The dilemma, causes and approaches to avoid recurrent hospital readmissions for patients with chronic heart failure

Heart Failure Reviews

Volumn 17, Issue 3, 2012, Pages 345-353

  Zaya, Melody ^a   Phan, Anita ^a   Schwarz, Ernst R ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Heart failure; Readmission; Repeat hospitalization; Therapy

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; SPIRONOLACTONE;

ARTICLE; CARDIAC RESYNCHRONIZATION THERAPY; COMMUNITY CARE; DISEASE COURSE; DRUG EFFICACY; FOLLOW UP; HEALTH CARE COST; HEALTH CARE SYSTEM; HEART FAILURE; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; MORBIDITY; MORTALITY; PATIENT EDUCATION; QUALITY OF LIFE; RISK MANAGEMENT; SURVIVAL;

CHRONIC DISEASE; HEART FAILURE; HOSPITALIZATION; HUMANS; PATIENT READMISSION; RISK FACTORS;

EID: 84862553437     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-011-9256-0     Document Type: Article

References (104)

1. American Heart Association. Heart disease and stroke statistics-2009 update (2009) Circulation 119:e21-e181
2. American Heart Association. Heart disease and stroke statistics-2005 update. Dallas, TX: American Heart Association; 2005
3. Merrill CT, Elixhauser A. Hospitalization in the United States, 2002: HCUP Fact Book No. 6. Rockville, MD: Agency for Healthcare Research and Quality; 2005. AHRQ publication 05-0056
4. O'Connell JB, Bristow MR (1994) Economic impact of heart failure in the United States: time for a different approach. J Heart Lung Transplant 13:S107-S111
5. Keenan PS, Normand SL, Lin Z et al (2008) An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. Circ Cardiovasc Qual Outcomes 1:29-37
6. Jencks SF, Williams MV, Coleman EA (2009) Rehospitalizations among patients in the medicare fee-for-service program. N Engl J Med 360:1418-1428
7. Hunt SA, Abraham WT, Chin MH et al (2009) 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. doi: 10.1161/CIRCULATIONAHA.109.192065
8. Sutton MGSJ, Sharper N (2000) Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101:2981-2988
9. Eichhorn EJ, Bristow MR (1996) Medical therapy can improve the biologic function properties of the chronically failing heart: a new era in the treatment of heart failure. Circulation 94:2285-2296
10. Schwarz ER, Schaper J, vom Dahl J et al (1996) Myocyte degeneration and cell death in hibernating human myocardium. J Am Coll Cardiol 7:1577-1585
11. Schwarz ER, Schoendube FA, Kostin S (1998) Prolonged myocardial hibernation exacerbates cardiomyocyte degeneration and impairs recovery of function after revascularization. J Am Coll Cardiol 5:1018-1026
12. Witte KKA, Clark AL, Cleland JGF (2001) Chronic heart failure and micronutrients. J Am Coll Cardiol 37:1765-1774
13. Bhattacharya SK, Ahokas RA, Carbone LD et al (2006) Macroand micronutrients in African-Americans with heart failure. Heart Fail Rev 1:45-55
14. Tsutsui H, Tsuchihashi M, Takeshita A (2001) Mortality and readmission of hospitalized patients with congestive heart failure and preserved versus depressed systolic function. Am J Cardiol 88:530-533
15. Baker DW (2002) Prevention of heart failure. J Card Fail 8: 333-346
16. Maisel WH, Stevenson LW (2003) Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol 91 (6A):2D-8D
17. Jessup M, Brozena S (2003) Heart failure. New Engl J Med 348:2007-2018
18. Aranda JM Jr, Johnson JW, Conti JB (2009) Current trends in heart failure readmission rates: analysis of medicare data. Clin Cardiol 32 (1):47-52
19. Young T, Peppard P, Palta M et al (1997) Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 157:1746-1752
20. Kasai T, Narui K, Dohi T et al (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690-696
21. Kannel W, Hjortland M, Castelli W (1974) Role of diabetes in congestive heart failure. Am J Cardiol 34:29-34
22. Polikar R, Burger AG, Scherrer U, Nicod P (1993) The thyroid and the heart. Circulation 87:1435-1441
23. Cavallo A, Joseph CJ, Casta A (1984) Cardiac complications in juvenile hyperthyroidism. Am J Dis Child 138:479
24. Mac Kerrow SD, Osborn LA, Levy H, Eaton RP, Economou P (1992) Myxedema-associated cardiogenic shock treated with intravenous triiodothyronine. Ann Intern Med 117:1014-1015
25. CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 316:1429-1435
26. SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325:293-302
