메뉴 건너뛰기




Volumn 109, Issue 25, 2012, Pages 10071-10076

Loss of functional GABA A receptors in the Alzheimer diseased brain

Author keywords

Gephyrin; Glutamate receptor; Neurodegeneration; Synaptic mechanism

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; BENZODIAZEPINE; GEPHYRIN; GLUTAMATE RECEPTOR; MESSENGER RNA; VOLTAGE DEPENDENT ANION CHANNEL;

EID: 84862560975     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204606109     Document Type: Article
Times cited : (221)

References (46)
  • 1
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298:789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 2
    • 79954994735 scopus 로고    scopus 로고
    • Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease
    • Rissman RA, Mobley WC (2011) Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem 117:613-622.
    • (2011) J Neurochem , vol.117 , pp. 613-622
    • Rissman, R.A.1    Mobley, W.C.2
  • 3
    • 80052266362 scopus 로고    scopus 로고
    • Neurosteroid andGABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis
    • Luchetti S, Huitinga I, Swaab DF (2011) Neurosteroid andGABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis. Neuroscience 191:6-21.
    • (2011) Neuroscience , vol.191 , pp. 6-21
    • Luchetti, S.1    Huitinga, I.2    Swaab, D.F.3
  • 4
    • 54049137689 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function
    • Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 60:243-260.
    • (2008) Update. Pharmacol Rev , vol.60 , pp. 243-260
    • Olsen, R.W.1    Sieghart, W.2
  • 5
    • 4043070505 scopus 로고    scopus 로고
    • GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia
    • Lanctôt KL, Herrmann N, Mazzotta P, Khan LR, Ingber N (2004) GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Can J Psychiatry 49:439-453.
    • (2004) Can J Psychiatry , vol.49 , pp. 439-453
    • Lanctôt, K.L.1    Herrmann, N.2    Mazzotta, P.3    Khan, L.R.4    Ingber, N.5
  • 6
    • 0026538576 scopus 로고
    • The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-dependent anion channel (VDAC)
    • McEnery MW (1992) The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-dependent anion channel (VDAC). J Bioenerg Biomembr 24:63-69.
    • (1992) J Bioenerg Biomembr , vol.24 , pp. 63-69
    • McEnery, M.W.1
  • 7
    • 61449203017 scopus 로고    scopus 로고
    • The translocator protein (18 kDa): Central nervous system disease and drug design
    • Scarf AM, Ittner LM, Kassiou M (2009) The translocator protein (18 kDa): central nervous system disease and drug design. J Med Chem 52:581-592.
    • (2009) J Med Chem , vol.52 , pp. 581-592
    • Scarf, A.M.1    Ittner, L.M.2    Kassiou, M.3
  • 8
    • 65349120620 scopus 로고    scopus 로고
    • Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
    • Cosenza-Nashat M, et al. (2009) Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol 35:306-328.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 306-328
    • Cosenza-Nashat, M.1
  • 9
    • 0032078390 scopus 로고    scopus 로고
    • GABAA receptor β 2 and β 3 subunits mRNA in the hippocampal formation of aged human brain with Alzheimer-related neuropathology
    • Mizukami K, Grayson DR, Ikonomovic MD, Sheffield R, Armstrong DM (1998) GABAA receptor β 2 and β 3 subunits mRNA in the hippocampal formation of aged human brain with Alzheimer-related neuropathology. Brain Res Mol Brain Res 56:268-272.
    • (1998) Brain Res Mol Brain Res , vol.56 , pp. 268-272
    • Mizukami, K.1    Grayson, D.R.2    Ikonomovic, M.D.3    Sheffield, R.4    Armstrong, D.M.5
  • 10
    • 1242297051 scopus 로고    scopus 로고
    • Microtransplantation of functional receptors and channels from the Alzheimer's brain to frog oocytes
    • Miledi R, Dueñas Z, Martinez-Torres A, Kawas CH, Eusebi F (2004) Microtransplantation of functional receptors and channels from the Alzheimer's brain to frog oocytes. Proc Natl Acad Sci USA 101:1760-1763.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1760-1763
    • Miledi, R.1    Dueñas, Z.2    Martinez-Torres, A.3    Kawas, C.H.4    Eusebi, F.5
  • 11
    • 33847263546 scopus 로고    scopus 로고
    • Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes
    • Bernareggi A, Dueñas Z, Reyes-Ruiz JM, Ruzzier F, Miledi R (2007) Properties of glutamate receptors of Alzheimer's disease brain transplanted to frog oocytes. Proc Natl Acad Sci USA 104:2956-2960.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2956-2960
    • Bernareggi, A.1    Dueñas, Z.2    Reyes-Ruiz, J.M.3    Ruzzier, F.4    Miledi, R.5
  • 12
    • 0037031566 scopus 로고    scopus 로고
    • Motor cortex excitability in Alzheimer disease: One year follow-up study
    • Pennisi G, et al. (2002) Motor cortex excitability in Alzheimer disease: One year follow-up study. Neurosci Lett 329:293-296.
    • (2002) Neurosci Lett , vol.329 , pp. 293-296
    • Pennisi, G.1
  • 13
    • 12144285645 scopus 로고    scopus 로고
    • Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease
    • Di Lazzaro V, et al. (2004) Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease. J Neurol Neurosurg Psychiatry 75:555-559.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 555-559
    • Di Lazzaro, V.1
  • 14
    • 45249124737 scopus 로고    scopus 로고
    • Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing
    • Marcade M, et al. (2008) Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem 106:392-404.
    • (2008) J Neurochem , vol.106 , pp. 392-404
    • Marcade, M.1
  • 16
    • 67849119971 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein and protein S-100B: Different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease
    • Jesse S, et al. (2009) Glial fibrillary acidic protein and protein S-100B: Different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease. J Alzheimers Dis 17:541-551.
    • (2009) J Alzheimers Dis , vol.17 , pp. 541-551
    • Jesse, S.1
  • 17
    • 0033580312 scopus 로고    scopus 로고
    • Evolution of GABA(A) receptor diversity in the human genome
    • Russek SJ (1999) Evolution of GABA(A) receptor diversity in the human genome. Gene 227:213-222.
    • (1999) Gene , vol.227 , pp. 213-222
    • Russek, S.J.1
  • 18
    • 0033009936 scopus 로고    scopus 로고
    • Molecular and functional diversity of the expanding GABA-A receptor gene family
    • Whiting PJ, et al. (1999) Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann N Y Acad Sci 868:645-653.
    • (1999) Ann N Y Acad Sci , vol.868 , pp. 645-653
    • Whiting, P.J.1
  • 19
    • 77956292805 scopus 로고    scopus 로고
    • Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex
    • Roden WH, Peugh LD, Jansen LA (2010) Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex. Neurosci Lett 483:167-172.
    • (2010) Neurosci Lett , vol.483 , pp. 167-172
    • Roden, W.H.1    Peugh, L.D.2    Jansen, L.A.3
  • 20
    • 0028350662 scopus 로고
    • AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease
    • Armstrong DM, Ikonomovic MD, Sheffield R, Wenthold RJ (1994) AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer's disease. Brain Res 639:207-216.
    • (1994) Brain Res , vol.639 , pp. 207-216
    • Armstrong, D.M.1    Ikonomovic, M.D.2    Sheffield, R.3    Wenthold, R.J.4
  • 21
    • 69449089052 scopus 로고    scopus 로고
    • Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease
    • Gong Y, Lippa CF, Zhu J, Lin Q, Rosso AL (2009) Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. Brain Res 1292:191-198.
    • (2009) Brain Res , vol.1292 , pp. 191-198
    • Gong, Y.1    Lippa, C.F.2    Zhu, J.3    Lin, Q.4    Rosso, A.L.5
  • 22
    • 0027715150 scopus 로고
    • Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A
    • Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082.
    • (1993) Neuron , vol.11 , pp. 1069-1082
    • Partin, K.M.1    Patneau, D.K.2    Winters, C.A.3    Mayer, M.L.4    Buonanno, A.5
  • 23
    • 3042757542 scopus 로고    scopus 로고
    • Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain
    • Palma E, et al. (2004) Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain. Proc Natl Acad Sci USA 101:10183-10188.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10183-10188
    • Palma, E.1
  • 24
    • 0020644119 scopus 로고
    • A transient calcium-dependent chloride current in the immature Xenopus oocyte
    • Barish ME (1983) A transient calcium-dependent chloride current in the immature Xenopus oocyte. J Physiol 342:309-325.
    • (1983) J Physiol , vol.342 , pp. 309-325
    • Barish, M.E.1
  • 25
    • 2542547342 scopus 로고    scopus 로고
    • Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors
    • Thompson SA, et al. (2004) Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. Br J Pharmacol 142:97-106.
    • (2004) Br J Pharmacol , vol.142 , pp. 97-106
    • Thompson, S.A.1
  • 26
    • 0020520528 scopus 로고
    • Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain
    • Allen SJ, et al. (1983) Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain. J Neurochem 41:256-265.
    • (1983) J Neurochem , vol.41 , pp. 256-265
    • Allen, S.J.1
  • 27
    • 0020973168 scopus 로고
    • [3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type
    • Owen F, Poulter M, Waddington JL, Mashal RD, Crow TJ (1983) [3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type. Brain Res 278:373-375.
    • (1983) Brain Res , vol.278 , pp. 373-375
    • Owen, F.1    Poulter, M.2    Waddington, J.L.3    Mashal, R.D.4    Crow, T.J.5
  • 28
    • 0023472509 scopus 로고
    • Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
    • Coleman PD, Flood DG (1987) Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 8:521-545.
    • (1987) Neurobiol Aging , vol.8 , pp. 521-545
    • Coleman, P.D.1    Flood, D.G.2
  • 29
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain: Morphomolecular senescence of cortical circuits
