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Volumn 100 A, Issue 8, 2012, Pages 2119-2127

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

Author keywords

alveolar epithelial cell; cell contractility; epithelial to mesenchymal transition; fibronectin mutant; substrate stiffness

Indexed keywords

ADHESIVE DOMAINS; ALVEOLAR EPITHELIAL CELLS; CELL INTERACTION; CELL-BINDING DOMAIN; CELLULAR PROCESS; EPITHELIAL CELLS; EPITHELIAL TO MESENCHYMAL TRANSITIONS; EXTRACELLULAR MATRICES; FIBRONECTIN MUTANT; INTEGRINS; LUNG EPITHELIAL CELLS; MECHANICAL CUES; MICROENVIRONMENTS; REGENERATIVE MEDICINE; TISSUE REGENERATION; TRANSFORMING GROWTH FACTOR BETA; VARYING STIFFNESS; WOUND HEALING;

EID: 84862752809     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34068     Document Type: Article
Times cited : (56)

References (40)
  • 1
    • 65649146880 scopus 로고    scopus 로고
    • Integrin signalling at a glance
    • Harburger DS, Calderwood DA,. Integrin signalling at a glance. J Cell Sci 2009; 122 (Part 2): 159-163.
    • (2009) J Cell Sci , vol.122 , Issue.PART 2 , pp. 159-163
    • Harburger, D.S.1    Calderwood, D.A.2
  • 2
    • 4544264684 scopus 로고    scopus 로고
    • Myotubes differentiate optimally on substrates with tissue-like stiffness: Pathological implications for soft or stiff microenvironments
    • Engler AJ, Griffin MA, Sen S, Bonnemann CG, Sweeney HL, Discher DE,. Myotubes differentiate optimally on substrates with tissue-like stiffness: Pathological implications for soft or stiff microenvironments. J Cell Biol 2004; 166: 877-887.
    • (2004) J Cell Biol , vol.166 , pp. 877-887
    • Engler, A.J.1    Griffin, M.A.2    Sen, S.3    Bonnemann, C.G.4    Sweeney, H.L.5    Discher, D.E.6
  • 3
    • 15444368220 scopus 로고    scopus 로고
    • Cell type-specific response to growth on soft materials
    • Georges PC, Janmey PA,. Cell type-specific response to growth on soft materials. J Appl Physiol 2005; 98: 1547-1553.
    • (2005) J Appl Physiol , vol.98 , pp. 1547-1553
    • Georges, P.C.1    Janmey, P.A.2
  • 4
    • 70349496205 scopus 로고    scopus 로고
    • Clustering of α(5)β(1) integrins determines adhesion strength whereas α(v)β(3) and talin enable mechanotransduction
    • Roca-Cusachs P, Gauthier NC, Del Rio A, Sheetz MP,. Clustering of α(5)β(1) integrins determines adhesion strength whereas α(v)β(3) and talin enable mechanotransduction. Proc Natl Acad Sci USA 2009; 106: 16245-16250.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16245-16250
    • Roca-Cusachs, P.1    Gauthier, N.C.2    Del Rio, A.3    Sheetz, M.P.4
  • 6
    • 66749083793 scopus 로고    scopus 로고
    • Integrin switching modulates adhesion dynamics and cell migration
    • Truong H, Danen EH,. Integrin switching modulates adhesion dynamics and cell migration. Cell Adh Migr 2009; 3: 179-181.
    • (2009) Cell Adh Migr , vol.3 , pp. 179-181
    • Truong, H.1    Danen, E.H.2
  • 7
    • 70349773945 scopus 로고    scopus 로고
    • Emerging concepts in engineering extracellular matrix variants for directing cell phenotype
    • Carson AE, Barker TH,. Emerging concepts in engineering extracellular matrix variants for directing cell phenotype. Regen Med 2009; 4: 593-600.
    • (2009) Regen Med , vol.4 , pp. 593-600
    • Carson, A.E.1    Barker, T.H.2
  • 8
    • 0030461127 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition during trophoblast differentiation
    • Vicovac L, Aplin JD,. Epithelial-mesenchymal transition during trophoblast differentiation. Acta Anat (Basel) 1996; 156: 202-216.
    • (1996) Acta Anat (Basel) , vol.156 , pp. 202-216
    • Vicovac, L.1    Aplin, J.D.2
  • 9
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • Hay ED,. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 1995; 154: 8-20.
    • (1995) Acta Anat (Basel) , vol.154 , pp. 8-20
    • Hay, E.D.1
  • 11
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K, et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005; 166: 1321-1332.
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3
  • 13
    • 77954863900 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α
    • Camara J, Jarai G,. Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α. Fibrogenesis Tissue Repair 2010; 3: 2.
