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Volumn 4, Issue MAY, 2012, Pages 1-6

Less efficient pattern separation may contribute to age-related spatial memory deficits

Author keywords

Aging; Dentate gyrus; Hippocampus; Interference; Pattern separatio; Spatial memory

Indexed keywords

AGING; ALZHEIMER DISEASE; COGNITIVE DEFECT; DENDRITIC CELL; DENTATE GYRUS; EPISODIC MEMORY; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; MEMORY DISORDER; NERVE DEGENERATION; NONHUMAN; PRIMATE; RISK FACTOR; SCIENCE; SHORT SURVEY; SPATIAL MEMORY; TRANSLATIONAL RESEARCH;

EID: 84862741813     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2012.00009     Document Type: Short Survey
Times cited : (54)

References (80)
  • 1
    • 77954027359 scopus 로고    scopus 로고
    • Adult neurogenesis: integrating theories and separating functions
    • Aimone, J. B., Deng, W., and Gage, F. H. (2010). Adult neurogenesis: integrating theories and separating functions. Trends Cogn. Sci. 14, 325-337.
    • (2010) Trends Cogn. Sci. , vol.14 , pp. 325-337
    • Aimone, J.B.1    Deng, W.2    Gage, F.H.3
  • 2
    • 79956192109 scopus 로고    scopus 로고
    • Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation
    • Aimone, J. B., Deng, W., and Gage, F. H. (2011). Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron 70, 589-596.
    • (2011) Neuron , vol.70 , pp. 589-596
    • Aimone, J.B.1    Deng, W.2    Gage, F.H.3
  • 3
    • 33847750722 scopus 로고    scopus 로고
    • Visual and visu-ospatial short-term memory in mild cognitive impairment and Alzheimer disease: role of attention
    • Alescio-Lautier, B., Michel, B. F., Herrera, C., Elahmadi, A., Chambon, C., Touzet, C., and Paban, V. (2007). Visual and visu-ospatial short-term memory in mild cognitive impairment and Alzheimer disease: role of attention. Neuropsychologia 45, 1948-1960.
    • (2007) Neuropsychologia , vol.45 , pp. 1948-1960
    • Alescio-Lautier, B.1    Michel, B.F.2    Herrera, C.3    Elahmadi, A.4    Chambon, C.5    Touzet, C.6    Paban, V.7
  • 5
    • 84858225391 scopus 로고    scopus 로고
    • Alzheimer's Association report: 2012 Alzheimer's disease facts and figures
    • Alzheimer's Association. Alzheimers Dement
    • Alzheimer's Association. (2012). Alzheimer's Association report: 2012 Alzheimer's disease facts and figures. Alzheimers Dement. 8, 131-168.
    • (2012) , vol.8 , pp. 131-168
  • 7
    • 41149088380 scopus 로고    scopus 로고
    • Pattern separation in the human hippocampal CA3 and dentate gyrus
    • Bakker, A., Kirwan, C. B., Miller, M., and Stark, C. E. (2008). Pattern separation in the human hippocampal CA3 and dentate gyrus. Science 319, 1640-1642.
    • (2008) Science , vol.319 , pp. 1640-1642
    • Bakker, A.1    Kirwan, C.B.2    Miller, M.3    Stark, C.E.4
  • 8
    • 0024162045 scopus 로고
    • Aging and the physiology of spatial memory
    • Barnes, C. A. (1988). Aging and the physiology of spatial memory. Neurobiol. Aging 9, 563-568.
    • (1988) Neurobiol. Aging , vol.9 , pp. 563-568
    • Barnes, C.A.1
  • 9
    • 0033046072 scopus 로고    scopus 로고
    • Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease
    • Bondi, M. W., Salmon, D. P., Galasko, D., Thomas, R. G., and Thal, L. J. (1999).Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychol. Aging 14, 295-303.
    • (1999) Psychol. Aging , vol.14 , pp. 295-303
    • Bondi, M.W.1    Salmon, D.P.2    Galasko, D.3    Thomas, R.G.4    Thal, L.J.5
  • 10
    • 0029967367 scopus 로고    scopus 로고
    • Development of Alzheimer-related neurofibrillary changes in the neo-cortex inversely recapitulates cortical myelogenesis
    • Braak, H., and Braak, E. (1996). Development of Alzheimer-related neurofibrillary changes in the neo-cortex inversely recapitulates cortical myelogenesis. Acta Neuropathol. 92, 197-201.
