S.A.2
  • 50
    • 79959847848 scopus 로고    scopus 로고
    • A novel approach to selectively target neuronal subpopulations reveals genetic pathways that regulate tangential migration in the vertebrate hindbrain
    • Benzing K, Flunkert S, Schedl A, Engelkamp D, (2011) A novel approach to selectively target neuronal subpopulations reveals genetic pathways that regulate tangential migration in the vertebrate hindbrain. PLoS Genet 7 (6): e1002099.
    • (2011) PLoS Genet , vol.7 , Issue.6
    • Benzing, K.1    Flunkert, S.2    Schedl, A.3    Engelkamp, D.4
  • 51
  • 52
    • 29144505399 scopus 로고    scopus 로고
    • Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6
    • Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, et al. (2005) Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron 48 (6): 933-947.
    • (2005) Neuron , vol.48 , Issue.6 , pp. 933-947
    • Landsberg, R.L.1    Awatramani, R.B.2    Hunter, N.L.3    Farago, A.F.4    DiPietrantonio, H.J.5
  • 53
    • 33646823332 scopus 로고    scopus 로고
    • Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse
    • Tyas DA, Simpson TI, Carr CB, Kleinjan DA, van Heyningen V, et al. (2006) Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse. BMC Dev Biol 6: 21.
    • (2006) BMC Dev Biol , vol.6 , pp. 21
    • Tyas, D.A.1    Simpson, T.I.2    Carr, C.B.3    Kleinjan, D.A.4    van Heyningen, V.5
  • 54
    • 58549119985 scopus 로고    scopus 로고
    • The evolution of hierarchical gene regulatory networks
    • Erwin DH, Davidson EH, (2009) The evolution of hierarchical gene regulatory networks. Nat Rev Genet 10 (2): 141-148.
    • (2009) Nat Rev Genet , vol.10 , Issue.2 , pp. 141-148
    • Erwin, D.H.1    Davidson, E.H.2
  • 56
    • 79951741577 scopus 로고    scopus 로고
    • Maintaining a memory by transcriptional autoregulation
    • Hobert O, (2011) Maintaining a memory by transcriptional autoregulation. Curr Biol 21 (4): R146-147.
    • (2011) Curr Biol , vol.21 , Issue.4
    • Hobert, O.1
  • 57
    • 78149408021 scopus 로고    scopus 로고
    • Massive turnover of functional sequence in human and other mammalian genomes
    • Meader S, Ponting CP, Lunter G, (2010) Massive turnover of functional sequence in human and other mammalian genomes. Genome Res 20 (10): 1335-43.
    • (2010) Genome Res , vol.20 , Issue.10 , pp. 1335-1343
    • Meader, S.1    Ponting, C.P.2    Lunter, G.3
  • 58
    • 70350724400 scopus 로고    scopus 로고
    • A novel heterozygous deletion within the 3′ region of the PAX6 gene causing isolated aniridia in a large family group
    • Bayrakli F, Guney I, Bayri Y, Ercan-Sencicek AG, Ceyhan D, et al. (2009) A novel heterozygous deletion within the 3′ region of the PAX6 gene causing isolated aniridia in a large family group. J Clin.Neurosci 16 (12): 1610-1614.
    • (2009) J Clin.Neurosci , vol.16 , Issue.12 , pp. 1610-1614
    • Bayrakli, F.1    Guney, I.2    Bayri, Y.3    Ercan-Sencicek, A.G.4    Ceyhan, D.5
  • 59
    • 77956521381 scopus 로고    scopus 로고
    • Shadow enhancers foster robustness of Drosophila gastrulation
    • Perry MW, Boettiger AN, Bothma JP, Levine M, (2010) Shadow enhancers foster robustness of Drosophila gastrulation. Curr Biol 20 (17): 1562-1567.
    • (2010) Curr Biol , vol.20 , Issue.17 , pp. 1562-1567
    • Perry, M.W.1    Boettiger, A.N.2    Bothma, J.P.3    Levine, M.4
  • 60
    • 77954960062 scopus 로고    scopus 로고
    • Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    • Frankel N, Davis GK, Vargas D, Wang S, Payre F, et al. (2010) Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature 466 (7305): 490-493.
    • (2010) Nature , vol.466 , Issue.7305 , pp. 490-493
    • Frankel, N.1    Davis, G.K.2    Vargas, D.3    Wang, S.4    Payre, F.5
  • 61
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, et al. (2010) Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A 107 (50): 21931-21936.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21931-21936
    • Creyghton, M.P.1    Cheng, A.W.2    Welstead, G.G.3    Kooistra, T.4    Carey, B.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.