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 2
    • Camara, J.1    Jarai, G.2
  • 14
  • 15
    • 60849098434 scopus 로고    scopus 로고
    • Integrin α3β1-dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts
    • Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA,. Integrin α3β1-dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol 2009; 184: 309-322.
    • (2009) J Cell Biol , vol.184 , pp. 309-322
    • Kim, Y.1    Kugler, M.C.2    Wei, Y.3    Kim, K.K.4    Li, X.5    Brumwell, A.N.6    Chapman, H.A.7
  • 16
    • 78650912034 scopus 로고    scopus 로고
    • Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments
    • Brown AC, Rowe JA, Barker TH,. Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments. Tissue Eng Part A 2011; 17: 139-150.
    • (2011) Tissue Eng Part A , vol.17 , pp. 139-150
    • Brown, A.C.1    Rowe, J.A.2    Barker, T.H.3
  • 17
    • 28844459379 scopus 로고    scopus 로고
    • Fibronectin fibrillogenesis, a cell-mediated matrix assembly process
    • Mao Y, Schwarzbauer JE,. Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol 2005; 24: 389-399.
    • (2005) Matrix Biol , vol.24 , pp. 389-399
    • Mao, Y.1    Schwarzbauer, J.E.2
  • 18
    • 0028346713 scopus 로고
    • The role of the ninth and tenth type III domains of human fibronectin in cell adhesion
    • Mardon HJ, Grant KE,. The role of the ninth and tenth type III domains of human fibronectin in cell adhesion. FEBS Lett 1994; 340: 197-201.
    • (1994) FEBS Lett , vol.340 , pp. 197-201
    • Mardon, H.J.1    Grant, K.E.2
  • 19
    • 0036171809 scopus 로고    scopus 로고
    • A structural model for force regulated integrin binding to fibronectin's RGD-synergy site
    • Krammer A, Craig D, Thomas WE, Schulten K, Vogel V,. A structural model for force regulated integrin binding to fibronectin's RGD-synergy site. Matrix Biol 2002; 21: 139-147.
    • (2002) Matrix Biol , vol.21 , pp. 139-147
    • Krammer, A.1    Craig, D.2    Thomas, W.E.3    Schulten, K.4    Vogel, V.5
  • 20
    • 0037107551 scopus 로고    scopus 로고
    • Fibronectin at a glance
    • Pankov R, Yamada KM,. Fibronectin at a glance. J Cell Sci 2002; 115: 3861-3863.
    • (2002) J Cell Sci , vol.115 , pp. 3861-3863
    • Pankov, R.1    Yamada, K.M.2
  • 22
    • 0037117522 scopus 로고    scopus 로고
    • Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension
    • Baneyx G, Baugh L, Vogel V,. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Proc Natl Acad Sci USA 2002; 99: 5139-5143.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5139-5143
    • Baneyx, G.1    Baugh, L.2    Vogel, V.3
  • 23
    • 11244284850 scopus 로고    scopus 로고
    • Interdomain tilt angle determines integrin-dependent function of the ninth and tenth FIII domains of human fibronectin
    • Altroff H, Schlinkert R, van der Walle CF, Bernini A, Campbell ID, Werner JM, Mardon HJ,. Interdomain tilt angle determines integrin-dependent function of the ninth and tenth FIII domains of human fibronectin. J Biol Chem 2004; 279: 55995-56003.
    • (2004) J Biol Chem , vol.279 , pp. 55995-56003
    • Altroff, H.1    Schlinkert, R.2    Van Der Walle, C.F.3    Bernini, A.4    Campbell, I.D.5    Werner, J.M.6    Mardon, H.J.7
  • 24
    • 57749206799 scopus 로고    scopus 로고
    • Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability
    • Martino MM, Mochizuki M, Rothenfluh DA, Rempel SA, Hubbell JA, Barker TH,. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials 2009; 30: 1089-1097.
    • (2009) Biomaterials , vol.30 , pp. 1089-1097
    • Martino, M.M.1    Mochizuki, M.2    Rothenfluh, D.A.3    Rempel, S.A.4    Hubbell, J.A.5    Barker, T.H.6
  • 25
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL, Discher DE,. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126: 677-689.
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 27
    • 33645773666 scopus 로고    scopus 로고
    • Local force and geometry sensing regulate cell functions
    • Vogel V, Sheetz M,. Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol 2006; 7: 265-275.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 265-275
    • Vogel, V.1    Sheetz, M.2
  • 28
    • 79952598024 scopus 로고    scopus 로고
    • Integrins and extracellular matrix in mechanotransduction