    • (1996) Acta Neuropathol , vol.92 , pp. 197-201
    • Braak, H.1    Braak, E.2
  • 12
    • 75949090172 scopus 로고    scopus 로고
    • Imaging the human medial temporal lobe with high-resolution fMRI
    • Carr, V. A., Rissman, J., and Wagner, A. D. (2010). Imaging the human medial temporal lobe with high-resolution fMRI. Neuron 65, 298-308.
    • (2010) Neuron , vol.65 , pp. 298-308
    • Carr, V.A.1    Rissman, J.2    Wagner, A.D.3
  • 16
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory
    • Deng, W., Aimone, J. B., and Gage, F. H. (2010). New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat. Rev. Neurosci. 11,339-350.
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 17
    • 67650088150 scopus 로고    scopus 로고
    • Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
    • Driscoll, I., Davatzikos, C., An, Y., Wu, X., Shen, D., Kraut, M., and Resnick, S. M. (2009). Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology 72, 1906-1913.
    • (2009) Neurology , vol.72 , pp. 1906-1913
    • Driscoll, I.1    Davatzikos, C.2    An, Y.3    Wu, X.4    Shen, D.5    Kraut, M.6    Resnick, S.M.7
  • 19
    • 20444369864 scopus 로고    scopus 로고
    • The aging hippocampus: navigating between rat and human experiments
    • Driscoll, I., and Sutherland, R. J. (2005). The aging hippocampus: navigating between rat and human experiments. Rev. Neurosci. 16, 87-121.
    • (2005) Rev. Neurosci. , vol.16 , pp. 87-121
    • Driscoll, I.1    Sutherland, R.J.2
  • 20
    • 0026938047 scopus 로고
    • Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique
    • Geinisman, Y., deToledo-Morrell, L., Morrell, F., Persina, I. S., and Rossi, M. (1992). Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus 2, 437-444.
    • (1992) Hippocampus , vol.2 , pp. 437-444
    • Geinisman, Y.1    deToledo-Morrell, L.2    Morrell, F.3    Persina, I.S.4    Rossi, M.5
  • 21
    • 0035689480 scopus 로고    scopus 로고
    • Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1
    • Gilbert, P. E., Kesner, R. P., and Lee, I. (2001). Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1. Hippocampus 11, 626-636.
    • (2001) Hippocampus , vol.11 , pp. 626-636
    • Gilbert, P.E.1    Kesner, R.P.2    Lee, I.3
  • 22
    • 67649202232 scopus 로고    scopus 로고
    • The role of the CA3 hippocampal subregion in spa tial memory: a process oriented behavioral assessment
    • Gilbert, P. E., and Brushfield, A. M. (2009). The role of the CA3 hippocampal subregion in spa tial memory: a process oriented behavioral assessment. Prog. Neuropsychopharmacol Biol. Psychiatry 33, 774-781.
    • (2009) Prog. Neuropsychopharmacol Biol. Psychiatry , vol.33 , pp. 774-781
    • Gilbert, P.E.1    Brushfield, A.M.2
  • 23
    • 33244456151 scopus 로고    scopus 로고
    • The role of the dorsal CA3 hippocampal subregion in spatial working memory and pattern separation. Behav
    • Gilbert, P. E., and Kesner, R. P. (2006). The role of the dorsal CA3 hippocampal subregion in spatial working memory and pattern separation. Behav. Brain Res. 169, 142-149.
    • (2006) Brain Res , vol.169 , pp. 142-149
    • Gilbert, P.E.1    Kesner, R.P.2
  • 25
    • 40749130747 scopus 로고    scopus 로고
    • The interactions and dissociations of the dorsal hippocampus subre-gions: how the dentate gyrus, CA3, and CA1 process spatial information
    • Goodrich-Hunsaker, N. J., Hunsaker, M. R., and Kesner, R. P. (2008). The interactions and dissociations of the dorsal hippocampus subre-gions: how the dentate gyrus, CA3, and CA1 process spatial information. Behav. Neurosci. 122, 16-26.