    • Hof PR, Morrison JH (2004) The aging brain: Morphomolecular senescence of cortical circuits. Trends Neurosci 27:607-613.
    • (2004) Trends Neurosci , vol.27 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 30
    • 34249025187 scopus 로고    scopus 로고
    • Changes in the structural complexity of the aged brain
    • Dickstein DL, et al. (2007) Changes in the structural complexity of the aged brain. Aging Cell 6:275-284.
    • (2007) Aging Cell , vol.6 , pp. 275-284
    • Dickstein, D.L.1
  • 31
    • 54149092555 scopus 로고    scopus 로고
    • Evolution of the aging brain transcriptome and synaptic regulation
    • Loerch PM, et al. (2008) Evolution of the aging brain transcriptome and synaptic regulation. PLoS ONE 3:e3329.
    • (2008) PLoS ONE , vol.3
    • Loerch, P.M.1
  • 32
    • 80051964056 scopus 로고    scopus 로고
    • Aging of the cerebral cortex differs between humans and chimpanzees
    • Sherwood CC, et al. (2011) Aging of the cerebral cortex differs between humans and chimpanzees. Proc Natl Acad Sci USA 108:13029-13034.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 13029-13034
    • Sherwood, C.C.1
  • 33
    • 77249098331 scopus 로고    scopus 로고
    • Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
    • Rabinovici GD, et al. (2010) Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden. Brain 133:512-528.
    • (2010) Brain , vol.133 , pp. 512-528
    • Rabinovici, G.D.1
  • 35
    • 80053131543 scopus 로고    scopus 로고
    • Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques
    • Garcia-Marin V, et al. (2009) Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques. Front Neuroanat 3:28.
    • (2009) Front Neuroanat , vol.3 , pp. 28
    • Garcia-Marin, V.1
  • 36
    • 65649098041 scopus 로고    scopus 로고
    • An immunohistochemical study of GABAA receptor gamma subunits in Alzheimer's disease hippocampus: Relationship to neurofibrillary tangle progression
    • Iwakiri M, et al. (2009) An immunohistochemical study of GABAA receptor gamma subunits in Alzheimer's disease hippocampus: Relationship to neurofibrillary tangle progression. Neuropathology 29:263-269.
    • (2009) Neuropathology , vol.29 , pp. 263-269
    • Iwakiri, M.1
  • 37
    • 47849083572 scopus 로고    scopus 로고
    • Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer's disease
    • Agarwal S, Tannenberg RK, Dodd PR (2008) Reduced expression of the inhibitory synapse scaffolding protein gephyrin in Alzheimer's disease. J Alzheimers Dis 14:313-321.
    • (2008) J Alzheimers Dis , vol.14 , pp. 313-321
    • Agarwal, S.1    Tannenberg, R.K.2    Dodd, P.R.3
  • 38
    • 0028987322 scopus 로고
    • GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes
    • Fraser DD, et al. (1995) GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes. J Neurosci 15:2720-2732.
    • (1995) J Neurosci , vol.15 , pp. 2720-2732
    • Fraser, D.D.1
  • 39
    • 13044283438 scopus 로고    scopus 로고
    • θ, a novel gamma-aminobutyric acid type A receptor subunit
    • Bonnert TP, et al. (1999) θ, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci USA 96:9891-9896.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9891-9896
    • Bonnert, T.P.1
  • 40
    • 33645522413 scopus 로고    scopus 로고
    • Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit
    • Huntsman MM, Huguenard JR (2006) Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit. J Physiol 572:459-475.
    • (2006) J Physiol , vol.572 , pp. 459-475
    • Huntsman, M.M.1    Huguenard, J.R.2
  • 41
    • 31044456936 scopus 로고    scopus 로고
    • Pharmacological properties of GABAA receptors containing gamma1 subunits
    • Khom S, et al. (2006) Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol 69:640-649.
    • (2006) Mol Pharmacol , vol.69 , pp. 640-649
    • Khom, S.1
  • 42
    • 84866044200 scopus 로고    scopus 로고
    • Benzodiazepine use and risk of dementia: Evidence from the Caerphilly Prospective Study (CaPS)
    • 10.1136/jech-2011-200314
    • Gallacher J, et al. (2011) Benzodiazepine use and risk of dementia: Evidence from the Caerphilly Prospective Study (CaPS). J Epidemiol Community Health, 10.1136/jech-2011-200314.
    • (2011) J Epidemiol Community Health
    • Gallacher, J.1
  • 44
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Δ Δ C(T)) Method
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Δ Δ C(T)) Method. Methods 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 46
    • 49449096615 scopus 로고    scopus 로고
    • Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes
    • Limon A, Reyes-Ruiz JM, Miledi R (2008) Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes. Proc Natl Acad Sci USA 105:10973-10977.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10973-10977
    • Limon, A.1    Reyes-Ruiz, J.M.2    Miledi, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.