-
1
-
-
0036483747
-
Racemization of aspartic acid in human proteins
-
DOI 10.1016/S0047-6374(01)00363-3, PII S0047637401003633
-
Ritz-Timme S, Collins MJ (2002) Racemization of aspartic acid in human proteins. Ageing Res Rev 1:43-59. (Pubitemid 38340351)
-
(2002)
Ageing Research Reviews
, vol.1
, Issue.1
, pp. 43-59
-
-
Ritz-Timme, S.1
Collins, M.J.2
-
2
-
-
77949531289
-
Are ancient proteins responsible for the age-related decline in health and fitness?
-
Truscott RJW (2010) Are ancient proteins responsible for the age-related decline in health and fitness? Rejuvenation Res 13:83-89.
-
(2010)
Rejuvenation Res
, vol.13
, pp. 83-89
-
-
Truscott, R.J.W.1
-
3
-
-
0025780051
-
Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon
-
Shapiro S, Endicott S, Province M, Pierce J, Campbell E (1991) Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 87:1828-1834.
-
(1991)
J Clin Invest
, vol.87
, pp. 1828-1834
-
-
Shapiro, S.1
Endicott, S.2
Province, M.3
Pierce, J.4
Campbell, E.5
-
4
-
-
0026470470
-
On the accumulation of D-aspartate in elastin and other proteins of the ageing aorta
-
Powell J, Vine N, Crossman M (1992) On the accumulation of D-aspartate in elastin and other proteins of the ageing aorta. Atherosclerosis 97:201-208.
-
(1992)
Atherosclerosis
, vol.97
, pp. 201-208
-
-
Powell, J.1
Vine, N.2
Crossman, M.3
-
5
-
-
0023878488
-
Racemization of individual aspartate residues in human myelin basic protein
-
Shapira R, Wilkinson KD, Shapira G (1988) Racemization of individual aspartate residues in human myelin basic protein. J Neurochem 50:649-654. (Pubitemid 18042342)
-
(1988)
Journal of Neurochemistry
, vol.50
, Issue.2
, pp. 649-654
-
-
Shapira, R.1
Wilkinson, K.D.2
Shapira, G.3
-
6
-
-
0001359236
-
Aspartic acid racemization in tooth enamel from living humans
-
Helfman PM, Bada JL (1975) Aspartic acid racemization in tooth enamel from living humans. Proc Natl Acad Sci USA 72:2891-2894.
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, pp. 2891-2894
-
-
Helfman, P.M.1
Bada, J.L.2
-
7
-
-
45149103497
-
Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life
-
Lynnerup N, Kjeldsen H, Heegaard S, Jacobsen C, Heinemeier J (2008) Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life. PLoS One 1:1529-1531.
-
(2008)
PLoS One
, vol.1
, pp. 1529-1531
-
-
Lynnerup, N.1
Kjeldsen, H.2
Heegaard, S.3
Jacobsen, C.4
Heinemeier, J.5
-
8
-
-
24944483800
-
γ-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans
-
Sun H, Ma Z, Li Y, Liu B, Li Z, Ding X, Gao Y, Ma W, Tang X, Li X, Shen Y (2005) γ-S crystallin gene (CRYGS) mutation causes dominant progressive cortical cataract in humans. J Med Genet 42:706-710.
-
(2005)
J Med Genet
, vol.42
, pp. 706-710
-
-
Sun, H.1
Ma, Z.2
Li, Y.3
Liu, B.4
Li, Z.5
Ding, X.6
Gao, Y.7
Ma, W.8
Tang, X.9
Li, X.10
Shen, Y.11
-
9
-
-
62849103664
-
Novel mutation in the γ-S crystallin gene causing autosomal dominant cataract
-
Vanita V, Singh JR, Singh D, Varon R, Sperling K (2009) Novel mutation in the γ-S crystallin gene causing autosomal dominant cataract. Mol Vis 15:476-481.
-
(2009)
Mol Vis
, vol.15
, pp. 476-481
-
-
Vanita, V.1
Singh, J.R.2
Singh, D.3
Varon, R.4
Sperling, K.5
-
10
-
-
33750078696
-
Glutamine deamidation destabilizes human γD-crystallin and lowers the kinetic barrier to unfolding
-
DOI 10.1074/jbc.M603882200
-
Flaugh SL, Mills IA, King J (2006) Glutamine deamidation destabilizes human γD-crystallin and lowers the kinetic barrier to unfolding. J Biol Chem 281:30782-30793. (Pubitemid 44582133)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.41
, pp. 30782-30793
-
-
Flaugh, S.L.1
Mills, I.A.2
King, J.3
-
11
-
-
0034827607
-
Deamidation of Asn-143 of γS crystallin from protein aggregates of the human lens
-
Takemoto L (2001) Deamidation of Asn-143 of γS crystallin from protein aggregates of the human lens. Curr Eye Res 22:148-153.
