Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Ubuka, Takayoshi ^a   Morgan, Kevin ^b   Pawson, Adam J ^b   Osugi, Tomohiro ^c   Chowdhury, Vishwajit S ^c   Minakata, Hiroyuki ^d   Tsutsui, Kazuyoshi ^c   Millar, Robert P ^b,e   Bentley, George E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c WASEDA UNIVERSITY   (Japan)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLPHENYLALANINAMIDE RELATED PEPTIDE 1; ARGINYLPHENYLALANINAMIDE RELATED PEPTIDE 3; GONADOTROPIN INHIBITORY HORMONE RECEPTOR 147; HORMONE RECEPTOR; NEUROPEPTIDE; UNCLASSIFIED DRUG; GLYCOPROTEIN; GONADOTROPIN INHIBITOR; MESSENGER RNA; NEUROPEPTIDE FF RECEPTOR; NEUROPEPTIDE RECEPTOR; RFAMIDE PEPTIDE;

ADULT; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GONADOTROPIN RELEASE; GONADOTROPIN SECRETING CELL; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PREOPTIC AREA; PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; AMINO ACID SEQUENCE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; METABOLISM; MOLECULAR GENETICS; NERVE CELL; SEQUENCE HOMOLOGY;

OVIS ARIES; PHASIANIDAE;

ADULT; AMINO ACID SEQUENCE; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MOLECULAR SEQUENCE DATA; NEURONS; NEUROPEPTIDES; PITUITARY-ADRENAL SYSTEM; RECEPTORS, NEUROPEPTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77949494829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008400     Document Type: Article

References (43)

