Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: Reduced appetite for calories and suppression of addictive-like behaviors

Pharmacology Biochemistry and Behavior

Volumn 102, Issue 3, 2012, Pages 400-406

  Karlsson, Camilla ^a   Zook, Michelle ^a   Ciccocioppo, Roberto ^b   Gehlert, Donald R ^c   Thorsell, Annika ^a   Heilig, Markus ^a   Cippitelli, Andrea ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF CAMERINO   (Italy)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Binging; Intermittent; MCH1 R; Reinstatement; Saccharin; Sucrose

Indexed keywords

GW 803430; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; SACCHARIN; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINGE EATING DISORDER; CALORIC INTAKE; CONTROLLED STUDY; DECREASED APPETITE; DOSE RESPONSE; DRUG MEGADOSE; ENERGY BALANCE; FOOD ADDICTION; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; SELF MEDICATION; STATISTICAL SIGNIFICANCE; SUGAR INTAKE;

ANIMALS; APPETITE; BEHAVIOR, ADDICTIVE; CARBOHYDRATES; CONDITIONING, OPERANT; CUES; ENERGY INTAKE; ENVIRONMENT; MALE; MOTIVATION; PYRIMIDINONES; RATS; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; RECURRENCE; REINFORCEMENT SCHEDULE; SACCHARIN; SELF ADMINISTRATION; THIOPHENES;

ANIMALIA; RATTUS;

EID: 84862686660     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.06.010     Document Type: Article

References (44)