-
(2001)
Curr Eye Res
, vol.22
, pp. 148-153
-
-
Takemoto, L.1
-
12
-
-
0034714274
-
Specific glutamine and asparagine residues of γ-S crystallin are resistant to in vivo deamidation
-
Takemoto L, Boyle D (2000) Specific glutamine and asparagine residues of γ-S crystallin are resistant to in vivo deamidation. J Biol Chem 275:26109-26112.
-
(2000)
J Biol Chem
, vol.275
, pp. 26109-26112
-
-
Takemoto, L.1
Boyle, D.2
-
13
-
-
77953276375
-
Age-dependent deamidation of life-long proteins in the human lens
-
Hains P, Truscott RJ (2010) Age-dependent deamidation of life-long proteins in the human lens. Invest Opthalmol Vis Sci 51:3107-3114.
-
(2010)
Invest Opthalmol Vis Sci
, vol.51
, pp. 3107-3114
-
-
Hains, P.1
Truscott, R.J.2
-
14
-
-
0032170644
-
Deamidation and disulfide bonding in human lens γ-crystallins
-
DOI 10.1006/exer.1998.0530
-
Hanson SRA, Smith DL, Smith JB (1998) Deamidation and disulfide bonding in human lens [γ]-crystallins. Exp Eye Res 67:301-312. (Pubitemid 28483229)
-
(1998)
Experimental Eye Research
, vol.67
, Issue.3
, pp. 301-312
-
-
Hanson, S.R.A.1
Smith, D.L.2
Smith, J.B.3
-
15
-
-
33750142707
-
Age-related changes in human crystalline determined from comparative analysis of post-translational modifications in young and aged lens: Does deamidation contribute to crystallin insolubility?
-
DOI 10.1021/pr050473a
-
Wilmarth PA, Tanner S, Dasari S, Nagalla SR, Riviere MA, Bafna V, Pevzner PA, David LL (2006) Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility? J Proteome Res 5:2554-2566. (Pubitemid 44595158)
-
(2006)
Journal of Proteome Research
, vol.5
, Issue.10
, pp. 2554-2566
-
-
Wilmarth, P.A.1
Tanner, S.2
Dasari, S.3
Nagalla, S.R.4
Riviere, M.A.5
Bafha, V.6
Pevzner, P.A.7
David, L.L.8
-
16
-
-
0032128077
-
Age-related changes in human lens crystallins identified by HPLC and mass spectrometry
-
DOI 10.1006/exer.1998.0482
-
Ma Z, Hanson SRA, Lampi KJ, David LL, Smith DL, Smith JB (1998) Age-related changes in human lens crystallins identified by HPLC and mass spectrometry. Exp Eye Res 67:21-30. (Pubitemid 28364811)
-
(1998)
Experimental Eye Research
, vol.67
, Issue.1
, pp. 21-30
-
-
Ma, Z.1
Hanson, S.R.A.2
Lampi, K.J.3
David, L.L.4
Smith, D.L.5
Smith, J.B.6
-
17
-
-
0027416998
-
Age-dependent deamidation of αB-crystallin
-
Groenen PJTA, van Dongen MJP, Voorter CEM, Bloemendal H, de Jong WW (1993) Age-dependent deamidation of αB-crystallin. FEBS Lett 322:69-72.