    • (2008) Behav. Neurosci , vol.122 , pp. 16-26
    • Goodrich-Hunsaker, N.J.1    Hunsaker, M.R.2    Kesner, R.P.3
  • 26
    • 33646707280 scopus 로고    scopus 로고
    • Evolution of cognitive deficits and conversion to dementia in patients with mild cognitive impairment: a very-long-term follow-up study
    • Hodges, J. R., Erzinclioglu, S., and Patterson, K. (2006). Evolution of cognitive deficits and conversion to dementia in patients with mild cognitive impairment: a very-long-term follow-up study. Dement. Geriatr. Cogn. Disord. 21,380-391.
    • (2006) Dement. Geriatr. Cogn. Disord. , vol.21 , pp. 380-391
    • Hodges, J.R.1    Erzinclioglu, S.2    Patterson, K.3
  • 27
    • 84865577239 scopus 로고    scopus 로고
    • Spatial pattern separation in cognitively normal young and older adults
    • doi: 10.1002/hipo.22017. [Epub ahead of print]
    • Holden, H. M., Hoebel, C., Loftis, K., and Gilbert, P. E. (2012). Spatial pattern separation in cognitively normal young and older adults. Hippocampus. doi: 10.1002/hipo.22017. [Epub ahead of print].
    • (2012) Hippocampus
    • Holden, H.M.1    Hoebel, C.2    Loftis, K.3    Gilbert, P.E.4
  • 30
    • 4444302117 scopus 로고    scopus 로고
    • Molecular genetics of late-onset Alzheimer's disease
    • Kamboh, M. I. (2004). Molecular genetics of late-onset Alzheimer's disease. Ann. Hum. Genet. 68, 381-404.
    • (2004) Ann. Hum. Genet. , vol.68 , pp. 381-404
    • Kamboh, M.I.1
  • 31
    • 59849120110 scopus 로고    scopus 로고
    • Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed
    • Kennedy, K. M., and Raz, N. (2009). Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia 47, 916-927.
    • (2009) Neuropsychologia , vol.47 , pp. 916-927
    • Kennedy, K.M.1    Raz, N.2
  • 32
    • 34548267128 scopus 로고    scopus 로고
    • A behavioral analysis of dentate gyrus function. Prog
    • Kesner, R. P. (2007). A behavioral analysis of dentate gyrus function. Prog. Brain Res. 163,567-576.
    • (2007) Brain Res , vol.163 , pp. 567-576
    • Kesner, R.P.1
  • 33
    • 17644410348 scopus 로고    scopus 로고
    • The contribution of implicit and explicit memory to the effects of errorless learning: a comparison between young and older adults
    • Kessels, R. P., Boekhorst, S. T., and Postma, A. (2005). The contribution of implicit and explicit memory to the effects of errorless learning: a comparison between young and older adults. J. Int. Neuropsychol. Soc. 11, 144-151.
    • (2005) J. Int. Neuropsychol. Soc. , vol.11 , pp. 144-151
    • Kessels, R.P.1    Boekhorst, S.T.2    Postma, A.3
  • 34
    • 34548839628 scopus 로고    scopus 로고
    • Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe
    • Kirwan, C. B., and Stark, C. E. (2007). Overcoming interference: an fMRI investigation of pattern separation in the medial temporal lobe. Learn. Mem. 14, 625-633.
    • (2007) Learn. Mem. , vol.14 , pp. 625-633
    • Kirwan, C.B.1    Stark, C.E.2
  • 36
    • 36448970079 scopus 로고    scopus 로고
    • Using immediate-early genes to map hippocampal subre-gional functions
    • Kubik, S., Miyashita, T., and Guzowski, J. F. (2007). Using immediate-early genes to map hippocampal subre-gional functions. Learn. Mem. 14, 758-770.
