Engineering corynebacterium glutamicum for the production of pyruvate

Applied Microbiology and Biotechnology

Volumn 94, Issue 2, 2012, Pages 449-459

  Wieschalka, Stefan ^a   Blombach, Bastian ^b   Eikmanns, Bernhard J ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Acetohydroxyacid synthase; Corynebacterium glutamicum; Industrial biotechnology; NAD + dependent L lactate dehydrogenase; Pyruvate dehydrogenase complex; Pyruvate production; Pyruvate: quinone oxidoreductase; Transaminases

Indexed keywords

ACETOHYDROXYACID SYNTHASE; CORYNEBACTERIUM GLUTAMICUM; INDUSTRIAL BIOTECHNOLOGY; L-LACTATE; OXIDOREDUCTASES; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE PRODUCTION; TRANSAMINASES;

CHARGE DENSITY WAVES; FERMENTATION; GENE ENCODING; GLUCOSE;

AMINO ACIDS;

PYRUVIC ACID;

BACTERIUM; BIOTECHNOLOGY; DISSOLVED OXYGEN; ENGINEERING; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE; GROWTH RATE; INDUSTRIAL PRODUCTION; METABOLISM; MUTATION; OXYGEN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOENGINEERING; BIOREACTOR; CELL DENSITY; CORYNEBACTERIUM GLUTAMICUM; FED BATCH FERMENTATION; GENE DELETION; NONHUMAN;

CORYNEBACTERIUM GLUTAMICUM; GENE DELETION; GENE EXPRESSION; GLUCOSE; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; PYRUVIC ACID; VALINE;

CORYNEBACTERIUM GLUTAMICUM;

EID: 84862685293     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3843-9     Document Type: Article

References (59)

