Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system

Endocrinology

Volumn 153, Issue 7, 2012, Pages 3368-3375

  Smith, Jeremy T ^a   Young, I Ross ^a   Veldhuis, Johannes D ^b   Clarke, Iain J ^a  

^a MONASH UNIVERSITY   (Australia)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; GONADOTROPIN; GONADOTROPIN INHIBITORY HORMONE 3; LUTEINIZING HORMONE; MESSENGER RNA; NEUROHORMONE; UNCLASSIFIED DRUG;

ANESTRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; BREEDING; CELL TYPE; CONTROLLED STUDY; ESTRUS CYCLE; FOLLICULAR PHASE; HORMONE RELEASE; HYPOPHYSIS CELL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; JUGULAR VEIN; LUTEAL PHASE; NONHUMAN; PORTAL VEIN; PORTAL VEIN BLOOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMUS DORSOMEDIAL NUCLEUS;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HORMONES; LUTEINIZING HORMONE; MEDIODORSAL THALAMIC NUCLEUS; PITUITARY GLAND; RADIOIMMUNOASSAY; RECEPTORS, NEUROPEPTIDE; SHEEP; TISSUE DISTRIBUTION;

EID: 84862727773     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1088     Document Type: Article

References (43)

1. Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, Kikuchi M, Ishii S, Sharp PJ 2000Anovel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275:661-667
2. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE 2008 Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 149:5811-5821
3. Kriegsfeld LJ, Mei DF, Bentley GE, Ubuka T, Mason AO, Inoue K, Ukena K, Tsutsui K, Silver R 2006 Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc Natl Acad Sci USA 103:2410-2415 (Pubitemid 43271683)
4. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M 2000 New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2:703-708
5. Ukena K, Tsutsui K 2001 Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system. Neurosci Lett 300:153-156 (Pubitemid 32168210)
6. Smith JT, Clarke IJ 2010 Gonadotropin inhibitory hormone function in mammals. Trends Endocrinol Metab 21:255-260
7. Tsutsui K, Bentley GE, Bedecarrats G, Osugi T, Ubuka T, Kriegsfeld LJ 2010 Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function. Front Neuroendocrinol 31:284-295
8. Khan AR, Kauffman AS 2012 The role of kisspeptin and RFamiderelated peptide-3 neurones in the circadian-timed preovulatory luteinising hormone surge. J Neuroendocrinol 24:131-143
9. Ubuka T, Inoue K, Fukuda Y, Mizuno T, Ukena K, Kriegsfeld LJ, Tsutsui K 2012 Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone. Endocrinology 153:373-385
10. Johnson MA, Tsutsui K, Fraley GS 2007 Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav 51:171-180 (Pubitemid 44838645)
11. Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-SempereM2010 Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies. Am J Physiol Endocrinol Metab 299:E39-E46
12. Anderson GM, Relf HL, Rizwan MZ, Evans JJ 2009 Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology 150:1834-1840
13. Qi Y, Oldfield BJ, Clarke IJ 2009 Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. J Neuroendocrinol 21:690-697
14. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN 2008 Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 149:5770-5782
15. Smith JT, Shahab M, Pereira A, Pau KY, Clarke IJ 2010 Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol Reprod 83:568-577
16. Ubuka T, Lai H, Kitani M, Suzuuchi A, Pham V, Cadigan PA, Wang A, Chowdhury VS, Tsutsui K, Bentley GE 2009 Gonadotropininhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain. J Comp Neurol 517:841-855
17. Ubuka T, Morgan K, Pawson AJ, Osugi T, Chowdhury VS, Minakata H, Tsutsui K, Millar RP, Bentley GE 2009 Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4:e8400
18. Ducret E, Anderson GM, Herbison AE 2009 RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology 150:2799-2804
19. Wu M, Dumalska I, Morozova E, van den Pol AN, Alreja M 2009 Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism. J Physiol 587:1401-1411
20. Dardente H, Birnie M, Lincoln GA, Hazlerigg DG 2008 RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod. J Neuroendocrinol 20:1252-1259
21. Murakami M, Matsuzaki T, Iwasa T, Yasui T, Irahara M, Osugi T, Tsutsui K 2008 Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats. J Endocrinol 199:105-112
