Synthesis of two new alkyne-bearing linkers used for the preparation of siRNA for labeling by click chemistry with fluorine-18

Applied Radiation and Isotopes

Volumn 70, Issue 8, 2012, Pages 1549-1557

  Flagothier, Jessica ^a   Kaisin, Geoffroy ^a   Mercier, Frederic ^a   Thonon, David ^a   Teller, Nathalie ^b   Wouters, Johan ^c   Luxen, André ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b EUROGENTEC S A   (Belgium)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Click chemistry; Fluorine 18; PET; Radiochemistry; SiRNA

Indexed keywords

BIODISTRIBUTIONS; BIOLOGICAL PROCESS; CLICK CHEMISTRY; FLUORINE-18; HUISGEN CYCLOADDITION; IN-VIVO; PROSTHETIC GROUPS; RADIOCHEMISTRY; SIRNA;

ACETYLENE; FLUORINE; OLIGONUCLEOTIDES; PHARMACOKINETICS; POLYETHYLENE TEREPHTHALATES; POSITRON EMISSION TOMOGRAPHY;

SYNTHESIS (CHEMICAL);

FLUORINE 18; OLIGONUCLEOTIDE; SMALL INTERFERING RNA;

ACYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CLICK CHEMISTRY; CYCLOADDITION; DEGRADATION; ENANTIOMER; ESTERIFICATION; HUISGEN CYCLOADDITION; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOCHEMISTRY; STEREOCHEMISTRY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ALKYNES; FLUORINE RADIOISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84862629483     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.04.022     Document Type: Article

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