Plasma midregional proadrenomedullin in newborn infants: Impact of prematurity and perinatal infection

Pediatric Research

Volumn 72, Issue 1, 2012, Pages 70-76

  Admaty, Deborah ^a   Benzing, Jörg ^b   Burkhardt, Tilo ^a   Lapaire, Olav ^c   Hegi, Lukas ^b   Szinnai, Gabor ^b   Morgenthaler, Nils G ^d   Bucher, Hans Ulrich ^a   Bührer, Christoph ^d   Wellmann, Sven ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MIDREGIONAL PROADRENOMEDULLIN; PROADRENOMEDULLIN; UNCLASSIFIED DRUG;

ARTICLE; BIRTH WEIGHT; BLOOD SAMPLING; CHORIOAMNIONITIS; GESTATIONAL AGE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; NEWBORN; PERINATAL INFECTION; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; UMBILICAL ARTERY; UMBILICAL CORD; UMBILICAL CORD BLOOD; UMBILICAL VEIN;

ADRENOMEDULLIN; BIRTH WEIGHT; CROSS-SECTIONAL STUDIES; FEMALE; GESTATIONAL AGE; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; INFECTION; MALE; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; REGRESSION ANALYSIS;

EID: 84862565853     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.38     Document Type: Article

References (42)

1. Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993;192:553-60. (Pubitemid 23227359)
2. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 2000;21:138-67. (Pubitemid 32275593)
3. Beltowski J, Jamroz A. Adrenomedullin-what do we know 10 years since its discovery? Pol J Pharmacol 2004;56:5-27. (Pubitemid 38515282)
4. Li M, Yee D, Magnuson TR, Smithies O, Caron KM. Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. J Clin Invest 2006;116:2653-62. (Pubitemid 44511629)
5. Chan D, Ng LL. Biomarkers in acute myocardial infarction. BMC Med 2010;8:34.
6. Christ-Crain M, Opal SM. Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia. Crit Care 2010;14:203.
7. Boldt T, Luukkainen P, Fyhrquist F, Pohjavuori M, Andersson S. Birth stress increases adrenomedullin in the newborn. Acta Paediatr 1998;87:93-4. (Pubitemid 28086613)
8. Di Iorio R, Marinoni E, Letizia C, Alò P, Villaccio B, Cosmi EV. Adrenomedullin, a new vasoactive peptide, is increased in preeclampsia. Hypertension 1998;32:758-63. (Pubitemid 28480557)
9. Di Iorio R, Marinoni E, Letizia C, Gazzolo D, Lucchini C, Cosmi EV. Adrenomedullin is increased in the fetoplacental circulation in intrauterine growth restriction with abnormal umbilical artery waveforms. Am J Obstet Gynecol 2000;182:650-4. (Pubitemid 30207328)
10. Yamashiro C, Hayashi K, Yanagihara T, Hata T. Plasma adrenomedullin levels in pregnancies with appropriate for gestational age and small for gestational age infants. J Perinat Med 2001;29:513-8. (Pubitemid 33130996)
11. Akturk A, Onal EE, Atalay Y, et al. Maternal and umbilical venous adrenomedullin and nitric oxide levels in intrauterine growth restriction. J Matern Fetal Neonatal Med 2007;20:521-5. (Pubitemid 47221571)
12. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem 2005;51:1823-9. (Pubitemid 41368172)
13. Knerr I, Dachert C, Beinder E, et al. Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome. Eur J Obstet Gynecol Reprod Biol 2002;101:47-53. (Pubitemid 34142246)
14. Kanenishi K, Kuwabara H, Ueno M, Sakamoto H, Hata T. Immunohistochemical adrenomedullin expression is decreased in the placenta from pregnancies with pre-eclampsia. Pathol Int 2000;50:536-40. (Pubitemid 30609861)
15. Jerat S, Morrish DW, Davidge ST, Kaufman S. Effect of adrenomedullin on placental arteries in normal and preeclamptic pregnancies. Hypertension 2001;37:227-31. (Pubitemid 32199079)
16. Al-Ghafra A, Gude NM, Brennecke SP, King RG. Increased adrenomedullin protein content and mRNA expression in human fetal membranes but not placental tissue in pre-eclampsia. Mol Hum Reprod 2006;12:181-6.
17. Gazzolo D, Marinoni E, Giovannini L, Letizia C, Serra G, Di Iorio R. Circulating adrenomedullin is increased in preterm newborns developing intraventricular hemorrhage. Pediatr Res 2001;50:544-7. (Pubitemid 32911348)
18. Di Iorio R, Marinoni E, Lituania M, et al. Adrenomedullin increases in term asphyxiated newborns developing intraventricular hemorrhage. Clin Biochem 2004;37:1112-6. (Pubitemid 39601100)
