Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus

Endocrinology

Volumn 153, Issue 4, 2012, Pages 1827-1840

  Poling, Matthew C ^a   Kim, Joshua ^a   Dhamija, Sangeeta ^a   Kauffman, Alexander S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ARGININE PHENYLALANINE AMIDE RELATED PEPTIDE; GONADORELIN; NEUROPEPTIDE; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HORMONAL REGULATION; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUBERTY; REPRODUCTION; SEX DIFFERENCE;

AGING; ANDROGENS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; ESTROGENS; GONADAL STEROID HORMONES; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; NEURONS; NEUROPEPTIDES; PHENOTYPE; RECEPTORS, NEUROPEPTIDE; SEX CHARACTERISTICS;

EID: 84859377424     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-2049     Document Type: Article

References (49)

1. Tsutsui K 2009 A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance. Prog Neurobiol 88:76-88
2. Anderson GM, Relf HL, Rizwan MZ, Evans JJ 2009 Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats. Endocrinology 150:1834-1840
3. Ducret E, Anderson GM, Herbison AE 2009 RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology 150:2799-2804
4. Wu M, Dumalska I, Morozova E, van den Pol AN, Alreja M 2009 Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism. J Physiol 587:1401-1411
5. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M 2000 New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2:703-708
6. Kriegsfeld LJ, Mei DF, Bentley GE, Ubuka T, Mason AO, Inoue K, Ukena K, Tsutsui K, Silver R 2006 Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc Natl Acad Sci USA 103:2410-2415 (Pubitemid 43271683)
7. Ubuka T, Morgan K, Pawson AJ, Osugi T, Chowdhury VS, Minakata H, Tsutsui K, Millar RP, Bentley GE 2009 Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis. PLoS One 4:e8400
8. Smith JT, Shahab M, Pereira A, Pau KY, Clarke IJ 2010 Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate. Biol Reprod 83:568-577
9. Ukena K, Tsutsui K 2001 Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system. Neurosci Lett 300:153-156 (Pubitemid 32168210)
10. Yano T, Iijima N, Kakihara K, Hinuma S, Tanaka M, Ibata Y 2003 Localization and neuronal response of RFamide related peptides in the rat central nervous system. Brain Res 982:156-167 (Pubitemid 37281413)
11. Gibson EM, Humber SA, Jain S, Williams III WP, Zhao S, Bentley GE, Tsutsui K, Kriegsfeld LJ 2008 Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology 149:4958-4969
12. Quelven I, Roussin A, Zajac JM 2005 Comparison of pharmacological activities of neuropeptide FF1 and neuropeptide FF2 receptor agonists. Eur J Pharmacol 508:107-114 (Pubitemid 40169908)
13. Moulédous L, Mollereau C, Zajac JM 2010 Opioid-modulating properties of the neuropeptide FF system. Biofactors 36:423-429
14. Moulédous L, Barthas F, Zajac JM 2010 Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice. Neuropeptides 44:453-456
15. Johnson MA, Tsutsui K, Fraley GS 2007 Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav 51:171-180 (Pubitemid 44838645)
16. Murakami M, Matsuzaki T, Iwasa T, Yasui T, Irahara M, Osugi T, Tsutsui K 2008 Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats. J Endocrinol 199:105-112
17. Legagneux K, Bernard-Franchi G, Poncet F, La Roche A, Colard C, Fellmann D, Pralong F, Risold PY 2009 Distribution and genesis of the RFRP-producing neurons in the rat brain: comparison with melanin-concentrating hormone- and hypocretin-containing neurons. Neuropeptides 43:13-19
18. Quennell JH, Rizwan MZ, Relf HL, Anderson GM 2010 Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland. J Neuroendocrinol 22:309-316
19. Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Osugi T, Gereltsetseg G, Yoshida S, Irahara M, Tsutsui K 2011 Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus. Int J Dev Neurosci 30:31-37
20. Sethi S, Tsutsui K, Chaturvedi CM 2010 Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3 and testicular function in the mouse. Neuroendocrinology 91:189-199
21. Sethi S, Tsutsui K, Chaturvedi CM 2010 Age-dependent variation in the RFRP-3 neurons is inversely correlated with gonadal activity of mice. Gen Comp Endocrinol 168:326-332
22. Molnar CS, Kalló I, Liposits Z, Hrabovszky E 2011 Estradiol downregulates RF-amide-related peptide (RFRP) expression in the mouse hypothalamus. Endocrinology 152:1684-1690
23. Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams Jr DL, Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, Gould R, Austin CP 2001 Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. J Biol Chem 276:36961-36969