1. J.M. Arnold, and D.C. Roberts A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement Pharmacol Biochem Behav 57 1997 441 447 (Pubitemid 27296755)
2. N.M. Avena, and B.G. Hoebel A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine Neuroscience 122 2003 17 20 (Pubitemid 37329944)
3. M. Avena, P. Rada, and B.G. Hoebel Sugar bingeing in rats Curr Protoc Neurosci 2006 Aug Chapter 9:Unit9.23C.
4. N.M. Avena, P. Rada, and B.G. Hoebel Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake Neurosci Biobehav Rev 32 2008 20 39 (Pubitemid 350160955)
5. J.R. Barson, I. Morganstern, and S.F. Leibowitz Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol Physiol Behav 104 1 2011 Jul 25 128 137
6. S.C. Benoit, D.J. Clegg, S.C. Woods, and R.J. Seeley The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides Peptides 26 2005 751 757 (Pubitemid 40461656)
7. J.C. Bittencourt, F. Presse, C. Arias, C. Peto, J. Vaughan, and J.L. Nahon The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization J Comp Neurol 319 1992 218 245
8. S. Chung, F.W. Hopf, H. Nagasaki, C.Y. Li, J.D. Belluzzi, and A. Bonci The melanin-concentrating hormone system modulates cocaine reward Proc Natl Acad Sci 106 2009 6772
9. S. Chung, G.S. Parks, C. Lee, and O. Civelli Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists J Mol Neurosci 43 2011 115 121
10. A. Cippitelli, A. Bilbao, A.C. Hansson, I. Del Arco, W. Sommer, and M. Heilig Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats Eur J Neurosci 21 2005 2243 2251 (Pubitemid 40695249)
11. A. Cippitelli, A. Bilbao, M.A. Gorriti, M. Navarro, M. Massi, and D. Piomelli The anandamide transport inhibitor AM404 reduces ethanol self-administration Eur J Neurosci 26 2007 476 486 (Pubitemid 47087610)
12. A. Cippitelli, C. Karlsson, J.L. Shaw, A. Thorsell, D.R. Gehlert, and M. Heilig Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats Psychopharmacology 2010 1 9
13. C. Colantuoni, J. Schwenker, J. McCarthy, P. Rada, B. Ladenheim, and J.L. Cadet Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain Neuroreport 12 2001 3549
14. P. Cottone, V. Sabino, M. Roberto, M. Bajo, L. Pockros, and J.B. Frihauf CRF system recruitment mediates dark side of compulsive eating Proc Natl Acad Sci 106 2009 20016
15. S.C. de Vaca, and K.D. Carr Food restriction enhances the central rewarding effect of abused drugs J Neurosci 18 1998 7502 7510 (Pubitemid 28425832)
16. R.J. DiLeone, D. Georgescu, and E.J. Nestler Lateral hypothalamic neuropeptides in reward and drug addiction Life Sci 73 2003 759 768 (Pubitemid 36703270)
17. E.A. Duncan, K. Proulx, and S.C. Woods Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats Alcohol Clin Exp Res 29 2005 958 964 (Pubitemid 40934199)
18. E.A. Duncan, T.R. Rider, R.J. Jandacek, D.J. Clegg, S.C. Benoit, and P. Tso The regulation of alcohol intake by melanin-concentrating hormone in rats Pharmacol Biochem Behav 85 2006 728 735 (Pubitemid 46149004)
19. C. Erlanson-Albertsson How palatable food disrupts appetite regulation Basic Clin Pharmacol Toxicol 97 2005 61 73 (Pubitemid 41021104)
20. D.R. Gehlert, K. Rasmussen, J. Shaw, X. Li, P. Ardayfio, and L. Craft Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression J Pharmacol Exp Ther 329 2009 429
21. D. Georgescu, R.M. Sears, J.D. Hommel, M. Barrot, C.A. Bolanos, and D.J. Marsh The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance J Neurosci 25 2005 2933 2940 (Pubitemid 40389251)
22. A. Gomori, A. Ishihara, M. Ito, S. Mashiko, H. Matsushita, and M. Yumoto Chronic intracerebroventricular infusion of MCH causes obesity in mice Am J Physiol Endocrinol Metab 284 2003 E583 E588
23. D.L. Hertzog, K.A. Al-Barazanji, E.C. Bigham, M.J. Bishop, C.S. Britt, and D.L. Carlton The discovery and optimization of pyrimidinone-containing MCH R1 antagonists Bioorg Med Chem Lett 16 2006 4723 4727 (Pubitemid 44175869)
24. H. Kawauchi, I. Kawazoe, M. Tsubokawa, M. Kishida, and B.I. Baker Characterization of melanin-concentrating hormone in chum salmon pituitaries Nature 305 1983 321 323 (Pubitemid 13010926)
25. A.D. Le, S. Harding, W. Juzytsch, D. Funk, and Y. Shaham Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats Psychopharmacology 179 2005 366 373
26. C. Morens, P. Norregaard, J.M. Receveur, G. van Dijk, and A.J.W. Scheurink Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake Brain Res 1062 2005 32 38 (Pubitemid 41612126)
27. J.D. Mul, S.E. La Fleur, P.W. Toonen, A. Afrasiab-Middelman, R. Binnekade, and D. Schetters Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat PLoS One 6 2011 e19600
28. S.G. Nair, T. Adams-Deutsch, C.L. Pickens, D.G. Smith, and Y. Shaham Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats Psychopharmacology 205 2009 129 140
29. D.E. Pankevich, S.L. Teegarden, A.D. Hedin, C.L. Jensen, and T.L. Bale Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating J Neurosci 30 2010 16399 16407
30. P. Pissios, L. Frank, A.R. Kennedy, D.R. Porter, F.E. Marino, and F.F. Liu Dysregulation of the mesolimbic dopamine system and reward in MCH -/- mice Biol Psychiatry 64 2008 184 191
31. F. Presse, J.L. Nahon, W.H. Fischer, and W. Vale Structure of the human melanin concentrating hormone mRNA Mol Endocrinol 4 1990 632 637
32. D. Qu, D.S. Ludwig, S. Gammeltoft, M. Piper, M.A. Pelleymounter, M.J. Cullen, W.F. Mathes, J. Przypek, and R. Kanarek Maratos-Flier E (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour Nature 380 6571 1996 Mar 21 243 247 (Pubitemid 26090645)
33. P. Rada, N.M. Avena, and B.G. Hoebel Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell Neuroscience 134 2005 737 744 (Pubitemid 41133378)
34. Y. Saito, M. Cheng, F.M. Leslie, and O. Civelli Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain J Comp Neurol 435 2001 26 40 (Pubitemid 32448720)
35. R. Sakamaki, M. Uemoto, A. Inui, A. Asakawa, N. Ueno, and C. Ishibashi Melanin-concentrating hormone enhances sucrose intake Int J Mol Med 15 2005 1033 1039
36. C.B. Saper, T.C. Chou, and J.K. Elmquist The need to feed: homeostatic and hedonic control of eating Neuron 36 2002 199 211 (Pubitemid 35217887)
37. U. Shalev, J.W. Grimm, and Y. Shaham Neurobiology of relapse to heroin and cocaine seeking: a review Pharmacol Rev 54 2002 1 42 (Pubitemid 34208828)
38. Y. Shi Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions Peptides 25 2004 1605 1611 (Pubitemid 39346202)
39. D.G. Smith, E.T. Tzavara, J. Shaw, S. Luecke, M. Wade, and R. Davis Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice J Neurosci 25 2005 914 922 (Pubitemid 40171007)
40. C.P. Tan, H. Sano, H. Iwaasa, J. Pan, A.W. Sailer, and D.L. Hreniuk Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression Genomics 79 2002 785 792 (Pubitemid 34595312)
41. J.M. Vaughan, W.H. Fischer, C. Hoeger, J. Rivier, and W. Vale Characterization of melanin-concentrating hormone from rat hypothalamus Endocrinology 125 1989 1660
42. L.F. Vendruscolo, A.B. Gueye, M. Darnaudéry, S.H. Ahmed, and M. Cador Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats PLoS One 5 2010 e9296
43. N.D. Volkow, and R.A. Wise How can drug addiction help us understand obesity? Nat Neurosci 8 2005 555 560 (Pubitemid 40594193)
44. R.A. Wise Dopamine, learning and motivation Nat Rev Neurosci 5 2004 483 494 (Pubitemid 38715515)