    • (2007) Learn. Mem. , vol.14 , pp. 758-770
    • Kubik, S.1    Miyashita, T.2    Guzowski, J.F.3
  • 37
    • 34249017549 scopus 로고    scopus 로고
    • Interference effects by spatial proximity and age-related declines in spatial memory by Japanese monkeys (Macaca fuscata): deficits in the combined use of multiple spatial cues
    • Kubo-Kawai, N., and Kawai, N. (2007). Interference effects by spatial proximity and age-related declines in spatial memory by Japanese monkeys (Macaca fuscata): deficits in the combined use of multiple spatial cues.J. Comp. Psychol. 121,189-197.
    • (2007) J. Comp. Psychol , vol.121 , pp. 189-197
    • Kubo-Kawai, N.1    Kawai, N.2
  • 38
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn, H. G., Dickinson-Anson, H., and Gage, F. H. (1996). Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation.J. Neurosci. 16, 2027-2033.
    • (1996) J. Neurosci , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 39
    • 78650994901 scopus 로고    scopus 로고
    • Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
    • Lacy, J. W., Yassa, M. A., Stark, S. M., Muftuler, L. T., and Stark, C. E. (2011). Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learn. Mem. 18, 15-18.
    • (2011) Learn. Mem. , vol.18 , pp. 15-18
    • Lacy, J.W.1    Yassa, M.A.2    Stark, S.M.3    Muftuler, L.T.4    Stark, C.E.5
  • 40
    • 23744444821 scopus 로고    scopus 로고
    • Disruption of delayed memory for a sequence of spatial locations following CA1- or CA3-lesions of the dorsal hippocampus
    • Lee, I., Jerman, T. S., and Kesner, R. P. (2005). Disruption of delayed memory for a sequence of spatial locations following CA1- or CA3-lesions of the dorsal hippocampus. Neurobiol. Learn. Mem. 84, 138-147.
    • (2005) Neurobiol. Learn. Mem , vol.84 , pp. 138-147
    • Lee, I.1    Jerman, T.S.2    Kesner, R.P.3
  • 41
    • 33847149696 scopus 로고    scopus 로고
    • Pattern separation in the dentate gyrus and CA3 of the hippocampus
    • Leutgeb, J. K., Leutgeb, S., Moser, M. B., and Moser, E. I. (2007). Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 315,961-966.
    • (2007) Science , vol.315 , pp. 961-966
    • Leutgeb, J.K.1    Leutgeb, S.2    Moser, M.B.3    Moser, E.I.4
  • 42
    • 0015083717 scopus 로고
    • Simple memory: a theory for archicortex
    • Marr, D. (1971). Simple memory: a theory for archicortex. Proc. R. Soc. Lond. B Biol. Sci. 262,23-81.
    • (1971) Proc. R. Soc. Lond. B Biol. Sci. , vol.262 , pp. 23-81
    • Marr, D.1
  • 43
    • 84856428603 scopus 로고    scopus 로고
    • Increased pattern separation in the aged fascia dentata
    • Marrone, D. F., Adams, A. A., and Satvat, E. (2011). Increased pattern separation in the aged fascia dentata. Neurobiol Aging 32, 2317.e23-e32.
    • (2011) Neurobiol Aging , vol.32 , Issue.2317
    • Marrone, D.F.1    Adams, A.A.2    Satvat, E.3
  • 45
    • 0024407258 scopus 로고
    • Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge. Exp
    • McNaughton, B. L., Barnes, C. A., Meltzer, J., and Sutherland, R. J. (1989). Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge. Exp. Brain Res. 76, 485-496.
    • (1989) Brain Res , vol.76 , pp. 485-496
    • McNaughton, B.L.1    Barnes, C.A.2    Meltzer, J.3    Sutherland, R.J.4
  • 46
    • 0002345327 scopus 로고
    • Hebb-Marr networks and the neurobiological representation of action in space
    • eds M. A. Gluck and D. E. Rumelhart (Hillsdale, NJ: Erlbaum)
    • McNaughton, B. L., and Nadel, L. (1990). "Hebb-Marr networks and the neurobiological representation of action in space," in Neuroscience and Connectionist Theory, eds M. A. Gluck and D. E. Rumelhart (Hillsdale, NJ: Erlbaum), 1-63.
