메뉴 건너뛰기




Volumn 4, Issue 4, 2012, Pages 458-467

A systematic approach to exosome-based translational nanomedicine

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; CANCER VACCINE; CLINICAL USE; CONFLICT OF INTEREST; CONFLICTS OF INTEREST; DEFORMABLE STRUCTURES; EXOSOMES; EXTRACELLULAR; IMMUNE MODULATION; NANOSCALE SIZE; NANOVESICLE; NATIVE CONFORMATION; PRINCIPAL INVESTIGATORS; RELAY INFORMATION; TUMOR METASTASIS;

EID: 84862659532     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1174     Document Type: Article
Times cited : (83)

References (62)
  • 2
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol 1983, 97:329-339.
    • (1983) J Cell Biol , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 3
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids.
    • Thery C, Clayton A, Amigorena S, Raposo G. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006, 3:221-229.
    • (2006) Curr Protoc Cell Biol , vol.3 , pp. 221-229
    • Thery, C.1    Clayton, A.2    Amigorena, S.3    Raposo, G.4
  • 5
    • 20744436655 scopus 로고    scopus 로고
    • Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins
    • Lancaster GI, Febbraio MA. Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem 2005, 280:23349-23355.
    • (2005) J Biol Chem , vol.280 , pp. 23349-23355
    • Lancaster, G.I.1    Febbraio, M.A.2
  • 6
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 7
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
    • Heijnen HF, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999, 94:3791-3799.
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 8
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
    • Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 2001, 166:7309-7318.
    • (2001) J Immunol , vol.166 , pp. 7309-7318
    • Thery, C.1    Boussac, M.2    Veron, P.3    Ricciardi-Castagnoli, P.4    Raposo, G.5    Garin, J.6    Amigorena, S.7
  • 9
    • 7244221520 scopus 로고    scopus 로고
    • Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro
    • Hristov M, Erl W, Linder S, Weber PC. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood 2004, 104:2761-2766.
    • (2004) Blood , vol.104 , pp. 2761-2766
    • Hristov, M.1    Erl, W.2    Linder, S.3    Weber, P.C.4
  • 10
    • 42749092828 scopus 로고    scopus 로고
    • Itinerant exosomes: emerging roles in cell and tissue polarity
    • Lakkaraju A, Rodriguez-Boulan E. Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol 2008, 18:199-209.
    • (2008) Trends Cell Biol , vol.18 , pp. 199-209
    • Lakkaraju, A.1    Rodriguez-Boulan, E.2
  • 12
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • Taylor DD, Gercel-Taylor C. Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer 2005, 92:305-311.
    • (2005) Br J Cancer , vol.92 , pp. 305-311
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 13
    • 0036178402 scopus 로고    scopus 로고
    • Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles
    • Oshima K, Aoki N, Kato T, Kitajima K, Matsuda T. Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. Eur J Biochem 2002, 269:1209-1218.
    • (2002) Eur J Biochem , vol.269 , pp. 1209-1218
    • Oshima, K.1    Aoki, N.2    Kato, T.3    Kitajima, K.4    Matsuda, T.5
  • 14
    • 70350681050 scopus 로고    scopus 로고
    • Paracrine induction of endothelium by tumor exosomes
    • Hood JL, Pan H, Lanza GM, Wickline SA. Paracrine induction of endothelium by tumor exosomes. Lab Invest 2009, 89:1317-1328.
    • (2009) Lab Invest , vol.89 , pp. 1317-1328
    • Hood, J.L.1    Pan, H.2    Lanza, G.M.3    Wickline, S.A.4
  • 19
    • 10644236207 scopus 로고    scopus 로고
    • Proteomic analysis fo melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry
    • Mears R, Craven RA, Hanrahan S, Totty N, Upton C, Young SL, Patel P, Selby PJ, Banks RE. Proteomic analysis fo melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics 2004, 4:4019-4031.
    • (2004) Proteomics , vol.4 , pp. 4019-4031
    • Mears, R.1    Craven, R.A.2    Hanrahan, S.3    Totty, N.4    Upton, C.5    Young, S.L.6    Patel, P.7    Selby, P.J.8    Banks, R.E.9
  • 20
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9:581-593.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 22
    • 79953202918 scopus 로고    scopus 로고
    • Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis
    • Rana S, Zoller M. Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis. Biochem Soc Trans 2011, 39:559-562.
    • (2011) Biochem Soc Trans , vol.39 , pp. 559-562
    • Rana, S.1    Zoller, M.2
  • 25
    • 0019874126 scopus 로고
    • Exfoliation of membrane ecto-enzymes in the form of micro-vesicles
    • Trams EG, Lauter CJ, Salem N Jr, Heine U. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta 1981, 645:63-70.
    • (1981) Biochim Biophys Acta , vol.645 , pp. 63-70
    • Trams, E.G.1    Lauter, C.J.2    Salem, N.3    Heine, U.4
  • 26
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).
    • Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem 1987, 262:9412-9420.
    • (1987) J Biol Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 27
    • 31144445302 scopus 로고    scopus 로고
    • Pregnancy-associated exosomes and their modulation of T cell signaling.
    • Taylor DD, Akyol S, Gercel-Taylor C. Pregnancy-associated exosomes and their modulation of T cell signaling. J Immunol 2006, 176:1534-1542.
    • (2006) J Immunol , vol.176 , pp. 1534-1542
    • Taylor, D.D.1    Akyol, S.2    Gercel-Taylor, C.3
  • 28
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnositic biomarkers of ovarian cancer.
    • Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnositic biomarkers of ovarian cancer. Gynecol Oncol 2008, 110:13-21.
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 29
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029.
    • Gesierich S, Berezovskiy I, Ryschich E, Zoller M. Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res 2006, 66: 7083-7094.
    • (2006) Cancer Res , vol.66 , pp. 7083-7094
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zoller, M.4
  • 30
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi K, Meehan B, Micallef J, Lhotak V, May L, Guha A, Rak J. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 2008, 10:619-624.
    • (2008) Nat Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 31
    • 79952261021 scopus 로고    scopus 로고
    • Exosomes and cancer: a newly described pathway of immune suppression
    • Zhang HG, Grizzle WE. Exosomes and cancer: a newly described pathway of immune suppression. Clin Cancer Res 2011, 17:959-964.
    • (2011) Clin Cancer Res , vol.17 , pp. 959-964
    • Zhang, H.G.1    Grizzle, W.E.2
  • 33
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood JL, San RS, Wickline SA. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res 2011, 71:3792-3801.
    • (2011) Cancer Res , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 34
    • 80054717963 scopus 로고    scopus 로고
    • Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts
    • Cho JA, Park H, Lim EH, Kim KH, Choi JS, Lee JH, Shin JW, Lee KW. Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol Oncol 2011, 123:379-386.
    • (2011) Gynecol Oncol , vol.123 , pp. 379-386
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Kim, K.H.4    Choi, J.S.5    Lee, J.H.6    Shin, J.W.7    Lee, K.W.8
  • 35
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived
    • Cho JA, Park H, Lim EH, Lee KW. Exosomes from breast cancer cells can convert adipose tissue-derived. Int J Oncol 2012, 40:130-138.
    • (2012) Int J Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 36
    • 79952115112 scopus 로고    scopus 로고
    • The application of exosomes as a nanoscale cancer vaccine
    • Tan A, De La Pena H, Seifalian AM. The application of exosomes as a nanoscale cancer vaccine. Int J Nanomed 2010, 5:889-900.
    • (2010) Int J Nanomed , vol.5 , pp. 889-900
    • Tan, A.1    De La Pena, H.2    Seifalian, A.M.3
  • 39
    • 79551475841 scopus 로고    scopus 로고
    • Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery
    • Raimondo F, Morosi L, Chinello C, Magni F, Pitto M. Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery. Proteomics 2011, 11:709-720.
    • (2011) Proteomics , vol.11 , pp. 709-720
    • Raimondo, F.1    Morosi, L.2    Chinello, C.3    Magni, F.4    Pitto, M.5
  • 40
    • 1542328938 scopus 로고    scopus 로고
    • Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics
    • El-Hefnawy T, Raja S, Kelly L, Bigbee WL, Kirkwood JM, Luketich JD, Godfrey TE. Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem 2004, 50:564-573.
