In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution

Cancer Research

Volumn 72, Issue 12, 2012, Pages 2949-2956

  Earley, Sarah ^a   Vinegoni, Claudio ^a   Dunham, Joshua ^a   Gorbatov, Rostic ^a   Feruglio, Paolo Fumene ^a   Weissleder, Ralph ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCETAXEL; ERLOTINIB; GEMCITABINE; IMS REPORTER PROTEIN; MITOCHONDRIAL PROTEIN; NAVITOCLAX; PACLITAXEL; PROTEIN BCL 2; PROTEIN BCL W; PROTEIN BCL XL; RITUXIMAB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PERMEABILIZATION; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE; MOLECULAR IMAGING; MOUSE; NONHUMAN; OUTER MEMBRANE; PANCREAS CANCER; PRIORITY JOURNAL; SINGLE DRUG DOSE; TREATMENT RESPONSE;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, NUDE; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MOLECULAR IMAGING; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; SINGLE-CELL ANALYSIS; SULFONAMIDES; TUMOR MICROENVIRONMENT;

EID: 84862567978     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-4096     Document Type: Article

References (36)

1. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res 2011;71:4608-16.
2. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell 2008;30:11-25. (Pubitemid 351470145)
3. Nicholls SB, Chu J, Abbruzzese G, Tremblay KD, Hardy JA. Mechanism of a genetically encoded dark-to-bright reporter for caspase activity. J Biol Chem 2011;286:24977-86.
4. Loewer A, Batchelor E, Gaglia G, Lahav G. Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell 2010;142:89-100.
5. Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, et al. In vivo imaging of autophagy in a mouse stroke model. Autophagy 2010;6:1107-14.
6. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A 2004;101:12294-9. (Pubitemid 39145437)
7. Blankenberg FG, Vanderheyden JL, Strauss HW, Tait JF. Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis. Nat Protoc 2006;1:108-10.
8. Zhao M, Beauregard DA, Loizou L, Davletov B, Brindle KM. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 2001;7:1241-4. (Pubitemid 33063780)
9. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33-42.
10. Dabov K, Foi A, Katkovnik V, Egiazarian K. Image denoising by sparse 3-D transform-domain collaborative filtering. IEEE Trans Image Process 2007;16:2080-95. (Pubitemid 47225460)
11. Reis Y, Bernardo-Faura M, Richter D, Wolf T, Brors B, Hamacher-Brady A, et al. Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis. PLoS One 2012;7:e28694.
12. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 2009;459:428-32.
13. Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008;68:3421-8.
14. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005;435:677-81. (Pubitemid 40825512)
15. Park CM, Bruncko M, Adickes J, Bauch J, Ding H, Kunzer A, et al. Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. J Med Chem 2008;51:6902-15.
16. Shoemaker AR, Mitten MJ, Adickes J, Ackler S, Refici M, Ferguson D, et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin Cancer Res 2008;14:3268-77.
17. Pittet MJ, Weissleder R. Intravital imaging. Cell 2011;147:983-91.
18. Reiner T, Earley S, Turetsky A, Weissleder R. Bioorthogonal small-molecule ligands for PARP1 imaging in living cells. Chembiochem 2010;11:2374-7.
19. Budin G, Yang KS, Reiner T, Weissleder R. Bioorthogonal probes for Polo-like Kinase 1 imaging and quantification. Angew Chem Int Ed Engl 2011;50:9378-81.
20. Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 2010;465:1079-83.
21. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, et al. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 2008;9:282-91. (Pubitemid 351267325)
22. Celli S, Albert ML, Bousso P. Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy. Nat Med 2011;17:744-9.
23. Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, et al. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med 2009;15:1219-23.
24. Entenberg D, Wyckoff J, Gligorijevic B, Roussos ET, Verkhusha VV, Pollard JW, et al. Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc 2011;6:1500-20.
25. Roussos ET, Condeelis JS, Patsialou A.Chemotaxis in cancer. Nat Rev Cancer 2011;11:573-87.
26. Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009;10:445-57.
27. Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R. Novel multiwavelength microscopic scanner for mouse imaging. Neoplasia 2005;7:977-83.
28. Barretto RP, Ko TH, Jung JC, Wang TJ, Capps G, Waters AC, et al. Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy. Nat Med 2011;17:223-8.
29. Filonov GS, Piatkevich KD, Ting LM, Zhang J, Kim K, Verkhusha VV. Bright and stable near-infrared fluorescent protein for in vivo imaging. Nat Biotechnol 2011;29:757-61.
30. Jaqaman K, King EM, Amaro AC, Winter JR, Dorn JF, Elliott HL, et al. Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. J Cell Biol 2010;188:665-79.
31. Thoma CR, Matov A, Gutbrodt KL, Hoerner CR, Smole Z, Krek W, et al. Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability. J Cell Biol 2010;190:991-1003.
32. Jaqaman K, Loerke D, Mettlen M, Kuwata H, Grinstein S, Schmid SL, et al. Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods 2008;5:695-702.
33. Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol 2009;20:54-62.
34. Rehm M, Huber HJ, Hellwig CT, Anguissola S, Dussmann H, Prehn JH. Dynamics of outer mitochondrial membrane permeabilization during apoptosis. Cell Death Differ 2009;16:613-23.
35. Fan JY, Cui ZQ, Wei HP, Zhang ZP, Zhou YF, Wang YP, et al. Split mCherry as a new red bimolecular fluorescence complementation system for visualizing protein-protein interactions in living cells. Biochem Biophys Res Commun 2008;367:47-53.
36. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.