19. Miguel D, Prieto B, Costa M, Coto D, Alvarez FV. Cord blood plasma reference intervals for potential sepsis markers: pro-adrenomedullin, pro-endothelin, and pro-atrial natriuretic peptide. Clin Biochem 2011;44:337-41.
20. Maisel A, Mueller C, Nowak R, et al. Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH(Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol 2010;55: 2062-76.
21. Schuetz P, Wolbers M, Christ-Crain M, et al.; ProHOSP Study Group. Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care 2010;14:R106.
22. Di Iorio R, Marinoni E, Scavo D, Letizia C, Cosmi EV. Adrenomedullin in pregnancy. Lancet 1997;349:328.
23. Fanaroff JM, Fanaroff AA. Blood pressure disorders in the neonate: hypotension and hypertension. Semin Fetal Neonatal Med 2006;11:174-81. (Pubitemid 44382477)
24. Barrington KJ. Low blood pressure in extremely preterm infants: does treatment affect outcome? Arch Dis Child Fetal Neonatal Ed 2011;96: F316-7.
25. Kamata S, Kamiyama M, Usui N, et al. Is adrenomedullin involved in the pathophysiology of persistent pulmonary hypertension of the newborn? Pediatr Surg Int 2004;20:24-6. (Pubitemid 40590604)
26. Nishikimi T, Matsuoka H, Shimada K, Matsuo H, Kangawa K. Production and clearance sites of two molecular forms of adrenomedullin in human plasma. Am J Hypertens 2000;13:1032-4.
27. Marinoni E, Di Iorio R, Alò P, Villaccio B, Alberini A, Cosmi EV. Immunohistochemical localization of adrenomedullin in fetal and neonatal lung. Pediatr Res 1999;45:282-5. (Pubitemid 29076009)
28. Sugo S, Minamino N, Shoji H, et al. Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun 1995;207:25-32.
29. Shoji H, Minamino N, Kangawa K, Matsuo H. Endotoxin markedly elevates plasma concentration and gene transcription of adrenomedullin in rat. Biochem Biophys Res Commun 1995;215:531-7.
30. Hirata Y, Mitaka C, Sato K, et al. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 1996;81:1449-53. (Pubitemid 26118575)
31. Christ-Crain M, Morgenthaler NG, Struck J, Harbarth S, Bergmann A, Müller B. Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study. Crit Care 2005;9:R816-24.
32. Hagag AA, Elmahdy HS, Ezzat AA. Prognostic value of plasma pro-adrenomedullin and antithrombin levels in neonatal sepsis. Indian Pediatr 2011;48:471-3.
33. Fowler DE, Yang S, Zhou M, Chaudry IH, Simms HH, Wang P. Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response. J Surg Res 2003;109:175-81. (Pubitemid 36315746)
34. Trollmann R, Schoof E, Beinder E, Wenzel D, Rascher W, Dotsch J. Adrenomedullin gene expression in human placental tissue and leukocytes: a potential marker of severe tissue hypoxia in neonates with birth asphyxia. Eur J Endocrinol 2002;147:711-6. (Pubitemid 35414570)
35. Jensen RI, Carter AM, Skøtt O, Jensen BL. Adrenomedullin expression during hypoxia in fetal sheep. Acta Physiol Scand 2005;183:219-28. (Pubitemid 40203615)
36. Marinoni E, Pacioni K, Sambuchini A, Moscarini M, Letizia C, Di Iorio R. Regulation by hypoxia of adrenomedullin output and expression in human trophoblast cells. Eur J Obstet Gynecol Reprod Biol 2011;154: 146-50.
37. Wellmann S, Benzing J, Cippà G, et al. High copeptin concentrations in umbilical cord blood after vaginal delivery and birth acidosis. J Clin Endocrinol Metab 2010;95:5091-6.
38. Benzing J, Wellmann S, Achini F, et al. Plasma copeptin in preterm infants: a highly sensitive marker of fetal and neonatal stress. J Clin Endocrinol Metab 2011;96:E982-5.
39. Caruhel P, Mazier C, Kunde J, Morgenthaler NG, Darbouret B. Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system B.R.A.H.M.S KRYPTOR. Clin Biochem 2009;42:725-8.
40. Benirschke K, Kaufmann P, Baergen RN. Pathology of the Human Placenta. 5th edn. Berlin: Springer, 2006.
41. Schlapbach LJ, Ersch J, Adams M, Bernet V, Bucher HU, Latal B. Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational age. Acta Paediatr 2010;99:1504-9.
42. Letzner J, Berger F, Schwabe S, et al. Plasma C-terminal pro-endothelin-1 and the natriuretic pro-peptides NT-proBNP and MR-proANP in very preterm infants with patent ductus arteriosus. Neonatology 2012;101:116-24.