27. Pfeffer MA, Braunwald E, Moyé LA et al (1992) Effect of captopril on mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction -results of the Survival and Ventricular Enlargement Trial. N Engl J Med 327: 669-677
28. Acute Infarction Ramipril Efficacy (AIRE) Study investigators (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342:821-828
29. Kober L, Torp-Pedersen C, Carlsen JE et al, for the Trandolapril Cardiac Evaluation (TRACE) study group (1995) A clinical-trial of the angiotensinconverting enzyme inhibitor trandolapril in patients with left-ventricular dysfunction after myocardial infarction. N Engl J Med 333:1670-1676
30. Komukai K, Yagi H, Ogawa T et al (2008) Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction. Circ J 72:2004-2008
31. Munzel T, Keaney JF Jr (2001) Are ACE inhibitors the ''magic bullet'' against oxidative stress? Circulation 104:1571-1574
32. Khalil ME, Basher AW, Brown EJ Jr, Alhaddad IA (2001) A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients. J Am Coll Cardiol 37: 1757-1764
33. Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 273:1450-1456
34. Sueta C, Massing MW, Simpson RJ (1999) Undertreatment of older patients with congestive heart failure. J Card Fail 5:66
35. McDonald K, Ledwidge M, Cahill J et al (2001) Elimination of early rehospitalization in a randomized, controlled trial of multidisciplinary care in a high-risk, elderly heart failure population: the potential contributions of specialist care, clinical stability and optimal angiotensin-converting enzyme inhibitor dose at discharge. Eur J Heart Fail 3 (2):209-215
36. Consensus Recommedations for the Management of Chronic Heart Failure (1999) Am J Cardiol 83: 2a-38a
37. Bown Luzier A, Forrest A, Adelman M et al (1998) Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure. Am J Cardiol 82:465-469
38. Packer M, Poole-Wilson PA, Armstrong PW et al (1999) Comparative effects of low and high doses of the angiotensinconverting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. Circulation 100:1-7
39. Pitt B, Zannad F, Remme WJ et al, for the Randomized Aldactone Evaluation Study Investigators (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709-17
40. Jacob MS, Tang WH (2011) Aldosterone-receptor antagonists in heart failure: insights after EMPHASIS-HF. Curr Heart Fail Rep 8 (1):7-13
41. CIBIS-II Investigators Committee (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 353:9-13
42. Study Group MERIT-HF (1999) Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERITHF). Lancet 353:2001-2007
43. Packer M, Coats AJ, Fowler MB et al (2001) Carvedilol prospective randomized cumulative survival study group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651-1658
44. Packer M, Fowler MB, Roecker EB et al (2002) Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106 (17):2194-2199
45. Hernandez AF, Hammill BG, O'Connor CM, Schulman KA, Curtis LH, Fonarow GC (2009) Clinical effectiveness of betablockers in heart failure. Findings from the OPTIMIZE-HF Registry. J Am Coll Cardiol 53:184-192
46. Group TheDigitalisInvestigation (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336:525-533
47. Taylor AL, Ziesche S, Yancy C et al, for the African-American Heart Failure Trial Investigators (2004) Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 351:2049-2057
48. Hamner JB, Ellison KJ (2005) Predictors of hospital readmission after discharge in patients with congestive heart failure. Heart Lung 34:231-239
49. McAlister FA, Stewart S, Ferrua S, McMurray JJJV (2004) Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. J Am Coll Cardiol 44:810-819
50. Cleland JGF, Daubert JC, Erdmann E et al, for the Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539-1549
51. Tang ASL, Wells GA, Talaiic M et al, for the Resynchronization- Defibrillation for Ambulatory Heart Failure Trial (RAFT) Investigators (2010) Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure. N Engl J Med 363:2385-2395
52. Moss AJ, Hall WJ, Cannom DS et al, for the MADIT-CRT Trial Investigators (2009) Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events. N Engl J Med 361 (14): 1329-1338
53. Fonarow GC, Yancy CW, Albert NM et al (2008) Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF. Circ Heart Fail 1:98-106