22. Rizwan MZ, Porteous R, Herbison AE, Anderson GM 2009 Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology 150:1413-1420
23. Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ 2009 Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology 150:5549-5556
24. Clarke IJ, Smith JT, Henry BA, Oldfield BJ, Stefanidis A, Millar RP, Sari IP, Chng K, Fabre-Nys C, Caraty A, Ang BT, Chan L, Fraley GS January 2012 Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology 10.1159/000332822
25. Clarke IJ 1995 Evidence that the switch from negative to positive feedback at the level of the pituitary gland is an important timing event for the onset of the preovulatory surge in LH in the ewe. J Endocrinol 145:271-282
26. Clarke IJ, Cummins JT, de Kretser DM 1983 Pituitary gland function after disconnection from direct hypothalamic influences in the sheep. Neuroendocrinology 36:376-384 (Pubitemid 13121958)
27. Clarke IJ, Cummins JT, Findlay JK, Burman KJ, Doughton BW 1984 Effects on plasma luteinizing hormone and follicle-stimulating hormone of varying the frequency and amplitude of gonadotropin-releasing hormone pulses in ovariectomized ewes with hypothalamo-pituitary disconnection. Neuroendocrinology 39:214-221 (Pubitemid 14054670)
28. Clarke IJ 2002 Two decades of measuring GnRH secretion. Reprod Suppl 59:1-13
29. Clarke IJ, Cummins JT 1985 Increased gonadotropin-releasing hormone pulse frequency associated with estrogen-induced luteinizing hormone surges in ovariectomized ewes. Endocrinology 116:2376-2383 (Pubitemid 15098071)
30. Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ 2008 Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology 149:1951-1959 (Pubitemid 351468347)
31. Roh SG, Doconto M, Feng DD, Chen C 2006 Differential regulation of GHRH-receptor and GHS-receptor expression by long-term in vitro treatment of ovine pituitary cells with GHRP-2 and GHRH. Endocrine 30:55-62 (Pubitemid 46020330)
32. Wu D, Chen C, Zhang J, Bowers CY, Clarke IJ 1996 The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs. J Endocrinol 148:197-205
33. Lee VW, Cumming IA, de Kretser DM, Findlay JK, Hudson B, Keogh EJ 1976 Regulation of gonadotrophin secretion in rams from birth to sexual maturity. I. Plasma LH, FSH and testosterone levels. J Reprod Fertil 46:1-6
34. Burger HG, Lee VW, Rennie GC 1972 A generalized computer program for the treatment of data from competitive protein-binding assays including radioimmunoassays. J Lab Clin Med 80:302-312
35. Kivipelto L, Majane EA, Yang HY, Panula P 1989 Immunohisto-chemical distribution and partial characterization of FLFQPQRF-amidelike peptides in the central nervous system of rats. J Comp Neurol 286:269-287 (Pubitemid 19220597)
36. Clarke IJ 1988 Gonadotrophin-releasing hormone secretion (GnRH) in anoestrous ewes and the induction of GnRH surges by oestrogen. J Endocrinol 117:355-360
37. Smith JT, Li Q, Yap KS, Shahab M, Roseweir AK, Millar RP, Clarke IJ 2011 Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence. Endocrinology 152:1001-1012
38. Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E 2008 An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology 149:4151-4157
39. Clarke I, Moore L, Veldhuis J 2002 Intensive direct cavernous sinus sampling identifies high-frequency, nearly random patterns of FSH secretion in ovariectomized ewes: combined appraisal by RIA and bioassay. Endocrinology 143:117-129 (Pubitemid 34056410)
40. Veldhuis JD, Johnson ML 1994 Testing pulse detection algorithms with simulations of episodically pulsatile substrate, metabolite, or hormone release. Methods Enzymol 240:377-415
41. Poling MC, Kim J, Dhamija S, Kauffman AS 2012 Development, sex steroid regulation, and phenotypic characterization of RFamiderelated peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology 153:1827-1840
42. Caraty A, Blomenrohr M, Vogel GM, Lomet D, Briant C, Beltramo M 27 January 2012 RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity. J Neuroendocrinol 10.1111/j.1365-2826.2012.02283.x
43. Ancel C, Bentsen AH, Sébert ME, Tena-Sempere M, Mikkelsen JD, Simonneaux V 2012 Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule. Endocrinology 153:1352-1363