24. Mollereau C, Mazarguil H, Marcus D, Quelven I, Kotani M, Lannoy V, Dumont Y, Quirion R, Detheux M, Parmentier M, Zajac JM 2002 Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists. Eur J Pharmacol 451:245-256 (Pubitemid 35254027)
25. Yoshida H, Habata Y, Hosoya M, Kawamata Y, Kitada C, Hinuma S 2003 Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors. Biochim Biophys Acta 1593:151-157 (Pubitemid 36173483)
26. Gouardères C, Mazarguil H, Mollereau C, Chartrel N, Leprince J, Vaudry H, Zajac JM 2007 Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52:376-386 (Pubitemid 46123357)
27. Talmont F, Moulédous L, Piedra-Garcia L, Schmitt M, Bihel F, Bourguignon JJ, Zajac JM, Mollereau C 2010 Pharmacological characterization of the mouse NPFF2 receptor. Peptides 31:215-220
28. Ubuka T, Inoue K, Fukuda Y, Mizuno T, Kazyoshi U, Kriegsfeld LJ, Tsutsui K 2012 Identification, expression, and physiological functions of siberian hamster gonadotropin-inhibitory hormone. Endocrinology 153:373-385
29. Ubuka T, Kim S, Huang YC, Reid J, Jiang J, Osugi T, Chowdhury VS, Tsutsui K, Bentley GE 2008 Gonadotropin-inhibitory hormone neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in European starling brain. Endocrinology 149:268-278
30. Semaan SJ, Murray EK, Poling MC, Dhamija S, Forger NG, Kauffman AS 2010 BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology 151:5807-5817
31. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA 2005 Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686-3692 (Pubitemid 41175732)
32. Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, Steiner RA 2005 Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146:2976-2984 (Pubitemid 41002804)
33. Kim J, Semaan SJ, Clifton DK, Steiner RA, Dhamija S, Kauffman AS 2011 Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology 152:2020-2030
34. Finn PD, Steiner RA, Clifton DK 1998 Temporal patterns of gonadotropin-releasing hormone (GnRH), c-fos, and galanin gene expression in GnRH neurons relative to the luteinizing hormone surge in the rat. J Neurosci 18:713-719 (Pubitemid 28041907)
35. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA 2004 A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077 (Pubitemid 39120554)
36. Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M 2007 Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148:1774-1783 (Pubitemid 46457121)
37. Robertson JL, Clifton DK, de la Iglesia HO, Steiner RA, Kauffman AS 2009 Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge. Endocrinology 150:3664-3671
38. Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, van Noort PI, Tena-Sempere M 2010 Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. Endocrinology 151:1902-1913
39. Kauffman AS, Navarro VM, Kim J, Clifton D, Steiner RA 2009 Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for the timing of puberty. Am J Physiol Endocrinol Metab 297:E1212-E1221
40. Semaan SJ, Kauffman AS 2010 Sexual differentiation and development of forebrain reproductive circuits. Curr Opin Neurobiol 20:424-431
41. Gouardères C, Kieffer BL, Zajac JM 2004 Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains. J Chem Neuroanat 27:119-128 (Pubitemid 38581107)
42. Gouardères C, Puget A, Zajac JM 2004 Detailed distribution of neuropeptide FF receptors (NPFF1 and NPFF2) in the rat, mouse, octodon, rabbit, guinea pig, and marmoset monkey brains: a comparative autoradiographic study. Synapse 51:249-269 (Pubitemid 38140898)
43. Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA 2004 Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272 (Pubitemid 40187012)
44. Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, Rissman EF 2007 The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci 27:8826-8835 (Pubitemid 47292767)
45. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN 2008 Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 149:5770-5782
46. Sugrue ML, Vella KR, Morales C, Lopez ME, Hollenberg AN 2010 The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo. Endocrinology 151:793-801
47. White FA, Keller-Peck CR, Knudson CM, Korsmeyer SJ, Snider WD 1998 Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J Neurosci 18:1428-1439 (Pubitemid 28082428)
48. Kaewwongse M, Takayanagi Y, Onaka T 2011 Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. J Neuroendocrinol 23:20-27
49. Simonin F, Schmitt M, Laulin JP, Laboureyras E, Jhamandas JH, MacTavish D, Matifas A, Mollereau C, Laurent P, Parmentier M, Kieffer BL, Bourguignon JJ, Simonnet G 2006 RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci USA 103:466-471 (Pubitemid 43122424)