    • (1990) Neuroscience and Connectionist Theory , pp. 1-63
    • McNaughton, B.L.1    Nadel, L.2
  • 47
    • 67549096690 scopus 로고    scopus 로고
    • A new touchscreen test of pattern separation: effect of hippocampal lesions
    • McTighe, S. M., Mar, A. C., Romberg, C., Bussey, T. J., and Saksida, L. M. (2009). A new touchscreen test of pattern separation: effect of hippocampal lesions. Neuroreport 20, 881-885.
    • (2009) Neuroreport , vol.20 , pp. 881-885
    • McTighe, S.M.1    Mar, A.C.2    Romberg, C.3    Bussey, T.J.4    Saksida, L.M.5
  • 48
    • 84859156223 scopus 로고    scopus 로고
    • Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations
    • Morris, A. M., Churchwell, J. C., Kesner, R. P., and Gilbert, P. E. (2012). Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations. Neurobiol. Learn. Mem. 97,326-331.
    • (2012) Neurobiol. Learn. Mem. , vol.97 , pp. 326-331
    • Morris, A.M.1    Churchwell, J.C.2    Kesner, R.P.3    Gilbert, P.E.4
  • 50
    • 63849246744 scopus 로고    scopus 로고
    • A role for hilar cells in pattern separation in the dentate gyrus: a computational approach
    • Myers, C. E., and Scharfman, H. E. (2009). A role for hilar cells in pattern separation in the dentate gyrus: a computational approach. Hippocampus 19, 321-337.
    • (2009) Hippocampus , vol.19 , pp. 321-337
    • Myers, C.E.1    Scharfman, H.E.2
  • 52
    • 0028585928 scopus 로고
    • Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off
    • O'Reilly, R. C., and McClelland, J. L. (1994). Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off. Hippocampus 4, 661-682.
    • (1994) Hippocampus , vol.4 , pp. 661-682
    • O'Reilly, R.C.1    McClelland, J.L.2
  • 53
    • 34548216270 scopus 로고    scopus 로고
    • The effects of aging on dentate circuitry and function. Prog
    • Patrylo, P. R., and Williamson, A. (2007). The effects of aging on dentate circuitry and function. Prog. Brain Res. 163,679-696.
    • (2007) Brain Res , vol.163 , pp. 679-696
    • Patrylo, P.R.1    Williamson, A.2
  • 55
    • 0034849725 scopus 로고    scopus 로고
    • Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
    • Price, J. L., Ko, A. I., Wade, M. J., Tsou, S.K., McKeel, D. W., and Morris, J. C. (2001). Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch. Neurol. 58, 1395-1402.
    • (2001) Arch. Neurol. , vol.58 , pp. 1395-1402
    • Price, J.L.1    Ko, A.I.2    Wade, M.J.3    Tsou, S.K.4    McKeel, D.W.5    Morris, J.C.6
  • 57
    • 1042305449 scopus 로고    scopus 로고
    • Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume
    • Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K. M., Williamson, A., and Acker, J. D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiol. Aging 25, 377-396.
    • (2004) Neurobiol. Aging , vol.25 , pp. 377-396
    • Raz, N.1    Gunning-Dixon, F.2    Head, D.3    Rodrigue, K.M.4    Williamson, A.5    Acker, J.D.6
  • 59
    • 77954814641 scopus 로고    scopus 로고
    • A computational theory of episodic memory formation in the hippocampus. Behav
    • Rolls, E. T. (2010). A computational theory of episodic memory formation in the hippocampus. Behav. Brain Res. 215, 180-196.
    • (2010) Brain Res , vol.215 , pp. 180-196
    • Rolls, E.T.1
  • 60
    • 33745743474 scopus 로고    scopus 로고
    • A computational theory of hippocampal function, and empirical tests of the theory
    • Rolls, E. T., and Kesner, R. P. (2006). A computational theory of hippocampal function, and empirical tests of the theory. Prog. Neurobiol. 79, 1-48.
    • (2006) Prog. Neurobiol. , vol.79 , pp. 1-48
    • Rolls, E.T.1    Kesner, R.P.2
  • 61
    • 0023904094 scopus 로고
    • A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease
    • Sahakian, B. J., Morris, R. G., Evenden, J. L., Heald, A., Levy, R., Philpot, M., and Robbins, T. W. (1988). A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111,695-718.