54. Bourge RC, Abraham WT, Adamson PB et al (2008) Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure (The COMPASS-HF Study). J Am Coll Cardiol 51:1073-1079
55. Ritzema J, Troughton R, Melton I et al (2010) Physiciandirected patient self-management of left-atrial pressure in advanced chronic heart failure. Circulation 116:2952-2959
56. Abraham WT, Adamson PB (2010) Primary results of the CardioMEMS heart sensor allows monitoring of pressure to improve outcomes in NYHA class III heart-failure patients (champion) trial. Heart Failure Congress 2010 May 29-June 1, 2010; Berlin, Germany
57. Krumholtz HM, Parent EM, Tu N et al (1997) Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med 157:99-104
58. Krumholz HM, Chen YT, Wang Y et al (2000) Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J 139 (1, pt 1):72-77
59. Komukai K, Ogawa T, Yagi H et al (2008) Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure. Circ J 72:1152-1157
60. Tsuchihashi M, Tsutsui H, Kodama K et al (2001) Medical and socioenvironmental predictors of hospital readmission in patients with congestive heart failure. Am Heart J 142:e7
61. Dokainish H, Zoghbi WA, Lakkis NM et al (2005) Incremental predictive power of B-type natriuretic peptide and tissue Doppler echocardiography in the prognosis of patients with congestive heart failure. J Am Coll Cardiol 45:1223-1226
62. Alahdab MT, Mansour IN, Napan S, Stamos T (2009) Six minute walk test predicts long-term all-cause mortality and heart failure re-hospitalization in African-American patients hospitalized with acute decompensated heart failure. J Cardiac Fail 15:130-135
63. Damman K, Navis G, Voors AA et al (2007) Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail 13:599-608
64. Smith GL, Lichtman JH, Bracken MB et al (2006) Renal impairment and outcomes in heart failure: systematic review and meta-analysis. J Am Coll Cardiol 47:1987-1996
65. McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW (2004) Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation 109: 1004-1009
66. Goldenberg I, Moss AJ, Hall WJ et al (2006) Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II. Circulation 113:2810-2817
67. Whellan DJ, Ousdigian KT, Al-Khatib SM et al (2010) Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from partners HF study. J Am Coll Cardiol 55:1803-1810
68. Klein L, Massic BM, Leimberger JD et al, for the OPTIMECHF Investigators (2008) Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure (OPTIME-CHF). Circulation 1:25-33
69. Filippatos G, Rossi J, Lloyd-Jones DM et al (2007) Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the acute and chronic therapeutic impact of a vasopressin antagonist in chronic heart failure (ACTIV in CHF) study. J Card Fail 13:360-364
70. Gheorghiade M, Rossi JS, Cotts W et al (2007) Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial. Arch Intern Med 167 (18):1998-2005
71. Felker GM, Gattis WA, Leimberger JD et al (2003) Usefulness of Anemia as a predictor of death and re-hospitalization in patients with decompensated heart failure. Am J Cardiol 92: 625-628
72. Dunlay SM, Gerber Y, Weston SA, Killian JM, Redfield MM, Roger VL (2009) Prognostic value of biomarkers in heart failure: application of novel methods in the community. Circ Heart Fail 2:393-400
73. Manzano-Fernandez S, Boronat-Garcia M, Albaladejo-Otón MD et al (2009) Complementary prognostic value of cystatin C, N-Terminal Pro-B-type natriuretic peptide and cardiac troponin T in patients with acute heart failure. Am J Cardiol 103: 1753-1759
74. Goonewardena SN, Gemignani A, Ronan A et al (2008) Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-Terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure. JACC Cardiovasc Imaging 1 (5):595-601
75. Niizeki T, Takeishi Y, Kitahara T et al (2009) Combination of conventional biomarkers for risk stratification in chronic heart failure. J Cardiol 53:179-187
76. Gackowski D, Isnard R, Golmard JL et al (2004) Comparison of echocardiography and plasma B-type natriuretic peptide for monitoring the response to treatment in acute heart failure. Eur Heart J 25:1788-1796
77. Cheng V, Kazanagra R, Garcia A et al (2001) A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 37:386-391
78. Logeart D, Thabut G, Jourdain P et al (2004) Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43:635-641
