Nrf2-Mediated Resistance to Oxidant-Induced Redox Disruption in Embryos

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 95, Issue 3, 2012, Pages 213-218

  Harris, Craig ^a   Hansen, Jason M ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Embryo; Glutathione; Nrf2; Redox; Thioredoxin

Indexed keywords

ANTIOXIDANT; DITHIOLE 3 THIONE; GLUTATHIONE; HYDROGEN PEROXIDE; THIOPHENE; THIOREDOXIN 1; THIOREDOXIN 2; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; GESTATION PERIOD; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; TERATOGENESIS; TRANSCRIPTION INITIATION;

ANIMALS; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE; HYDROGEN PEROXIDE; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; OXIDANTS; OXIDATION-REDUCTION; THIONES; THIOPHENES; THIOREDOXINS;

EID: 84862597106     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21005     Document Type: Article

References (38)

1. Abate C, Patel L, Rauscher FJ, 3rd, Curran T. 1990. Redox regulation of fos and jun DNA-binding activity in vitro. Science 249(4973):1157-1161.
2. Akella SS, Beck MJ, Philbert MA, Harris C. 2000. Comparison of in vitro and in utero ethanol exposure on indices of oxidative stress. In Vitro Mol Toxicol 13(4):281-296.
3. Allen RG, Balin AK. 1989. Oxidative influence on development and differentiation: an overview of a free radical theory of development. Free Radic Biol Med 6(6):631-661.
4. Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, Janssen-Heininger Y. 2011. Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death. Antioxid Redox Signal 16:496-505.
5. Chen Y, Cai J, Murphy TJ, Jones DP. 2002. Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. J Biol Chem 277(36):33242-33248.
6. Dong J, Sulik KK, Chen SY. 2008. Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders. Antioxid Redox Signal 10(12):2023-2033.
7. Halvey PJ, Watson WH, Hansen JM, Go YM, Samali A, Jones DP. 2005. Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling. Biochem J 386(Pt 2):215-219.
8. Hansen JM. 2006. Oxidative stress as a mechanism of teratogenesis. Birth Defects Res C Embryo Today 78(4):293-307.
9. Hansen JM, Harris C. 2004. A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway. Antioxid Redox Signal 6(1):1-14.
10. Hansen JM, Harris KK, Philbert MA, Harris C. 2002. Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb. J Pharmacol Exp Ther 300(3):768-776.
11. Hansen JM, Zhang H, Jones DP. 2006. Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions. Free Radic Biol Med 40(1):138-145.
12. He M, Cai J, Go YM, Johnson JM, Martin WD, Hansen JM, Jones DP. 2008. Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition. Toxicol Sci 105(1):44-50.
13. Henderson GI, Chen JJ, Schenker S. 1999. Ethanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci 4:D541-D550.
14. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J. 1997. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci USA 94(8):3633-3638.
15. Hitchler MJ, Domann FE. 2007. An epigenetic perspective on the free radical theory of development. Free Radic Biol Med 43(7):1023-1036.
16. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C. 1997. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 11(5):558-570.
17. Jones DP. 2002. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol 348:93-112.
18. Jones DP, Mody VC, Jr, Carlson JL, Lynn MJ, Sternberg P, Jr. 2002. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic Biol Med 33(9):1290-1300.
19. Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ, Jones DP. 1999. Glutathione redox potential in response to differentiation and enzyme inducers. Free Radic Biol Med 27(11-12):1208-1218.
20. Kwak MK, Itoh K, Yamamoto M, Kensler TW. 2002. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the Nrf2 promoter. Mol Cell Biol 22(9):2883-2892.
21. Kwak MK, Itoh K, Yamamoto M, Sutter TR, Kensler TW. 2001. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione. Mol Med 7(2):135-145.
22. Long L, Li Y, Wang YD, He QY, Li M, Cai XD, Peng K, Li XP, Xie D, Wen YL, Yin de L, Peng Y. 2010. The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model. Alcohol Clin Exp Res 34(11):1929-1936.
23. Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT. 1992. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res 20(15):3821-3830.
24. Mitomo K, Nakayama K, Fujimoto K, Sun X, Seki S, Yamamoto K. 1994. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro. Gene 145(2):197-203.
25. Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Aizawa S, Tanaka H, Kataoka K, Watanabe H, Handa H. 2002. Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem 277(46):44548-44556.
26. Ornaghi F, Ferrini S, Prati M, Giavini E. 1993. The protective effects of N-acetyl-L-cysteine against methyl mercury embryotoxicity in mice. Fundam Appl Toxicol 20(4):437-445.
27. Ozolins TR, Hales BF. 1997. Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus. J Pharmacol Exp Ther 280(2):1085-1093.
28. Ozolins TR, Harrouk W, Doerksen T, Trasler JM, Hales BF. 2002. Buthionine sulfoximine embryotoxicity is associated with prolonged AP-1 activation. Teratology 66(4):192-200.
29. Parman T, Wiley MJ, Wells PG. 1999. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat Med 5(5):582-585.
30. Parnell SE, Sulik KK, Dehart DB, Chen SY. 2010. Reduction of ethanol-induced ocular abnormalities in mice through dietary administration of N-acetylcysteine. Alcohol 44(7-8):699-705.
31. Ranganna K, Mathew OP, Yatsu FM, Yousefipour Z, Hayes BE, Milton SG. 2007. Involvement of glutathione/glutathione S-transferase antioxidant system in butyrate-inhibited vascular smooth muscle cell proliferation. FEBS J 274(22):5962-5978.
32. Sadler TW. 1979. Culture of early somite mouse embryos during organogenesis. J Embryol Exp Morphol 49:17-25.
33. Sauer H, Gunther J, Hescheler J, Wartenberg M. 2000. Thalidomide inhibits angiogenesis in embryoid bodies by the generation of hydroxyl radicals. Am J Pathol 156(1):151-158.
34. Seki S, Ikeda S, Watanabe S, Hatsushika M, Tsutsui K, Akiyama K, Zhang B. 1991. A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization. Biochim Biophys Acta 1079(1):57-64.
35. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S. 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62(18):5196-5203.
36. Xanthoudakis S, Curran T. 1996. Redox regulation of AP-1: a link between transcription factor signaling and DNA repair. Adv Exp Med Biol 387:69-75.
37. Yan D, Dong J, Sulik KK, Chen SY. 2010. Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. Biochem Pharmacol 80(1):144-149.
38. Yan Y, Sabharwal P, Rao M, Sockanathan S. 2009. The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2. Cell 138(6):1209-1221.