Endothelial lipase: A modulator of lipoprotein metabolism upregulated by inflammation

Trends in Cardiovascular Medicine

Volumn 14, Issue 5, 2004, Pages 202-206

  Broedl, Uli C ^a   Jin, Weijun ^a   Rader, Daniel J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ATHEROSCLEROSIS; CYTOKINE PRODUCTION; ENDOTHELIUM; ENDOTHELIUM CELL; ENERGY METABOLISM; ENZYME METABOLISM; GENETIC VARIABILITY; HOMEOSTASIS; HUMAN; IN VITRO STUDY; INFLAMMATION; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; UPREGULATION;

HUMANS; INFLAMMATION; LIPASE; LIPOPROTEINS;

EID: 3242689803     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcm.2004.03.003     Document Type: Review

References (45)

1. Aitman TJ, Glazier AM, Wallace CA, et al.: 1999. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21:76-83.
2. Azumi H, Hirata K, Ishida T, et al.: 2003. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res 58:647-654.
3. Babaev VR, Fazio S, Gleaves LA, et al.: 1999. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J Clin Invest 103:1697-1705.
4. Blades B, Vega GL, Grundy SM: 1993. Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol. Arterioscler Thromb 13:1227-1235.
5. Broedl UC, Maugeais C, Marchadier D, et al.: 2003. Effects of nonlipolytic ligand function of endothelial lipase on HDL metabolism in vivo. J Biol Chem 278:40,688-40,693.
6. Cabana VG, Siegel JN, Sabesin SM: 1989. Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. J Lipid Res 30:39-49.
7. deLemos AS, Wolfe ML, Long CJ, et al.: 2002. Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation 106:1321-1326.
8. Febbraio M, Abumrad NA, Hajjar DP, et al.: 1999. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274:19,055-19,062.
9. Feingold KR, Staprans I, Memon RA: 1992. Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 33:1765-1776.
10. Feingold KR, Memon RA, Moser AH, et al.: 1999. Endotoxin and interleukin-1 decrease hepatic lipase mRNA levels. Atherosclerosis 142:379-387.
11. Fournier N, Paul JL, Atger V, et al.: 1997. HDL phospholipid content and composition as a major factor determining cholesterol efflux capacity from Fu5AH cells to human serum. Arterioscler Thromb Vasc Biol 17:2685-2691.
12. Fuki IV, Blanchard N, Jin W, et al.: 2003. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via HSPG-mediated pathway. J Biol Chem 278:34,331-34,338.
13. Gijon MA, Leslie CC: 1997. Phospholipases A2. Semin Cell Dev Biol 8:297-303.
14. Goldberg IJ: 1996. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 37:693-707.
15. Gouni I, Oka K, Etienne J, et al.: 1993. Endotoxin-induced hypertriglyceridemia is mediated by suppression of lipoprotein lipase at a post-transcriptional level. J Lipid Res 34:139-146.
16. Hardardottir I, Grunfeld C, Feingold KR: 1994. Effects of endotoxin and cytokines on lipid metabolism. Curr Opin Lipidol 5:207-215.
17. Hirata K, Dichek HL, Cioffi JA, et al.: 1999. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 274:14,170-14,175.
18. Hirata K, Ishida T, Matsushita H, et al.: 2000. Regulated expression of endothelial cellderived lipase. Biochem Biophys Res Commun 272:90-93.
19. Homcy CJ, Liberthson RR, Fallon JT, et al.: 1982. Ischemic heart disease in systemic lupus erythematosus in the young patient: report of six cases. Am J Cardiol 49:478-484.
20. Ishida T, Choi S, Kundu RK, et al.: 2003. Endothelial lipase is a major determinant of HDL level. J Clin Invest 111:347-355.
21. Jaye M, Lynch KJ, Krawiec J, et al.: 1999. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 21:424-428.
22. Ji ZS, Lauer SJ, Fazio S, et al.: 1994. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J Biol Chem 269:13,429-13,436.
23. Jin W, Millar JS, Broedl U, et al.: 2003a. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest 111:357-362.
24. Jin W, Sun GS, Marchadier D, et al.: 2003b. Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 92:644-650.
25. Kume N, Cybulsky MI, Gimbrone, MA Jr: 1992. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest 90:1138-1144.
26. Laine VJ, Grass DS, Nevalainen TJ: 1999. Protection by group II phospholipase A2 against Staphylococcus aureus. J Immunol 162:7402-7408.
27. Laine VJ, Grass DS, Nevalainen TJ: 2000. Resistance of transgenic mice expressing human group II phospholipase A2 to Escherichia coli infection. Infect Immun 68:87-92.
28. Lee RT, Libby P: 1997. The unstable atheroma. Arterioscler Thromb Vasc Biol 17:1859-1867.
29. Ma K, Cilingiroglu M, Otvos JD, et al.: 2003. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci USA 100:2748-2753.
30. Mangin EL Jr, Kugiyama K, Nguy JH, et al.: 1993. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ Res 72:161-166.
31. McCoy MG, Sun GS, Marchadier D, et al.: 2002. Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 43:921-929.
32. Olivecrona G, Olivecrona T: 1995. Triglyceride lipases and atherosclerosis. Curr Opin Lipidol 6:291-305.
33. Paradis ME, Couture P, Bosse Y, et al.: 2003. The T111I missense mutation of the endothelial lipase gene modulates the relationship between dietary fat intake and the HDL profile in women. J Lipid Res 44:1902-1908.
34. Querfeld U, Ong JM, Prehn J, et al.: 1990. Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages. J Lipid Res 31:1379-1386.
35. Rader DJ: 2000. Inflammatory markers of coronary risk. N Engl J Med 343:1179-1182.
36. Reilly PA, Cosh JA, Maddison PJ, et al.: 1990. Mortality and survival in rheumatoid arthritis: a 25 year prospective study of 100 patients. Ann Rheum Dis 49:363-369.
37. Ridker PM, Buring JE, Shih J, et al.: 1998. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation 98:731-733.
38. Ross R: 1999. Atherosclerosis - an inflammatory disease. N Engl J Med 340:115-126.
39. Santamarina-Fojo S, Haudenschild C, Amar M: 1998. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 9:211-219.
40. Shimada M, Ishibashi S, Inaba T, et al.: 1996. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci USA 93:7242-7246.
41. Stiko A, Regnstrom J, Shah PK, et al.: 1996. Active oxygen species and lysophosphatidylcholine are involved in oxidized low density lipoprotein activation of smooth muscle cell DNA synthesis. Arterioscler Thromb Vasc Biol 16:194-200.
42. Tietge UJ, Maugeais C, Lund-Katz S, et al.: 2002. Human secretory phospholipase A2 mediates decreased plasma levels of HDL cholesterol and apoA-I in response to inflammation in human apoA-I transgenic mice. Arterioscler Thromb Vasc Biol. 22:1213-1218.
43. Tietge UJ, Maugeais C, Cain W, et al.: 2003. Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2. Am J Physiol Endocrinol Metab 285:E403-E411.
44. Yagyu H, Ishibashi S, Chen Z: 1999. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 40:1877-1885.
45. Yamakawa-Kobayashi K, Yanagi H, Fukayama H, et al.: 2003. Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children. Hum Genet 113:311-315.