Post-training unilateral amygdala lesions selectively impair contextual fear memories

Learning and Memory

Volumn 19, Issue 6, 2012, Pages 256-263

  Flavell, Charlotte R ^a   Lee, Jonathan L C ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL AMYGDALA; BRAIN DAMAGE; CONDITIONING; CONTROLLED STUDY; DORSAL HIPPOCAMPUS; EXCITOTOXICITY; FEAR CONDITIONING; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACOUSTIC STIMULATION; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, CLASSICAL; ELECTROSHOCK; FEAR; FUNCTIONAL LATERALITY; HIPPOCAMPUS; MALE; MEMORY DISORDERS; PROTO-ONCOGENE PROTEINS C-FOS; QUINOLINIC ACID; RATS;

EID: 84862673750     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.025403.111     Document Type: Article

References (39)

1. Anagnostaras SG, Gale GD, Fanselow MS. 2001. Hippocampus and contextual fear conditioning: Recent controversies and advances. Hippocampus 11: 8-17.
2. Baker KB, Kim JJ. 2004. Amygdalar lateralization in fear conditioning: Evidence for greater involvement of the right amygdala. Behav Neurosci 118: 15-23. (Pubitemid 38222520)
3. Blanchard RJ, Blanchard DC. 1969. Crouching as an index of fear. J Comp Physiol Psychol 67: 370-375.
4. Bortolanza M, Wietzikoski EC, Boschen SL, Dombrowski PA, Latimer M, Maclaren DA,Winn P, Da Cunha C. 2010. Functional disconnection of the substantia nigra pars compacta from the pedunculopontine nucleus impairs learning of a conditioned avoidance task. Neurobiol Learn Mem 94: 229-239.
5. Cousens G, Otto T. 1998. Both pre- and post-training excitotoxic lesions of the basolateral amygdala abolish the expression of olfactory and contextual fear conditioning. Behav Neurosci 112: 1092-1103. (Pubitemid 28518992)
6. Dragunow M, Faull R. 1989. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods 29: 261-265. (Pubitemid 19222725)
7. Fanselow MS. 2000. Contextual fear, gestalt memories, and the hippocampus. Behav Brain Res 110: 73-81. (Pubitemid 30236293)
8. Fendt M, Fanselow MS. 1999. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci Biobehav Rev 23: 743-760. (Pubitemid 29282023)
9. Fendt M, Fanselow MS, Koch M. 2005. Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle. Behav Neurosci 119: 834-838. (Pubitemid 40934375)
10. Ferreira TL, Shammah-Lagnado SJ, Bueno OF, Moreira KM, Fornari RV, Oliveira MG. 2008. The indirect amygdala-dorsal striatum pathway mediates conditioned freezing: Insights on emotional memory networks. Neuroscience 153: 84-94.
11. Frankland PW, Cestari V, Filipkowski RK, McDonald RJ, Silva AJ. 1998. The dorsal hippocampus is essential for context discrimination but not for contextual conditioning. Behav Neurosci 112: 863-874. (Pubitemid 28397368)
12. Glenn MJ, Lehmann H, Mumby DG, Woodside B. 2005. Differential fos expression following aspiration, electrolytic, or excitotoxic lesions of the perirhinal cortex in rats. Behav Neurosci 119: 806-813. (Pubitemid 40934372)
13. Goosens KA, Maren S. 2001. Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learn Mem 8: 148-155. (Pubitemid 32552863)
14. Ito R, Robbins TW, McNaughton BL, Everitt BJ. 2006. Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure. Eur J Neurosci 23: 3071-3080. (Pubitemid 43882887)
15. Iwata J, LeDoux JE, MeeleyMP, Arneric S, Reis DJ. 1986. Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli. Brain Res 383: 195-214. (Pubitemid 17179977)
16. Jimenez SA, Maren S. 2009. Nuclear disconnection within the amygdala reveals a direct pathway to fear. Learn Mem 16: 766-768.