1. Blombach B, Schreiner ME, Moch M, Oldiges M, Eikmanns BJ (2007a) Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum. Appl Microbiol Biotechnol 76:615-623 (Pubitemid 47283123)
2. Blombach B, Schreiner ME, Holátko J, Bartek T, Oldiges M, Eikmanns BJ (2007b) L-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl Environ Microbiol 73:2079-2084 (Pubitemid 46649496)
3. Blombach B, Schreiner ME, Bartek T, Oldiges M, Eikmanns BJ (2008) Corynebacterium glutamicum tailored for high-yield L-valine production. Appl Microbiol Biotechnol 79:471-479 (Pubitemid 351704103)
4. Blombach B, Stephan H, Brigitte B, Eikmanns BJ (2009) Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum. Appl Environ Microbiol 75:419-427
5. Blombach B, Riester T, Wieschalka S, Ziert C, Youn JW, Wendisch VF, Eikmanns BJ (2011) Corynebacterium glutamicum tailored for efficient isobutanol production. Appl Environ Microbiol 77:3300-3310
6. Causey TB, Shanmugam KT, Yomano LP, Ingram LO (2004) Engineering Escherichia coli for efficient conversion of glucose to pyruvate. Proc Natl Acad Sci USA 101:2235-2240 (Pubitemid 38269295)
7. Cicalese L, Hierholzer C, Subbotin V, Iyengar A, Rao AS, Stanko RT (1997) Protective effect of pyruvate during acute rejection of intestinal allografts: accompanied by up-regulation of inducible nitric oxide synthase mRNA. Transplant Proc 29:1813-1814 (Pubitemid 27203683)
8. Cicalese L, Subbotin V, Rastellini C, Stanko RT, Rao AS, Fung JJ (1999) Preservation injury and acute rejection of rat intestinal grafts: protection afforded by pyruvate. J Gastrointest Surg 3:549-554
9. Cotellessa C, Manunta T, Ghersetich I, Brazzini B, Peris K (2004) The use of pyruvic acid in the treatment of acne. J Eur Acad Dermatol Venereol 18:275-278 (Pubitemid 38618321)
10. DeBoer LW, Bekx PA, Han L, Steinke L (1993) Pyruvate enhances recovery of rat hearts after ischemia and reperfusion by preventing free radical generation. Am J Physiol 265:1571-1576
11. Dower WJ, Miller JF, Ragsdale CW (1988) High efficiency transformation of E. coli by high voltage electroporation. Nucleic Acids Res 16:6127-6145
12. Eggeling L, Bott M (2005) Handbook of Corynebacterium glutamicum. CRC Press, Boca Raton, USA, pp 13-16
13. Eikmanns BJ, Metzger M, Reinscheid D, Kircher M, Sahm H (1991) Amplification of three threonine biosynthesis genes in Corynebacterium glutamicum and its influence on carbon flux in different strains. Appl Microbiol Biotechnol 34:617-622
14. Eikmanns BJ, Thum-Schmitz N, Eggeling L, Lüdtke KU, Sahm H (1994) Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828 (Pubitemid 24259015)
15. Ghersetich I, Brazzini B, Peris K, Cotellessa C, Manunta T, Lotti T (2004) Pyruvic acid peels for the treatment of photoaging. Dermatol Surg 30:32-36 (Pubitemid 38174025)
16. Hanahan D (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166:557-580 (Pubitemid 13027898)
17. Howard JW, Fraser WA (1932) Preparation of pyruvic acid. Org Synth Coll 1:475-480
18. Inui M, Murakami S, Okino S, Kawaguchi H, Vertès AA, Yukawa H (2004a) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol 7:182-196 (Pubitemid 39294707)
19. Inui M, Kawaguchi H, Murakami S, Vertès AA, Yukawa H (2004b) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen deprivation-conditions. J Mol Microbiol Biotechnol 8:243-254 (Pubitemid 41368969)
20. Jolkver E, Emer D, Ballan S, Krämer R, Eikmanns BJ, Marin K (2009) Identification and characterization of a bacterial transport system for the uptake of pyruvate, propionate, and acetate in Corynebacterium glutamicum. J Bacteriol 191:940-948
21. Kato O, Youn JW, Stansen KC, Matsui D, Oikawa T, Wendisch VF (2010) Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiol 10:1471-2180
22. Krause FS, Blombach B, Eikmanns BJ (2010) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl Environ Microbiol 76:8053-8061
23. Lamprecht W, Heinz F (1983) Pyruvate. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol VI, 3rd edn. Verlag Chemie Weinheim, Germany, pp 570-577
24. Leuchtenberger W, Huthmacher K, Drauz K (2005) Biotechnological production of amino acids and derivatives: current status and prospects. Appl Microbiol Biotechnol 69:1-8 (Pubitemid 41719169)
25. Li Y, Chen J, Lun SY (2001) Biotechnological production of pyruvic acid. Appl Microbiol Biotechnol 57:451-459 (Pubitemid 33044118)
26. Liebl W (2006) The genus Corynebacterium-nonmedical. In: Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E (eds) The prokaryotes, vol 3, 3rd edn. Springer, New York, pp 796-818
27. Litsanov B, Kabus A, Brocker M, Bott M (2011) Efficient aerobic succinate production from glucose in minimal medium with Corynebacterium glutamicum. Microb Biotechnol, Epub ahead of print. doi:10.1111/j.1751-7915.2011.00310.x
28. Marienhagen J, Eggeling L (2008) Metabolic function of Corynebacterium glutamicum aminotransferases AlaT and AvtA and impact on L-valine production. Appl Environ Microbiol 74:7457-7462
29. Marienhagen J, Kennerknecht N, Sahm H, Eggeling L (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum. J Bacteriol 187:7639-46 (Pubitemid 41587702)
30. Martìnez I, Bennett GN, San KY (2010) Metabolic impact of the level of aeration during cell growth on anaerobic succinate production by an engineered Escherichia coli strain. Metab Eng 12:499-509