-
(1993)
FEBS Lett
, vol.322
, pp. 69-72
-
-
Groenen, P.1
Van Dongen, M.J.P.2
Voorter, C.E.M.3
Bloemendal, H.4
De Jong, W.W.5
-
18
-
-
0032128377
-
Age-related changes in human lens crystallins identified by two- dimensional electrophoresis and mass spectrometry
-
DOI 10.1006/exer.1998.0481
-
Lampi KJ, Ma Z, Hanson SRA, Azuma M, Shih M, Shearer TR, Smith DL, Smith JB, David LL (1998) Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry. Exp Eye Res 67:31-43. (Pubitemid 28364812)
-
(1998)
Experimental Eye Research
, vol.67
, Issue.1
, pp. 31-43
-
-
Lampi, K.J.1
Ma, Z.2
Hanson, S.R.A.3
Azuma, M.4
Shih, M.5
Shearer, T.R.6
Smith, D.L.7
Smith, J.B.8
David, L.L.9
-
19
-
-
0034885731
-
Age-dependent deamidation of asparagine residues in proteins
-
DOI 10.1016/S0531-5565(01)00140-1, PII S0531556501001401
-
Lindner H, Helliger W (2001) Age-dependent deamidation of asparagine residues in proteins. Exp Gerontol 36:1551-1563. (Pubitemid 32768731)
-
(2001)
Experimental Gerontology
, vol.36
, Issue.9
, pp. 1551-1563
-
-
Lindner, H.1
Helliger, W.2
-
21
-
-
0037047002
-
Deamidation in human γS-crystallin from cataractous lenses is influenced by surface exposure
-
DOI 10.1021/bi015924t
-
Lapko VN, Purkiss AG, Smith DL, Smith JB (2002) Deamidation in human γS-crystallin from cataractous lenses is influenced by surface exposure. Biochemistry 41:8638-8648. (Pubitemid 34743303)
-
(2002)
Biochemistry
, vol.41
, Issue.27
, pp. 8638-8648
-
-
Lapko, V.N.1
Purkiss, A.G.2
Smith, D.L.3
Smith, J.B.4
-
22
-
-
0023464863
-
Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins
-
Clarke S (1987) Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins. Int J Pept Prot Res 30:808-821.
-
(1987)
Int J Pept Prot Res
, vol.30
, pp. 808-821
-
-
Clarke, S.1
-
23
-
-
0033829222
-
The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage
-
Hanson SR, Hasan A, Smith DL, Smith JB (2000) The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavage. Exp Eye Res 71:195.
-
(2000)
Exp Eye Res
, vol.71
, pp. 195
-
-
Hanson, S.R.1
Hasan, A.2
Smith, D.L.3
Smith, J.B.4
-
27
-
-
0023109951
-
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation
-
Geiger T, Clarke S (1987) Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. J Biol Chem 262:785-794. (Pubitemid 17005254)
-
(1987)
Journal of Biological Chemistry
, vol.262
, Issue.2
, pp. 785-794
-
-
Geiger, T.1
Clarke, S.2
-
28
-
-
0024516367
-
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins
-
Stephenson RC, Clarke S (1989) Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins. J Biol Chem 264:6164-6170. (Pubitemid 19106686)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.11
, pp. 6164-6170
-
-
Stephenson, R.C.1
Clarke, S.2
-
29
-
-
84870904595
-
Fast and scriptable molecular graphics in web browsers without Java3D
-
doi: 10.1038/npre.2007.50.1
-
Willighagen EL, Howard M (2007) Fast and scriptable molecular graphics in web browsers without Java3D. Nat Proc. doi: 10.1038/npre.2007.50.1.
-
(2007)
Nat Proc
-
-
Willighagen, E.L.1
Howard, M.2
-
30
-
-
0037040233
-
The X-ray crystal structure of human γS-crystallin C-terminal domain
-
DOI 10.1074/jbc.M110083200
-
Purkiss AG, Bateman OA, Goodfellow JM, Lubsen NH, Slingsby C (2002) The X-ray crystal structure of human γ S-crystallin C-terminal domain. J Biol Chem 277:4199-4205. (Pubitemid 34968682)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.6
, pp. 4199-4205
-
-
Purkiss, A.G.1
Bateman, O.A.2
Goodfellow, J.M.3
Lubsen, N.H.4
Slingsby, C.5
-
31
-
-
50049119429
-
Deamidation destabilizes and triggers aggregation of a lens proteins, A3 crystallin
-
Takata T, Oxford JT, Demeler B, Lampi KJ (2008) Deamidation destabilizes and triggers aggregation of a lens proteins, A3 crystallin. Protein Sci 17:1565-1575.