    • (2004) Clin Chem , vol.50 , pp. 564-573
    • El-Hefnawy, T.1    Raja, S.2    Kelly, L.3    Bigbee, W.L.4    Kirkwood, J.M.5    Luketich, J.D.6    Godfrey, T.E.7
  • 42
    • 79959330841 scopus 로고    scopus 로고
    • Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
    • Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces 2011, 87:146-150.
    • (2011) Colloids Surf B Biointerfaces , vol.87 , pp. 146-150
    • Sokolova, V.1    Ludwig, A.K.2    Hornung, S.3    Rotan, O.4    Horn, P.A.5    Epple, M.6    Giebel, B.7
  • 44
    • 0033567094 scopus 로고    scopus 로고
    • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor
    • Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, Yuan F, Jain RK. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res 1999, 59:4129-4135.
    • (1999) Cancer Res , vol.59 , pp. 4129-4135
    • Monsky, W.L.1    Fukumura, D.2    Gohongi, T.3    Ancukiewcz, M.4    Weich, H.A.5    Torchilin, V.P.6    Yuan, F.7    Jain, R.K.8
  • 45
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers' entry into the cell: relevance to drug delivery
    • Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009, 66:2873-2896.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 47
  • 49
    • 79953078280 scopus 로고    scopus 로고
    • Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells
    • Atay S, Gercel-Taylor C, Kesimer M, Taylor DD. Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells. Exp Cell Res 2011, 317:1192-1202.
    • (2011) Exp Cell Res , vol.317 , pp. 1192-1202
    • Atay, S.1    Gercel-Taylor, C.2    Kesimer, M.3    Taylor, D.D.4
  • 50
    • 0035726161 scopus 로고    scopus 로고
    • Is the cell a gel-and why does it matter?
    • Pollack GH. Is the cell a gel-and why does it matter? Jpn J Physiol 2001, 51:649-660.
    • (2001) Jpn J Physiol , vol.51 , pp. 649-660
    • Pollack, G.H.1
  • 54
    • 84862659460 scopus 로고    scopus 로고
    • Detection and analysis of nanoscale tumor membrane biomarkers
    • Hood JL, Pan H, Eby CS, Wickline SA. Detection and analysis of nanoscale tumor membrane biomarkers. Am J Clin Pathol 2009, 132:460-461.
    • (2009) Am J Clin Pathol , vol.132 , pp. 460-461
    • Hood, J.L.1    Pan, H.2    Eby, C.S.3    Wickline, S.A.4
  • 55
    • 77953760056 scopus 로고    scopus 로고
    • Antibody-mediated modulation of immune responses
    • Nimmerjahn F, Ravetch JV. Antibody-mediated modulation of immune responses. Immunol Rev 2010, 236:265-275.
    • (2010) Immunol Rev , vol.236 , pp. 265-275
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 56
    • 84873214884 scopus 로고    scopus 로고
    • ® Handbook. A guide to fluorescent probes and labeling technologies. Available at: (Accessed February 13, 2012)
    • ® Handbook. A guide to fluorescent probes and labeling technologies. Available at: http://www.invitrogen.com/site/us/en/home/Molecular-Probes-The-Handbook/Fluorescent-Tracers-of-Cell-Morphology-and-Fluid-Flow/Tracers-for-Membrane-Labeling.html#head1. (Accessed February 13, 2012)
  • 57
    • 77955891615 scopus 로고    scopus 로고
    • "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking
    • Lassailly F, Griessinger E, Bonnet D. "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking. Blood 2010, 115:5347-5354.
    • (2010) Blood , vol.115 , pp. 5347-5354
    • Lassailly, F.1    Griessinger, E.2    Bonnet, D.3
  • 58
    • 23844460881 scopus 로고    scopus 로고
    • Three-dimensional tissue culture models in cancer biology
    • Bin KJ. Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol 2005, 15:365-377.
    • (2005) Semin Cancer Biol , vol.15 , pp. 365-377
    • Bin, K.J.1
  • 60
    • 34547931078 scopus 로고    scopus 로고
    • Modeling tissue morphogenesis and cancer in 3D
    • Yamada KM, Cukierman E. Modeling tissue morphogenesis and cancer in 3D. Cell 2007, 130:601-610.
    • (2007) Cell , vol.130 , pp. 601-610
    • Yamada, K.M.1    Cukierman, E.2
  • 61
    • 80052831943 scopus 로고    scopus 로고
    • Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers
    • Lakhal S, Wood MJ. Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers. BioEssays 2011, 33:737-741.
    • (2011) BioEssays , vol.33 , pp. 737-741
    • Lakhal, S.1    Wood, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.