    • (1988) Brain , vol.111 , pp. 695-718
    • Sahakian, B.J.1    Morris, R.G.2    Evenden, J.L.3    Heald, A.4    Levy, R.5    Philpot, M.6    Robbins, T.W.7
  • 62
    • 79956221127 scopus 로고    scopus 로고
    • Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
    • Sahay, A., Wilson, D. A., and Hen, R. (2011). Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron 70, 582-588.
    • (2011) Neuron , vol.70 , pp. 582-588
    • Sahay, A.1    Wilson, D.A.2    Hen, R.3
  • 64
    • 0002450271 scopus 로고
    • Hippocampal Function and Interference
    • eds D. L. Schacter and E. Tulving (London: MIT)
    • Shapiro, M. L., and Olton, D. S. (1994). "Hippocampal Function and Interference," in Memory Systems, eds D. L. Schacter and E. Tulving (London: MIT), 141-146.
    • (1994) Memory Systems , pp. 141-146
    • Shapiro, M.L.1    Olton, D.S.2
  • 65
    • 77957885945 scopus 로고    scopus 로고
    • Assessment of spatial memory in mice
    • Sharma, S., Rakoczy, S., and Brown-Borg, H. (2010). Assessment of spatial memory in mice. Life Sci. 87, 521-536.
    • (2010) Life Sci , vol.87 , pp. 521-536
    • Sharma, S.1    Rakoczy, S.2    Brown-Borg, H.3
  • 67
    • 2342557824 scopus 로고    scopus 로고
    • Small, S. A., Chawla, M. K., Buonocore, M., Rapp, P. R., and Barnes, C. A. (2004). Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proc. Natl. Acad. Sci. U.S.A. 101, 7181-7186.
    • (2004) , vol.101 , pp. 7181-7186
    • Small, S.1    Chawla, M.K.2    Buonocore, M.3    Rapp, P.R.4    Barnes, C.A.5
  • 68
    • 0036194064 scopus 로고    scopus 로고
    • Imaging hippocampal function across the human life span: is memory decline normal or not
    • Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., and Stern, Y. (2002). Imaging hippocampal function across the human life span: is memory decline normal or not? Ann. Neurol. 51,290-295.
    • (2002) Ann. Neurol. , vol.51 , pp. 290-295
    • Small, S.A.1    Tsai, W.Y.2    DeLaPaz, R.3    Mayeux, R.4    Stern, Y.5
  • 69
    • 0034279244 scopus 로고    scopus 로고
    • Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats
    • Smith, T. D., Adams, M. M., Gallagher, M., Morrison, J. H., and Rapp, P. R. (2000). Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J. Neurosci. 20, 6587-6593.
    • (2000) J. Neurosci. , vol.20 , pp. 6587-6593
    • Smith, T.D.1    Adams, M.M.2    Gallagher, M.3    Morrison, J.H.4    Rapp, P.R.5
  • 70
    • 77953054528 scopus 로고    scopus 로고
    • Individual differences in spatial pattern separation performance associated with healthy aging in humans
    • Stark, S. M., Yassa, M. A., and Stark, C. E. (2010). Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learn. Mem. 17, 284-288.
    • (2010) Learn. Mem. , vol.17 , pp. 284-288
    • Stark, S.M.1    Yassa, M.A.2    Stark, C.E.3
  • 71
    • 0033008177 scopus 로고    scopus 로고
    • Hippocampal place cells can develop distinct representations of two visually identical environments
    • Tanila, H. (1999). Hippocampal place cells can develop distinct representations of two visually identical environments. Hippocampus 9, 235-246.
    • (1999) Hippocampus , vol.9 , pp. 235-246
    • Tanila, H.1
  • 72
    • 66149091970 scopus 로고    scopus 로고
    • Visual object pattern separation deficits in nondemented older adults
    • Toner, C. K., Pirogovsky, E., Kirwan, C. B., and Gilbert, P. E. (2009). Visual object pattern separation deficits in nondemented older adults. Learn. Mem. 16, 338-342.