1. Matsuo H, Baba Y, Nair RM, Arimura A, Schally AV (1971) Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun 43: 1334-1339.
2. Burgus R, Butcher M, Amoss M, Ling N, Monahan M, et al. (1972) Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide- Edman degradation). Proc Natl Acad Sci U S A 69: 278-282.
3. King JA, Millar RP (1982) Structure of chicken hypothalamic luteinizing hormone-releasing hormone. I. Structural determination on partially purified material. J Biol Chem 257: 10722-10728.
4. King JA, Millar RP (1982) Structure of chicken hypothalamic luteinizing hormone-releasing hormone. II. Isolation and characterization. J Biol Chem 257: 10729-10732.
5. Miyamoto K, Hasegawa Y, Minegishi T, Nomura M, Takahashi Y, et al. 1982 Isolation and characterization of chicken hypothalamic luteinizing hormone- releasing hormone. Biochem Biophys Res Commun 107: 820-827.
6. McCann SM, Porter JC (1969) Hypothalamic pituitary stimulating and inhibiting hormones. Physiol Rev 49: 240-284.
7. Hwan JC, Freeman ME (1987) Partial purification of a hypothalamic factor that inhibits gonadotropin-releasing hormone-stimulated luteinizing hormone release. Endocrinology 120: 483-490.
8. Balen AH, Er J, Rafferty B, Rose M (1995) In vitro bioactivity of gonadotrophin surge attenuating factor is not affected by an antibody to human inhibin. J Reprod Fertil 104: 285-289.
9. Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, et al. (2000) A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275: 661-667.
10. Ukena K, Ubuka T, Tsutsui K (2003) Distribution of a novel avian gonadotropininhibitory hormone in the quail brain. Cell Tissue Res 312: 73-79.
11. Ubuka T, Ueno M, Ukena K, Tsutsui K (2003) Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system. J Endocrinol 178: 311-318.
12. Satake H, Hisada M, Kawada T, Minakata H, Ukena K, et al. (2001) Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release. Biochem J 354: 379-385.
13. Osugi T, Ukena K, Bentley GE, O'Brien S, Moore IT, et al. (2004) Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow (Zonotrichia leucophrys gambelii): cDNA identification, transcript localization and functional effects in laboratory and field experiments. J Endocrinol 182: 33-42.
14. Yin H, Ukena K, Ubuka T, Tsutsui K (2005) A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity. J Endocrinol 184: 257-266.
15. Ciccone NA, Dunn IC, Boswell T, Tsutsui K, Ubuka T, et al. (2004) Gonadotrophin inhibitory hormone depresses gonadotrophin alpha and follicle- stimulating hormone beta subunit expression in the pituitary of the domestic chicken. J Neuroendocrinol 16: 999-1006.
16. Ubuka T, Ukena K, Sharp PJ, Bentley GE, Tsutsui K (2006) Gonadotropin- inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology 147: 1187-1194.
17. Bentley GE, Perfito N, Ukena K, Tsutsui K, Wingfield JC (2003) Gonadotropin- inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken- gonadotropin-releasing hormone. J Neuroendocrinol 15: 794-802.
18. Bentley GE, Jensen JP, Kaur GJ, Wacker DW, Tsutsui K, et al. (2006) Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH). Horm Behav 49: 550-555.
19. Ubuka T, Kim S, Huang YC, Reid J, Jiang J, et al. (2008) Gonadotropin- inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. Endocrinology 149:268-278. Erratum in: Endocrinology 149: 4229.
20. Ukena K, Tsutsui K (2005) A new member of the hypothalamic RF-amide peptide family, LPXRF-amide peptides: structure, localization, and function. Mass Spectrom Rev 24: 469-486.
21. Tsutsui K, Ukena K (2006) Hypothalamic LPXRF-amide peptides in vertebrates: identification, localization and hypophysiotropic activity. Peptides 27: 1121-1129.
22. Fukusumi S, Fujii R, Hinuma S (2006) Recent advances in mammalian RFamide peptides: the discovery and functional analyses of PrRP, RFRPs and QRFP. Peptides 27: 1073-1086.
23. Kriegsfeld LJ, Mei DF, Bentley GE, Ubuka T, Mason AO, et al. (2006) Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc Natl Acad Sci U S A 103: 2410-2415.
24. Johnson MA, Tsutsui K, Fraley GS (2007) Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav 51: 171-180.
25. Murakami M, Matsuzaki T, Iwasa T, Yasui T, Irahara M, et al. (2008) Hypophysiotropic role of RFamide-related peptide-3 (RFRP-3) in the inhibition of LH secretion in female rats. J Endocrinol 199: 105-112.
26. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, et al. (2008) Potent action of RFRP-3 on pituitary gonadotropes indicative of an hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 149: 5811-5821.
27. Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ (2009) Effect of RF-amide- related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology (in press).
28. Kadokawa H, Shibata M, Tanaka Y, Kojima T, Matsumoto K, et al. (2009) Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines. Domest Anim Endocrinol 36: 219-224.
29. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, et al. (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2: 703-708.
30. Ubuka T, McGuire NL, Calisi RM, Perfito N, Bentley GE (2008) The control of reproductive physiology and behavior by gonadotropin-inhibitory hormone. Integr Comp Biol 48: 560-569.
31. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, et al. (2008) Variation in kisspeptin and gonadotropin-inhibitory hormone expression and terminal connections to GnRH neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 149: 5770-5782.
32. Ubuka T, Lai H, Kitani M, Suzuuchi A, Pham V, et al. (2009) Gonadotropin- inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain. J Comp Neurol 517: 841-855.
33. Wu M, Dumalska I, Morozova E, van den Pol AN, Alreja M (2009) Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism. J Physiol 587.7: 1401-1411.
34. Ducret E, Anderson GM, Herbison AE (2009) RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone (GnRH) neuron firing in the mouse. Endocrinology 150: 2799-2804.
35. Anderson GM, Relf HL, Rizwan MZ, Evans JJ (2009) Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology 150: 1834-1840.
36. Ubuka T, Bentley GE, Ukena K, Wingfield JC, Tsutsui K (2005) Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain. Proc Natl Acad Sci U S A 102: 3052-3057.
37. Kirby ED, Geraghty AC, Ubuka T, Bentley GE, Kaufer D (2009) Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats. Proc Natl Acad Sci U S A 106: 11324-11329.
38. Emons G, Schally AV (1994) The use of luteinizing hormone releasing hormone agonists and antagonists in gynaecological cancers. Hum Reprod 9: 1364-1379.
39. Millar RP, Zhu YF, Chen C, Struthers RS (2000) Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications. Br Med Bull 56: 761-772.
40. Millar RP, Lu ZL, Pawson AJ, Flanagan CA, Morgan K, et al. (2004) Gonadotropin-releasing hormone receptors. Endocr Rev 25: 235-275.
41. Urbanski HF, Kim SO, Connolly ML (1990) Influence of photoperiod and 6- methoxybenzoxazolinone on the reproductive axis of inbred LSH/Ss Lak male hamsters. J Reprod Fertil 90: 157-163.
42. Ukena K, et al. (2003) Novel neuropeptides related to frog growth hormone- releasing peptide: isolation, sequence, and functional analysis. Endocrinology 144: 3879-3884.
43. Ukena K, Iwakoshi E, Minakata H, Tsutsui K (2002) A novel rat hypothalamic RFamide-related peptide identified by immunoaffinity chromatography and mass spectrometry. FEBS Lett 512: 255-258.