GABA(A) receptor β2 and β3 subunits mRNA in the hippocampal formation of aged human brain with Alzheimer-related neuropathology

Molecular Brain Research

Volumn 56, Issue 1-2, 1998, Pages 268-272

  Mizukami, Katsuyoshi ^a   Grayson, Dennis R ^a   Ikonomovic, Milos D ^a   Sheffield, Roxanne ^a   Armstrong, David M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; GABA(A) receptor; Hippocampus; In situ hybridization

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; GLUTAMINE; MESSENGER RNA; NEUROTRANSMITTER; RECEPTOR SUBUNIT;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTORADIOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; GRANULE CELL; HIPPOCAMPUS; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; PRIORITY JOURNAL; BRAIN; GENETICS; METABOLISM; PATHOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUTORADIOGRAPHY; BRAIN; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION; RECEPTORS, GABA-A; RNA, MESSENGER;

EID: 0032078390     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00347-1     Document Type: Article

References (22)

1. Armstrong D.M., Ikonomovic M.D. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal dentate gyrus of patients with Alzheimer disease. Evidence for hippocampal plasticity. Mol. Chem. Neuropathol. 28:1996;59-64.
2. Braak H., Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82:1991;239-259.
3. A receptor changes in Alzheimer's disease. Neurosci. Lett. 82:1987;246-252.
4. Cross A.J., Crow T.J., Johnson J.A., Perry E.K., Perry R.H., Blessed G., Tomlinson B.E. Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of the Alzheimer type. J. Neurol. Sci. 64:1984;109-117.
5. H.M. Duvernoy, The Human Hippocampus, J.F. Bergmann Verlag, Munchen, 1988.
6. A/Benzodiazepine receptor. J. Cell Biol. 110:1990;2043-2048.
7. Grayson D.R., Bovolin P., Santi M.R. Absolute quantitation of γ-aminobutyric acid. A receptor subunit messenger RNAs by competitive polymerase chain reaction. Methods Neurosci. 12:1993;191-207.
8. Greenamyre J.T., Penny J.B., D'Amato C.J., Young A.B. Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding. J. Neurochem. 48:1987;543-551.
9. A receptors in the human hippocampal formation. J. Neurosci. 8:1988;1370-1383.
10. Ikonomovic M.D., Sheffield R., Armstrong D.M. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease. Hippocampus. 5:1995;469-486.
11. Jansen K.L.R., Faull R.L.M., Dragunow M., Synek B.L. Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors. An autoradiographic study. Neuroscience. 39:1990;613-627.
12. Lorente de No R. Studies on the structure of the cerebral cortex: II. Continuation of the study of the Ammonic system. J. Psychol. Neurol. 46:1934;113-177.
13. Marlier L.N.J., Zheng T., Tang J., Grayson D.R. Regional distribution in the rat central nervous system of a mRNA encoding a portion of the cardiac sodium/calcium exchanger isolated from cerebellar granule neurons. Mol. Brain Res. 20:1993;21-39.
14. K. Mizukami, M.D. Ikonomovic, D.R. Grayson, R.T. Rubin, D. Warde, R. Sheffield, R.L. Hamilton, P. Davies, D.M. Armstrong, Immunohistochemical study of GABAA receptor β2/3 subunits in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes, Exp. Neurol. (1997), in press.
15. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258:1992;597-603.
16. Palmer A.M., Gershon S. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB J. 4:1990;2745-2752.
17. Penny J.B., Maragos W.F., Greenamyre J.T., Debowey D.L., Hollingsworth Z., Young A.B. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. J. Neurol. Neurosurg. Psychiatry. 53:1990;314-320.
18. A receptor research. Synapse. 21:1995;189-274.
19. Reisine T.D., Yamamura H.I., Bird E.D., Spokes E., Enna S.J. Pre- and post-synaptic neurochemical alterations in Alzheimer's disease. Brain Res. 159:1978;477-481.
20. Shimohama S., Taniguchi T., Fujiwara M., Kameyama M. Changes in benzodiazepine receptors in Alzheimer-type dementia. Ann. Neurol. 23:1988;404-406.
21. A receptor subunit mRNA in the rat brain: I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12:1992;1040-1062.
22. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 8:1989;1665-1670.