Excessively high soluble Klotho in patients with acromegaly

Journal of Internal Medicine

Volumn 272, Issue 1, 2012, Pages 93-97

  Sze, L ^a,b   Bernays, R L ^a   Zwimpfer, C ^a   Wiesli, P ^c   Brandle M ^b   Schmid, C ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b KANTONSSPITAL   (Switzerland)

^c Kantonsspital Frauenfeld ^*  (Switzerland)

Author keywords

Acromegaly; Growth hormone; Kidney; Klotho; Phosphate

Indexed keywords

CREATININE; GLUCOSE; GROWTH HORMONE; KLOTHO PROTEIN; PHOSPHATE; SOMATOMEDIN C;

ACROMEGALY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; KIDNEY FUNCTION; LIFE EXPECTANCY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRANSSPHENOIDAL SURGERY;

ACROMEGALY; ADULT; AGED; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PITUITARY NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84862646695     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2012.02542.x     Document Type: Article

References (25)

1. Kuro-o M, Matsumura Y, Aizawa H et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390: 45-51.
2. Arking DE, Krebsova A, Macek M Sr et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 2002; 99: 856-61.
3. Ichikawa S, Imel EA, Kreiter ML et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest 2007; 117: 2684-91.
4. Koh N, Fujimori T, Nishiguchi S et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun 2001; 280: 1015-20.
5. Kurosu H, Ogawa Y, Miyoshi M et al. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 2006; 281: 6120-3.
6. Urakawa I, Yamazaki Y, Shimada T et al. Regulation of fibroblast growth factor-23 signaling by klotho. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 2006; 444: 770-4.
7. Kuro-o M. Klotho and aging. Biochim Biophys Acta 2009; 1790: 1049-58.
8. Imura A, Tsuji Y, Murata M et al. alpha-Klotho as a regulator of calcium homeostasis. Science 2007; 316: 1615-18.
9. Yamazaki Y, Imura A, Urakawa I et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun 2010; 398: 513-18.
10. Semba RD, Cappola AR, Sun K et al. Plasma Klotho and Cardiovascular Disease in Adults. J Am Geriatr Soc 2011; 59: 1596-601.
11. Semba RD, Cappola AR, Sun K et al. Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci 2011; 66: 794-800.
12. Corvilain J, Abramow M, Bergans A. Some effects of human growth hormone on renal hemodynamics and on tubular phosphate transport in man. J Clin Invest 1962; 41: 1230-5.
13. Lund B, Eskildsen PC, Lund B, Norman AW, Sørensen OH. Calcium and vitamin D metabolism in acromegaly. Acta Endocrinol (Copenh) 1981; 96: 444-50.
14. Takamoto S, Tsuchiya H, Onishi T et al. Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy. J Clin Endocrinol Metab 1985; 61: 7-11.
15. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G, Cholesterol and Recurrent Events Trial Investigators. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005; 112: 2627-33.
16. Foley RN. Phosphate levels and cardiovascular disease in the general population. Clin Am Soc Nephrol 2009; 4: 1136-9.
17. Bellut D, Hlavica M, Schmid C, Bernays RL. Intraoperative magnetic resonance imaging-assisted transsphenoidal pituitary surgery in patients with acromegaly. Neurosurg Focus 2010; 29: E9.
18. Sze L, Schmid C, Bloch KE, Bernays R, Brändle M. Effect of transsphenoidal surgery on sleep apnoea in acromegaly. Eur J Endocrinol 2007; 156: 321-9.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-19.
20. Levey AS, Stevens LA, Schmid CH et al. CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-12.
21. Ito N, Fukumoto S, Taguchi M et al. Fibroblast growth factor (FGF)23 in patients with acromegaly. Endocr J 2007; 54: 481-4.
22. Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 1998; 242: 626-30.
23. Bloch L, Sineshchekova O, Reichenbach D et al. Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett 2009; 583: 3221-4.
24. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA 2007; 104: 19796-801.
25. Berryman DE, Christiansen JS, Johannsson G, Thorner MO, Kopchick JJ. Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models. Growth Horm IGF Res 2008; 18: 455-71.