31. Mimitsuka T, Sawai H, Hatsu M, Yamada K (2007) Metabolic engineering of Corynebacterium glutamicum for cadaverin fermentation. Biosci Biotechnol Biochem 71:2130-2135 (Pubitemid 350113121)
32. Nishimura T, Vertès AA, Shinoda Y, Inui M, Yukawa H (2007) Anaerobic growth of Corynebacterium glutamicum using nitrate as a terminal electron acceptor. Appl Microbiol Biotechnol 75:889-897 (Pubitemid 47164900)
33. Okino S, Noburyu R, Suda M, Jojima T, Inui M, Yukawa H (2008a) An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain. Appl Microbiol Biotechnol 81:459-464
34. Okino S, Suda M, Fujikura K, Inui M, Yukawa H (2008b) Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 78:449-454
35. Peters-Wendisch PG, Wendisch VF, Paul S, Eikmanns BJ, Sahm H (1997) Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum. Microbiology 143:1095-1103 (Pubitemid 27207778)
36. Peters-Wendisch PG, Kreutzer C, Kalinowski J, Pátek M, Sahm H, Eikmanns BJ (1998) Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene. Microbiology 144:915-927 (Pubitemid 28187917)
37. Roufs JB (1996) Pyruvate: does it amp endurance and burn more fat? Muscle Fitness 57:195-197
38. Sasaki M, Jojima T, Inui M, Yukawa H (2010) Xylitol production by recombinant Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 86:1057-1066
39. Sauer U, Eikmanns BJ (2005) The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria. FEMS Microbiol Rev 29:765-794 (Pubitemid 41149049)
40. Schäfer A, Tauch A, Jäger W, Kalinowski J, Thierbach G, Pühler A (1994) Small mobilizable multi-purpose cloning vectors derived from the E. coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145:69-73 (Pubitemid 24224965)
41. Schneider J, Wendisch VF (2010) Putrescine production by engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol 88:859-868
42. Schneider J, Wendisch VF (2011) Biotechnological production of polyamines by bacteria: recent achievements and future perspectives. Appl Microbiol Biotechnol 91:17-30
43. Schreiner ME, Fiur D, Holátko J, Pätek M, Eikmanns BJ (2005) E1 enzyme of the pyruvate dehydrogenase complex in Corynebacterium glutamicum: molecular analysis of the gene and phylogenetic aspects. J Bacteriol 187:6005-6018 (Pubitemid 41262798)
44. Schreiner ME, Riedel C, Holátko J, Patek M, Eikmanns BJ (2006) Pyruvate:quinone oxidoreductase in Corynebacterium glutamicum: molecular analysis of the pqo gene, significance of the enzyme, and phylogenetic aspects. J Bacteriol 188:1341-1350 (Pubitemid 43228667)
45. Sekine H, Shimada T, Hayashi C, Ishiguro A, Tomita F, Yokota A (2001) H+-ATPase defect in Corynebacterium glutamicum abolishes glutamic acid production with enhancement of glucose consumption rate. Appl Microbiol Biotechnol 57:534-540 (Pubitemid 33044132)
46. Smith KM, Cho KM, Liao JC (2010) Engineering Corynebacterium glutamicum for isobutanol production. Appl Microbiol Biotechnol 87:1045-1055
47. Stanko RT, Robertson RJ, Galbreath RW, Reilly JJ, Greenawalt KD, Goss FL (1990) Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate. J Appl Physiol 69:1651-1656
48. Stanko RT, Tietze DL, Arch JE (1992a) Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate. Am J Clin Nutr 55:771-776
49. Stanko RT, Tietze DL, Arch JE (1992b) Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. Am J Clin Nutr 56:630-635
50. Stansen C, Uy D, Delaunay S, Eggeling L, Goergen JL, Wendisch VF (2005) Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production. Appl Environ Microbiol 71:5920-5928 (Pubitemid 41456885)
51. Takors R, Bathe B, Rieping M, Hans S, Kelle R, Huthmacher K (2007) Systems biology for industrial strains and fermentation processes -example: amino acids. J Biotechnol 129:181-190 (Pubitemid 46546600)
52. van der Rest ME, Lange C, Molenaar D (1999) A heat shock following electroporation induces highly efficient transformation of Corynebacterium glutamicum with xenogenic plasmid DNA. Appl Microbiol Biotechnol 52:541-545 (Pubitemid 29513334)
53. Veit A, Rittmann D, Georgi T, Youn JW, Eikmanns BJ, Wendisch VF (2009) Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum. J Biotechnol 140:75-83
54. Wendisch VF, Bott M, Eikmanns BJ (2006) Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for biotechnological production of organic acids and amino acids. Curr Opin Microbiol 9:268-274
55. Yokota A, Shimizu H, Terasawa Y, Takaoka N, Tomita F (1994a) Pyruvic acid production by a lipoic acid auxotroph of Escherichia coli W1485. Appl Microbiol Biotechnol 41:638-646
56. Yokota A, Terasawa Y, Takaoka N, Shimizu H, Tomita F (1994b) Pyruvic acid production by an F1-ATPase-defective mutant of Escherichia coli W1485lip2. Biosci Biotechnol Biochem 58:2164-2167
57. Zelić B, Gerharz T, Bott M, Vasić-Rački D, Wandrey C, Takors R (2003) Fed-batch process for pyruvate production by recombinant Escherichia coli YYC202 strain. Eng in Life Sci 3:299-305 (Pubitemid 37036245)
58. Zhu Y, Eiteman MA, Altman R, Altman E (2008) High glycolytic flux improves pyruvate production by a metabolically engineered Escherichia coli strain. Appl Environ Microbiol 74:6649-6655
59. Zimmermann HF, Anderlei T, Büchs J, Binder M (2006) Oxygen limitation is a pitfall during screening for industrial strains. Appl Microbiol Biotechnol 72:1157-1160 (Pubitemid 44564449)