    • Schwartz MA,. Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2010; 2: a005066.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Schwartz, M.A.1
  • 29
    • 38649102530 scopus 로고    scopus 로고
    • The role of extracellular matrix, integrins, and cytoskeleton in mechanotransduction of centrifugal loading
    • Li J, Zhao Z, Wang J, Chen G, Yang J, Luo S,. The role of extracellular matrix, integrins, and cytoskeleton in mechanotransduction of centrifugal loading. Mol Cell Biochem 2008; 309: 41-48.
    • (2008) Mol Cell Biochem , vol.309 , pp. 41-48
    • Li, J.1    Zhao, Z.2    Wang, J.3    Chen, G.4    Yang, J.5    Luo, S.6
  • 30
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
    • Wipff PJ, Rifkin DB, Meister JJ, Hinz B,. Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix. J Cell Biol 2007; 179: 1311-1323.
    • (2007) J Cell Biol , vol.179 , pp. 1311-1323
    • Wipff, P.J.1    Rifkin, D.B.2    Meister, J.J.3    Hinz, B.4
  • 31
    • 0242509224 scopus 로고    scopus 로고
    • ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix
    • Wozniak MA, Desai R, Solski PA, Der CJ, Keely PJ,. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol 2003; 163: 583-595.
    • (2003) J Cell Biol , vol.163 , pp. 583-595
    • Wozniak, M.A.1    Desai, R.2    Solski, P.A.3    Der, C.J.4    Keely, P.J.5
  • 32
    • 6344254484 scopus 로고    scopus 로고
    • TGF-β1 induces alveolar epithelial to mesenchymal transition in vitro
    • Yao HW, Xie QM, Chen JQ, Deng YM, Tang HF,. TGF-β1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci 2004; 76: 29-37.
    • (2004) Life Sci , vol.76 , pp. 29-37
    • Yao, H.W.1    Xie, Q.M.2    Chen, J.Q.3    Deng, Y.M.4    Tang, H.F.5
  • 33
    • 34347228684 scopus 로고    scopus 로고
    • Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-β1
    • Jain R, Shaul PW, Borok Z, Willis BC,. Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-β1. Am J Respir Cell Mol Biol 2007; 37: 38-47.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 38-47
    • Jain, R.1    Shaul, P.W.2    Borok, Z.3    Willis, B.C.4
  • 34
    • 26244458018 scopus 로고    scopus 로고
    • TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z,. TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005; 6: 56.
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 35
    • 9644274187 scopus 로고    scopus 로고
    • Integrity of cell-cell contacts is a critical regulator of TGF-β 1-induced epithelial-to-myofibroblast transition: Role for β-catenin
    • Masszi A, Fan L, Rosivall L, McCulloch CA, Rotstein OD, Mucsi I, Kapus A,. Integrity of cell-cell contacts is a critical regulator of TGF-β 1-induced epithelial-to-myofibroblast transition: Role for β-catenin. Am J Pathol 2004; 165: 1955-1967.
    • (2004) Am J Pathol , vol.165 , pp. 1955-1967
    • Masszi, A.1    Fan, L.2    Rosivall, L.3    McCulloch, C.A.4    Rotstein, O.D.5    Mucsi, I.6    Kapus, A.7
  • 36
    • 59449090107 scopus 로고    scopus 로고
    • TGF-β-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R,. TGF-β-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 37
    • 65549160523 scopus 로고    scopus 로고
    • Tissue stiffness, latent TGF-β1 activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis
    • Hinz B,. Tissue stiffness, latent TGF-β1 activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep 2009; 11: 120-126.
    • (2009) Curr Rheumatol Rep , vol.11 , pp. 120-126
    • Hinz, B.1
  • 38
    • 77953816876 scopus 로고    scopus 로고
    • Preparation of hydrogel substrates with tunable mechanical properties
    • Tse JR, Engler AJ,. Preparation of hydrogel substrates with tunable mechanical properties. Curr Protoc Cell Biol 2010; 47: 10.16.1-10.16.16.
    • (2010) Curr Protoc Cell Biol , vol.47 , pp. 10161-101616
    • Tse, J.R.1    Engler, A.J.2
  • 39
    • 0028328817 scopus 로고
    • An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
    • Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB,. An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 1994; 216: 276-284.
    • (1994) Anal Biochem , vol.216 , pp. 276-284
    • Abe, M.1    Harpel, J.G.2    Metz, C.N.3    Nunes, I.4    Loskutoff, D.J.5    Rifkin, D.B.6


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