    • (2009) Learn. Mem. , vol.16 , pp. 338-342
    • Toner, C.K.1    Pirogovsky, E.2    Kirwan, C.B.3    Gilbert, P.E.4
  • 73
    • 77952879134 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuorimaging Initiative Multi-modal imaging predicts memory performances in normal aging and cognitive decline
    • Walhovd, K. B., Fjell, A. M., Dale, A. M., McEvoy, L. K., Brewer, J., Karow, D. S., Salmon, D. P., and Fennema-Notestine, C., (2010). Alzheimer's Disease Neuorimaging Initiative. Multi-modal imaging predicts memory performances in normal aging and cognitive decline. Neurobiol. Aging 31, 1107-1112.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1107-1112
    • Walhovd, K.B.1    Fjell, A.M.2    Dale, A.M.3    McEvoy, L.K.4    Brewer, J.5    Karow, D.S.6    Salmon, D.P.7    Fennema-Notestine, C.8
  • 74
    • 0033930916 scopus 로고    scopus 로고
    • The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease
    • West, M. J., Kawas, C. H., Martin, L. J., and Troncoso, J. C. (2000). The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Ann. N.Y. Acad. Sci. 908, 255-259.
    • (2000) Ann. N. Y. Acad. Sci. , vol.908 , pp. 255-259
    • West, M.J.1    Kawas, C.H.2    Martin, L.J.3    Troncoso, J.C.4
  • 75
    • 33751178775 scopus 로고    scopus 로고
    • Neurocognitive aging: prior memories hinder new hippocampal encoding
    • Wilson, I. A., Gallagher, M., Eichenbaum, H., and Tanila, H. (2006). Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 29, 662-670.
    • (2006) Trends Neurosci , vol.29 , pp. 662-670
    • Wilson, I.A.1    Gallagher, M.2    Eichenbaum, H.3    Tanila, H.4
  • 76
    • 80051937468 scopus 로고    scopus 로고
    • Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
    • Yassa, M. A., Lacy, J. W., Stark, S. M., Albert, M. S., Gallagher, M., and Stark, C. E. (2010). Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21,968-979.
    • (2010) Hippocampus , vol.21 , pp. 968-979
    • Yassa, M.A.1    Lacy, J.W.2    Stark, S.M.3    Albert, M.S.4    Gallagher, M.5    Stark, C.E.6
  • 77
    • 79957738688 scopus 로고    scopus 로고
    • Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
    • Yassa, M. A., Mattfeld, A. T., Stark, S. M., and Stark, C. E. (2011). Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc. Natl Acad. Sci. U.S.A. 108, 8873-8878.
    • (2011) Proc. Natl Acad. Sci. U. S. A. , vol.108 , pp. 8873-8878
    • Yassa, M.A.1    Mattfeld, A.T.2    Stark, S.M.3    Stark, C.E.4
  • 78
    • 77952422876 scopus 로고    scopus 로고
    • High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment
    • Yassa, M. A., Stark, S. M., Bakker, A., Albert, M. S., Gallagher, M., and Stark, C. E. (2010). High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage 51, 1242-1252.
    • (2010) Neuroimage , vol.51 , pp. 1242-1252
    • Yassa, M.A.1    Stark, S.M.2    Bakker, A.3    Albert, M.S.4    Gallagher, M.5    Stark, C.E.6
  • 79
    • 80053125086 scopus 로고    scopus 로고
    • Pattern separation in the hippocampus
    • Yassa, M. A., and Stark, C. E. (2011). Pattern separation in the hippocampus. Trends. Neurosci. 34, 515-525.
    • (2011) Trends. Neurosci. , vol.34 , pp. 515-525
    • Yassa, M.A.1    Stark, C.E.2
  • 80
    • 77956945637 scopus 로고    scopus 로고
    • Cognition in healthy aging is related to regional white matter integrity, but not cortical thickness
    • Ziegler, D. A., Piguet, O., Salat, D. H., Prince, K., Connally, E., and Corkin, S. (2008). Cognition in healthy aging is related to regional white matter integrity, but not cortical thickness. Neurobiol Aging 31, 1912-1926.
    • (2008) Neurobiol Aging , vol.31 , pp. 1912-1926
    • Ziegler, D.A.1    Piguet, O.2    Salat, D.H.3    Prince, K.4    Connally, E.5    Corkin, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.