Recent progress in computational approaches to studying the M2 proton channel and its implication to drug design against influenza viruses

Current Protein and Peptide Science

Volumn 13, Issue 3, 2012, Pages 205-210

  Du, Qi Shi ^a,b   Huang, Ri Bo ^a,b  

^a NATIONAL ENGINEERING RESEARCH CENTER FOR NON FOOD BIOREFINERY   (China)

^b GUANGXI UNIVERSITY   (China)

Author keywords

Allosteric inhibition mechanism; Amantadine; Influenza a virus; M2 proton channel; PKa shift; Rational drug design; Rimantadine

Indexed keywords

AMANTADINE; ANTIINFLUENZA VIRUS AGENT; ANTIVIRUS AGENT; PROTEIN M2; RIMANTADINE; UNCLASSIFIED DRUG;

ALLOSTERISM; CHANNEL GATING; DRUG BINDING; DRUG DESIGN; HUMAN; INFLUENZA A; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VIRAL MATRIX PROTEINS;

EID: 84862585703     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/138920312800785030     Document Type: Review

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