Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1-mediated p53 activation

Journal of Cellular Physiology

Volumn 227, Issue 10, 2012, Pages 3363-3372

  Gu, Guowei ^a   Barone, Ines ^b   Gelsomino, Luca ^b   Giordano, Cinzia ^b   Bonofiglio, Daniela ^b   Statti, Giancarlo ^b   Menichini, Francesco ^b   Catalano, Stefania ^b   Andò, Sebastiano ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR ALPHA; OLDENLANDIA DIFFUSA EXTRACT; OLEANOLIC ACID DERIVATIVE; PLANT EXTRACT; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; URSOLIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL DESTRUCTION; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA FRAGMENTATION; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; OLDENLANDIA DIFFUSA; OPTICAL DENSITY; PRIORITY JOURNAL; PROMOTER REGION;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG RESISTANCE, NEOPLASM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULINS; OLDENLANDIA; OLEANOLIC ACID; PLANT EXTRACTS; PROMOTER REGIONS, GENETIC; TAMOXIFEN; TRANSCRIPTIONAL ACTIVATION; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84862661308     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24035     Document Type: Article

References (38)

1. Aggarwal BB, Shishodia S. 2006. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421.
2. Baglin I, Mitaine-Offer AC, Nour M, Tan K, Cavè C, Lacaille-Dubois MA. 2003. A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents. Mini Rev Med Chem 3: 525-539.
3. Barone I, Brusco L, Fuqua SA. 2010. Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res 16: 2702-2708.
4. Bonofiglio D, Cione E, Qi H, Pingitore A, Perri M, Catalano S, Vizza D, Panno ML, Genchi G, Fuqua SA, Andò S. 2009. Combined low doses of PPARgamma and RXR ligands trigger an intrinsic apoptotic pathway in human breast cancer cells. Am J Pathol 175: 1270-1280.
5. Catalano S, Giordano C, Rizza P, Gu G, Barone I, Bonofiglio D, Giordano F, Malivindi R, Gaccione D, Lanzino M, De Amicis F, Andò S. 2009. Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation. J Cell Physiol 218: 490-500.
6. Chung HS, Jeong HJ, Hong SH, Kim MS, Kim SJ, Song BK, Jeong IS, Lee EJ, Ahn JW, Baek SH, Kim HM. 2002. Induction of nitric oxide synthase by Oldenlandia diffusa in mouse peritoneal macrophages. Biol Pharm Bull 25: 1142-1146.
7. Cipak L, Grausova L, Miadokova E, Novotny L, Rauko P. 2006. Dual activity of triterpenoids: Apoptotic versus antidifferentiation effects. Arch Toxicol 80: 429-435.
8. Gupta S, Zhang D, Yi J, Shao J. 2004. Anticancer activities of Oldenlandia diffusa J Herb Pharmacother 4: 21-33.
9. Haupt S, Berger M, Goldberg Z, Haupt Y. 2003. Apoptosis-The p53 network. J Cell Sci 116: 4077-4085.
10. Herman ME, Katzenellenbogen BS. 1996. Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifen. J Steroid Biochem Mol Biol 59: 121-134.
11. Ikeda Y, Murakami A, Fujimura Y, Tachibana H, Yamada K, Masuda D, Hirano K, Yamashita S, Ohigashi H. 2007. Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: Role of CD36. J Immunol 178: 4854-4864.
12. Kassi E, Sourlingas TG, Spiliotaki M, Papoutsi Z, Pratsinis H, Aligiannis N, Moutsatsou P. 2009. Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells. Cancer Invest 27: 723-733.
13. Katzenellenbogen BS, Katzenellenbogen JA. 2000. Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: Regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2: 335-344.
14. Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI. 2003. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144: 1032-1044.
15. Krishnan V, Wang X, Safe S. 1994. Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells. J Biol Chem 269: 15912-15917.
16. Li J, Guo WJ, Yang QY. 2002. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World J Gastroenterol 8: 493-495.
17. Liang ZT, Jiang ZH, Leung KS, Zhao ZZ. 2006. Determination of iridoid glucosides for quality assessment of Herba oldenlandiae by high-performance liquid chromatography. Chem Pharm Bull (Tokyo) 54: 1131-1137.
18. Liu J. 1995. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49: 57-68.
19. Normanno N, Di Maio M, De Maio E, De Luca A, de Matteis A, Giordano A, Perrone F. 2005. Mechanisms of endocrine resistance and novel therapeutic strategies in breast cancer. Endocr Relat Cancer 12: 721-747.
20. Novotny L, Vachalkova A, Biggs D. 2001. Ursolic acid: An anti-tumorigenic and chemopreventive activity. Minireview. Neoplasma 48: 241-246.
21. Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'Ev A. 2002. Regulation of p53: Intricate loops and delicate balances. Ann N Y Acad Sci 973: 374-383.
22. Osborne CK, Schiff R. 2005. Estrogen-receptor biology: Continuing progress and therapeutic implications. J Clin Oncol 23: 1616-1622.
23. Ovesna Z, Vachalkova A, Horvathova K, Tothova D. 2004. Pentacyclic triterpenoic acids: New chemoprotective compounds. Minireview. Neoplasma 51: 327-333.
24. Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
25. Porter W, Saville B, Hoivik D, Safe S. 1997. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol 11: 1569-1580.
26. Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S. 2002. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Mol Endocrinol 16: 1793-1809.
27. Reddy L, Odhav B, Bhoola KD. 2003. Natural products for cancer prevention: A global perspective. Pharmacol Ther 99: 1-13.
28. Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. 2000. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol 18: 2505-2514.
29. Sadava D, Ahn J, Zhan M, Pang ML, Ding J, Kane SE. 2002. Effects of four Chinese herbal extracts on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. Cancer Chemother Pharmacol 49: 261-266.
30. Schuler M, Green DR. 2001. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29: 684-688.
31. Sengupta S, Wasylyk B. 2004. Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors. Ann N Y Acad Sci 1024: 54-71.
32. Sirianni R, Chimento A, Malivindi R, Mazzitelli I, Ando S, Pezzi V. 2007. Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation. Cancer Res 67: 8368-8377.
33. Sisci D, Middea E, Morelli C, Lanzino M, Aquila S, Rizza P, Catalano S, Casaburi I, Maggiolini M, Ando S. 2010. 17beta-estradiol enhances alpha(5) integrin subunit gene expression through ERalpha-Sp1 interaction and reduces cell motility and invasion of ERalpha-positive breast cancer cells. Breast Cancer Res Treat 124: 63-77.
34. Willimott S, Barker J, Jones LA, Opara EI. 2007. Apoptotic effect of Oldenlandia diffusa on the leukaemic cell line HL60 and human lymphocytes. J Ethnopharmacol 114: 290-299.
35. Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL. 2009. Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Life Sci 85: 113-121.
36. Yeh CT, Wu CH, Yen GC. 2010. Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. Mol Nutr Food Res 54: 1285-1295.
37. Yoshida Y, Wang MQ, Liu JN, Shan BE, Yamashita U. 1997. Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol 19: 359-370.
38. Yu J, Zhang L. 2005. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331: 851-858.