79. Jiang W, Alexander J, Christopher E et al (2001) Relationship to increased risk of mortality and re-hospitalization in patients with congestive heart failure. Arch Intern Med 161:1849-1856
80. Albert NM, Fonarow GC, Abraham WT et al (2009) Depression and clinical outcomes in heart failure: an OPTIMIZE-HF analysis. Am J Med 122:366-373
81. Krumholz HM, Butler J, Miller J et al (1998) Prognostic importance of emotional support for elderly patients hospitalized with heart failure. Circulation 80:428-429
82. Chin MH, Goldman L (1997) Correlates of early hospital readmission or death in patients with congestive heart failure. Am J Cardiol 79:1640-1644
83. Alexander M, Grumbach K, Remy L, Rowell R, Massie BM (1999) Congestive heart failure hospitalizations and survival in California: patterns according to race/ethnicity. Am Heart J 137:919-927
84. Ambardekar AV, Fonarow GC, Hernandez AF, Pan W, Yancy CW, Krantz MJ; Get With The Guidelines Steering Committee and Hospitals (2009) Characteristics and in-hospital outcomes for nonadherent patients with heart failure: findings from get with the guidelines-heart failure (GWTG-HF). Am Heart J 158 (4):644-652
85. Heiat A, Gross CP, Krumholz HM (2002) Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 162:682-688
86. Tsuyuki RT, McKelvie RS, Arnold MO et al (2001) Acute precipitants of congestive heart failure exacerbations. Arch Intern Med 161:2337-2342
87. Granger BB, Swedbery K, Ekman I et al, CHARM investigators (2005) Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double blind, randomized, controlled clinical trial. Lancet 366:2005-2011
88. Ghali JK, Kadakia S, Cooper R, Ferlinz J (1988) Precipitating factors leading to decompensation in heart failure: traits among blacks. Arch Intern Med 148:2013-2016
89. Mockler M, O'Loughlin C, Murphy N et al (2009) Causes and consequences of nonpersistence with heart failure medication. Am J Cardiol 103:834-838
90. Fonarow GC, Abraham WT, Albert NM et al, for the OPTIMIZE- HF Investigators and Hospitals (2008) Factors identified as precipitating hospital admission for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med 168: 847-854
91. Ekman I, Norberg A, Lundman B (2000) An intervention aimed at reducing uncertainty in elderly patients with chronic heart failure. Int J Hum Caring 4 (1):7-13
92. Koelling TM, Johnson ML, Cody RJ, Aaronson KD (2005) Discharge education improves clinical outcomes in patients with chronic heart failure. Circulation 111 (2):179-185
93. Ducharme A, Doyon O, White M, Rouleau JL, Brophy JM (2005) Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial. CMAJ 173 (1):40-45
94. Phillips CO, Wright SM, Kern DE, Singa RM, Shepperd S, Rubin HR (2004) Comprehensive discharge planning with postdischarge support for older patients with congestive heart failure. JAMA 291:1358-1367
95. Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl JMed 333 (18):1190-1195
96. Krumholz HM, Amatruda J, Smith GL et al (2002) Randomized trial of an education and support intervention to prevent readmission of patients with heart failure. J Am Coll Cardiol 39 (1): 83-89
97. GESICA Investigators (2005) Randomised trial of telephone intervention in chronic heart failure: DIAL trial. BMJ 331 (7514):425
98. Cline C, Israelsson B, Willenheimer R, Broms K, Erhardt; L (1998) A cost effective management programme for heart failure reduces hospitalisation. Heart 80:442-446
99. Stewart S, Pearson S, Horowitz JD (1998) Effects of a homebased intervention among congestive heart failure patients discharged from acute hospital care. Arch Intern Med 158:1067-1072
100. Doughty RN, Wright SP, Walsh HJ et al (2002) Randomised, controlled trial of integrated heart failure management: the auckland heart failure management study. Eur Heart J 23: 139-146
101. Blue L, Lang E, McMurray JJV et al (2001) Randomised controlled of specialist nurse intervention in heart failure. BMJ 323:715-718
102. Naylor MD, Brooten D, Campbell R et al (1999) Comprehensive discharge planning and home follow-up of hospitalized elders: a randomized clinical trial. JAMA 281:613-620
103. Stewart S, Horowitz JD (2002) Home-based intervention in congestive heart failure; long-term implications in readmission and survival. Circulation 105:2861-2866
104. Ross JS, Chen J, Lin Z et al (2010) Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail 1:97-103