Swift residue-screening identifies key N-glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo-1

FEBS Letters

Volumn 583, Issue 6, 2009, Pages 1034-1038

  Zhong, Xiaotian ^a   Pocas, Jennifer ^a   Liu, Yan ^a   Wu, Paul W ^a   Mosyak, Lidia ^a   Somers, Will ^a   Kriz, Ron ^a  

^a PFIZER INC   (United States)

Author keywords

Glycosylation; Mammalian transient expression; Neuroglycoprotein; Residue screening; Surface expression

Indexed keywords

ASPARAGINE; GLYCOPROTEIN; GLYCOPROTEIN LINGO 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MAMMAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; SCREENING TEST; STRUCTURE ANALYSIS; SURFACE PROPERTY; SWIFT RESIDUE SCREENING;

ANTIGENS, SURFACE; ASPARAGINE; CELL MEMBRANE; CELLS, CULTURED; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PLASMIDS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, PROTEIN; TIME FACTORS;

MAMMALIA;

EID: 61749096009     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.02.034     Document Type: Article

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