-
(2008)
Protein Sci
, vol.17
, pp. 1565-1575
-
-
Takata, T.1
Oxford, J.T.2
Demeler, B.3
Lampi, K.J.4
-
32
-
-
0347358073
-
Effect of Deamidation of Asparagine 146 on Functional and Structural Properties of Human Lens αB-Crystallin
-
DOI 10.1167/iovs.03-0720
-
Gupta R, Srivastava OP (2004) Effect of deamidation of asparagine 146 on functional and structural properties of human lens αB-crystallin. Invest Ophthal Vis Sci 45:206-214. (Pubitemid 38055689)
-
(2004)
Investigative Ophthalmology and Visual Science
, vol.45
, Issue.1
, pp. 206-214
-
-
Gupta, R.1
Srivastava, O.P.2
-
33
-
-
0034780550
-
Deamidation of human βB1 alters the elongated structure of the dimer
-
DOI 10.1006/exer.2000.0950
-
Lampi KJ, Oxford JT, Bachinger HP, Shearer TR, David LL, Kapfer DM (2001) Deamidation of human βB1 alters the elongated structure of the dimer. Exp Eye Res 72:279-288. (Pubitemid 32977981)
-
(2001)
Experimental Eye Research
, vol.72
, Issue.3
, pp. 279-288
-
-
Lampi, K.J.1
Oxford, J.T.2
Bachinger, H.P.3
Shearer, T.R.4
David, L.L.5
Kapfer, D.M.6
-
34
-
-
0034050880
-
Molecular basis of a progressive juvenile-onset hereditary cataract
-
DOI 10.1073/pnas.040554397
-
Pande A, Pande J, Asherie N, Lomakin A, Ogun O, King JA, Lubsen NH, Walton D, Benedek GB (2000) Molecular basis of a progressive juvenile-onset hereditary cataract. Proc Natl Acad Sci USA 97:1993-1998. (Pubitemid 30134010)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.5
, pp. 1993-1998
-
-
Pande, A.1
Pande, J.2
Asherie, N.3
Lomakin, A.4
Ogun, O.5
King, J.A.6
Lubsen, N.H.7
Walton, D.8
Benedek, G.B.9
-
35
-
-
0037449145
-
High-resolution X-ray crystal structures of human γD crystallin (1.25 Å) and the R58H mutant (1.15 Å) associated with aculeiform cataract
-
DOI 10.1016/S0022-2836(03)00375-9
-
Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J (2003) High-resolution X-ray crystal structures of human γD crystallin (1.25 Å) and the R58H mutant (1.15 Å) associated with aculeiform cataract. J Mol Biol 328:1137-1147. (Pubitemid 36506879)
-
(2003)
Journal of Molecular Biology
, vol.328
, Issue.5
, pp. 1137-1147
-
-
Basak, A.1
Bateman, O.2
Slingsby, C.3
Pande, A.4
Asherie, N.5
Ogun, O.6
Benedek, G.B.7
Pande, J.8
-
37
-
-
84865661787
-
Race-misation of two proteins over our lifespan. Deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range
-
in press doi: 10.1167/iovs.11-9085
-
Hooi MYS, Raftery MJ, Truscott RJW (in press) Race-misation of two proteins over our lifespan. Deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range. Invest Ophthal Vis Sci. doi: 10.1167/iovs.11-9085.
-
Invest Ophthal Vis Sci
-
-
Hooi, M.Y.S.1
Raftery, M.J.2
Truscott, R.J.W.3
-
38
-
-
0037163034
-
The influence of protein structure on the products emerging from succinimide hydrolysis
-
DOI 10.1074/jbc.M205314200
-
Athmer L, Kindrachuk J, Georges F, Napper S (2002) The influence of protein structure on the products emerging from succinimide hydrolysis. J Biol Chem 277:30502-30507. (Pubitemid 34970742)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.34
, pp. 30502-30507
-
-
Athmer, L.1
Kindrachuk, J.2
Georges, F.3
Napper, S.4
-
39
-
-
0034829887
-
Neighboring side chain effects on asparaginyl and aspartyl degradation: An Ab initio study of the relationship between peptide conformation and backbone NH acidity
-
DOI 10.1021/ja0026814
-
Radkiewicz JL, Zipse H, Clarke S, Houk KN (2001) Neighboring side chain effects on asparaginyl and aspartyl degradation: an ab initio study of the relationship between peptide conformation and backbone NH acidity. J Am Chem Soc 123:3499-3506. (Pubitemid 32884584)
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.15
, pp. 3499-3506
-
-
Radkiewicz, J.L.1
Zipse, H.2
Clarke, S.3
Houk, K.N.4
-
40
-
-
58249089343
-
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells
-
D'Angelo MA, Raices M, Panowski SH, Hetzer MW (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136:284-295.
-
(2009)
Cell
, vol.136
, pp. 284-295
-
-
D'Angelo, M.A.1
Raices, M.2
Panowski, S.H.3
Hetzer, M.W.4
-
41
-
-
79959554464
-
Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses
-
Hooi M, Truscott R (2011) Racemisation and human cataract. D-Ser, D-Asp/Asn and D-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses. AGE 33:131-141.
-
(2011)
AGE
, vol.33
, pp. 131-141
-
-
Hooi, M.1
Truscott, R.2
|