17. Kaczmarek L. 1993. Molecular biology of vertebrate learning: Is c-fos a new beginning? J Neurosci Res 34: 377-381. (Pubitemid 23081782)
18. Kim JJ, Rison RA, Fanselow MS. 1993. Effects of amygdala, hippocampus, and periaqueductal gray lesions on short- and long-term contextual fear. Behav Neurosci 107: 1093-1098. (Pubitemid 24018220)
19. LaBar KS, LeDoux JE. 1996. Partial disruption of fear conditioning in rats with unilateral amygdala damage: Correspondence with unilateral temporal lobectomy in humans. Behav Neurosci 110: 991-997. (Pubitemid 26365797)
20. Lashley KS. 1931. Mass action in cerebral function. Science 73: 245-254.
21. LeDoux JE. 2000. Emotion circuits in the brain. Annu Rev Neurosci 23: 155-184. (Pubitemid 30350041)
22. LeDoux JE, Iwata J, Pearl D, Reis DJ. 1986a. Disruption of auditory but not visual learning by destruction of intrinsic neurons in the rat medial geniculate body. Brain Res 371: 395-399. (Pubitemid 16082924)
23. LeDoux JE, Sakaguchi A, Iwata J, Reis DJ. 1986b. Interruption of projections from the medial geniculate body to an archi-neostriatal field disrupts the classical conditioning of emotional responses to acoustic stimuli. Neuroscience 17: 615-627. (Pubitemid 16131260)
24. LeDoux JE, Farb C, Ruggiero DA. 1990. Topographic organization of neurons in the acoustic thalamus that project to the amygdala. J Neurosci 10: 1043-1054.
25. Maren S. 1999. Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats. J Neurosci 19: 8696-8703. (Pubitemid 30226788)
26. Maren S. 2001. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24: 897-931.
27. Maren S, Aharonov G, Fanselow MS. 1996. Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: Absence of a temporal gradient. Behav Neurosci 110: 718-726. (Pubitemid 26262447)
28. Maren S, Aharonov G, Fanselow MS. 1997. Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88: 261-274. (Pubitemid 27496322)
29. Maren S, Anagnostaras SG, Fanselow MS. 1998. The startled seahorse: Is the hippocampus necessary for contextual fear conditioning? Trends Cogn Sci 2: 39-42. (Pubitemid 28389557)
30. Markham CM, Taylor SL, Huhman KL. 2010. Role of amygdala and hippocampus in the neural circuit subserving conditioned defeat in Syrian hamsters. Learn Mem 17: 109-116.
31. McDonald AJ. 1998. Cortical pathways to the mammalian amygdala. Prog Neurobiol 55: 257-332.
32. Paxinos G,Watson C. 2007. The rat brain in stereotaxic coordinates. Academic Press, London.
33. Phillips RG, LeDoux JE. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106: 274-285.
34. Pitkanen A, Pikkarainen M, Nurminen N, Ylinen A. 2000. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann N Y Acad Sci 911: 369-391. (Pubitemid 30462094)
35. Rudy JW, O'Reilly RC. 1999. Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus. Behav Neurosci 113: 867-880. (Pubitemid 30130863)
36. Selden NR, Everitt BJ, Jarrard LE, Robbins TW. 1991. Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience 42: 335-350.
37. Wallace KJ, Rosen JB. 2001. Neurotoxic lesions of the lateral nucleus of the amygdala decrease conditioned fear but not unconditioned fear of a predator odor: Comparison with electrolytic lesions. J Neurosci 21: 3619-3627. (Pubitemid 32422826)
38. Wiltgen BJ, Sanders MJ, Anagnostaras SG, Sage JR, Fanselow MS. 2006. Context fear learning in the absence of the hippocampus. J Neurosci 26: 5484-5491. (Pubitemid 44318400)
39. Zimmerman JM, Rabinak CA, McLachlan IG, Maren S. 2007. The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learn Mem 14: 634-644. (Pubitemid 47481697)