Solution structure and functional analysis of the influenza B proton channel

Nature Structural and Molecular Biology

Volumn 16, Issue 12, 2009, Pages 1267-1271

  Wang, Junfeng ^a   Pielak, Rafal M ^a   McClintock, Mark A ^a   Chou, James J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; MATRIX PROTEIN; MATRIX PROTEIN M1; MEMBRANE PROTEIN; MEMBRANE PROTEIN BM2; PROTON; TETRAMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURFACE; CHANNEL GATING; COILED BODY; CONTROLLED STUDY; CYTOPLASM; ELECTRIC POTENTIAL; ESCHERICHIA COLI; GENOME; INFLUENZA VIRUS B; ION CONDUCTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTON TRANSPORT; VIRION; VIRUS LOAD;

INFLUENZA B VIRUS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTONS; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

INFLUENZA B VIRUS;

EID: 71449091133     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1707     Document Type: Article

References (30)

1. Hatta, M., Goto, H. & Kawaoka, Y. Infuenza B virus requires BM2 protein for replication. J. Virol. 78, 5576-5583 (2004).
2. Pinto, L.H. & Lamb, R.A. The M2 proton channels of infuenza A and B viruses. J. Biol. Chem. 281, 8997-9000 (2006).
3. Hay, A.J., Wolstenholme, A.J., Skehel, J.J. & Smith, M.H. The molecular basis of the specifc anti-infuenza action of amantadine. EMBO J. 4, 3021-3024 (1985).
4. Helenius, A. Unpacking the incoming infuenza virus. Cell 69, 577-578 (1992).
5. Paterson, R.G., Takeda, M., Ohigashi, Y., Pinto, L.H. & Lamb, R.A. Infuenza B virus BM2 protein is an oligomeric integral membrane protein expressed at the cell surface. Virology 306, 7-17 (2003).
6. Mould, J.A. et al. Infuenza B virus BM2 protein has ion channel activity that conducts protons across membranes. Dev. Cell 5, 175-184 (2003).
7. Pinto, L.H. et al. A functionally defned model for the M2 proton channel of infuenza A virus suggests a mechanism for its ion selectivity. Proc. Natl. Acad. Sci. USA 94, 11301-11306 (1997).
8. Kovacs, F.A., Denny, J.K., Song, Z., Quine, J.R. & Cross, T.A. Helix tilt of the M2 transmembrane peptide from infuenza A virus: an intrinsic property. J. Mol. Biol. 295, 117-125 (2000).
9. Kukol, A., Adams, P.D., Rice, L.M., Brunger, A.T. & Arkin, T.I. Experimentally based orientational refnement of membrane protein models: A structure for the infuenza A M2 H+ channel. J. Mol. Biol. 286, 951-962 (1999).
10. Schnell, J.R. & Chou, J.J. Structure and mechanism of the M2 proton channel of infuenza A virus. Nature 451, 591-595 (2008).
11. Wang, J., Kim, S., Kovacs, F. & Cross, T.A. Structure of the transmembrane region of the M2 protein H+ channel. Protein Sci. 10, 2241-2250 (2001).
12. Stouffer, A.L. et al. Structural basis for the function and inhibition of an infuenza virus proton channel. Nature 451, 596-599 (2008).
13. Ma, C. et al. Identifcation of the pore-lining residues of the BM2 ion channel protein of infuenza B virus. J. Biol. Chem. 283, 15921-15931 (2008).
14. Chen, B.J., Leser, G.P., Jackson, D. & Lamb, R.A. The infuenza virus M2 protein cytoplasmic tail interacts with the M1 protein and infuences virus assembly at the site of virus budding. J. Virol. 82, 10059-10070 (2008).
15. McCown, M.F. & Pekosz, A. Distinct domains of the infuenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J. Virol. 80, 8178-8189 (2006).
16. Imai, M., Kawasaki, K. & Odagiri, T. Cytoplasmic domain of infuenza B virus BM2 protein plays critical roles in production of infectious virus. J. Virol. 82, 728-739 (2008).
17. Imai, M., Watanabe, S., Ninomiya, A., Obuchi, M. & Odagiri, T. Infuenza B virus BM2 protein is a crucial component for incorporation of viral ribonucleoprotein complex into virions during virus assembly. J. Virol. 78, 11007-11015 (2004).
18. Pielak, R.M., Schnell, J.R. & Chou, J.J. Mechanism of drug inhibition and drug resistance of infuenza A M2 channel. Proc. Natl. Acad. Sci. USA 106, 7379-7384 (2009).
19. Xu, C. et al. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 135, 702-713 (2008).
20. Harbury, P.B., Zhang, T., Kim, P.S. & Alber, T. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science 262, 1401-1407 (1993). (Pubitemid 23983059)
21. Felder, C., Prilusky, J., Silman, I. & Sussman, J. A server and database for dipole moments of proteins. Nucleic Acids Res. 35 (special Web Servers Issue) (2007).
22. Sha, B. & Luo, M. Structure of a bifunctional membrane-RNA binding protein, infuenza virus matrix protein M1. Nat. Struct. Biol. 4, 239-244 (1997).
23. Otomo, K., Toyama, A., Miura, T. & Takeuchi, H. Interactions between histidine and tryptophan residues in the BM2 proton channel from infuenza B virus. J. Biochem. 145, 543-554 (2009).
24. Du, Q.S., Huang, R.B., Wang, C.H., Li, X.M. & Chou, K.C. Energetic analysis of the two controversial drug binding sites of the M2 proton channel in infuenza A virus. J. Theor. Biol. 259, 159-164 (2009).
25. Chou, J.J., Matsuo, H., Duan, H. & Wagner, G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94, 171-180 (1998).
26. Smart, O.S., Goodfellow, J.M. & Wallace, B.A. The pore dimensions of gramicidin A. Biophys. J. 65, 2455-2460 (1993).
27. Bax, A. et al. Measurement of homo-and heteronuclear J couplings from quantitative J correlation. Methods Enzymol. 239, 79-105 (1994).
28. Lorieau, J., Yao, L. & Bax, A. Liquid crystalline phase of G-tetrad DNA for NMR study of detergent-solubilized proteins. J. Am. Chem. Soc. 130, 7536-7537 (2008).
29. Schwieters, C.D., Kuszewski, J., Tjandra, N. & Clore, G.M. The Xplor-NIH NMR molecular structure determination package. J. Magn. Reson. 160, 66-74 (2002).
30. Cornilescu, G., Delaglio, F. & Bax, A. Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J. Biomol. NMR 13, 289-302 (1999).