Glucocorticoid treatment does not alter early cardiac adaptations to growth restriction in preterm sheep fetuses

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 119, Issue 8, 2012, Pages 906-914

  Tare, M ^a   Miller, S L ^a   Wallace, E M ^a   Sutherland, A E ^a   Yawno, T ^a   Coleman, H A ^a   Jenkin, G ^a   Parkington, H C ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

betamethasone; fetal growth restriction; ischaemia reperfusion infarct area; Langendorff heart

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BALLOON CATHETER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORTICOSTEROID THERAPY; DISEASE PREDISPOSITION; EWE; FETUS; HEART DISEASE; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE PRESSURE; HEART SIZE; HEART VENTRICLE CONTRACTION; INTRAUTERINE GROWTH RETARDATION; ISCHEMIA; ISOLATED HEART; NONHUMAN; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; REPERFUSION INJURY; RISK BENEFIT ANALYSIS; SINGLE UMBILICAL ARTERY LIGATION;

ADAPTATION, PHYSIOLOGICAL; ADRENERGIC BETA-AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BETAMETHASONE; BLOOD PRESSURE; CORONARY CIRCULATION; FEMALE; FETAL GROWTH RETARDATION; FETAL HEART; GLUCOCORTICOIDS; HEART RATE, FETAL; ISOPROTERENOL; LIGATION; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; SHEEP, DOMESTIC; UMBILICAL ARTERIES; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT;

EID: 84862528134     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2012.03309.x     Document Type: Article

References (46)

1. National Institutes of Health Consensus Development P. Antenatal Corticosteroids Revisited: Repeat Courses-National Institutes of Health Consensus Development Conference Statement, 2000. Obstet Gynecol 2001; 98: 144-50.
2. Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, Wintour EM,. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol 1992; 77: 709-17.
3. Schwab M, Roedel M, Anwar MA, Muller T, Schubert H, Buchwalder LF, et al., Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 2000; 528: 619-32.
4. Miller SL, Chai M, Loose J, Castillo-Melendez M, Walker DW, Jenkin G, et al., The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology 2007; 148: 1288-95.
5. Koenen SV, Mecenas CA, Smith GS, Jenkins S, Nathanielsz PW,. Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol 2002; 186: 812-7.
6. Padbury JF, Polk DH, Ervin MG, Berry LM, Ikegami M, Jobe AH,. Postnatal cardiovascular and metabolic responses to a single intramuscular dose of betamethasone in fetal sheep born prematurely by cesarean section. Pediatr Res 1995; 38: 709-15.
7. Bal MP, de Vries WB, van der Leij FR, van Oosterhout MF, Berger RM, Baan J, et al., Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilation in early life: studies in 4-week-old prepubertal rats. Pediatr Res 2005; 58: 46-52.
8. Docherty CC, Kalmar-Nagy J, Engelen M, Koenen SV, Nijland M, Kuc RE, et al., Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1. Am J Physiol Regul Integr Comp Physiol 2001; 281: R261-8.
9. Segar JL, Bedell KA, Smith OJ,. Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II. Am J Physiol Regul Integr Comp Physiol 2001; 280: R646-54.
10. Jobe AH, Wada N, Berry LM, Ikegami M, Ervin MG,. Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol 1998; 178: 880-5.
11. Jellyman JK, Gardner DS, Edwards CM, Fowden AL, Giussani DA,. Fetal cardiovascular, metabolic and endocrine responses to acute hypoxaemia during and following maternal treatment with dexamethasone in sheep. J Physiol 2005; 567: 673-88.
12. Karemaker R, Karemaker JM, Kavelaars A, Tersteeg-Kamperman M, Baerts W, Veen S, et al., Effects of neonatal dexamethasone treatment on the cardiovascular stress response of children at school age. Pediatrics 2008; 122: 978-87.
13. Lackman F, Capewell V, Richardson B, daSilva O, Gagnon R,. The risks of spontaneous preterm delivery and perinatal mortality in relation to size at birth according to fetal versus neonatal growth standards. Am J Obstet Gynecol 2001; 184: 946-53.
14. Crispi F, Bijnens B, Figueras F, Bartrons J, Eixarch E, Le Noble F, et al., Fetal growth restriction results in remodeled and less efficient hearts in children. Circulation 2010; 121: 2427-36.
15. Bahtiyar MO, Copel JA,. Cardiac changes in the intrauterine growth-restricted fetus. Sem Perinat 2008; 32: 190-3.
16. Severi FM, Rizzo G, Bocchi C, D'Antona D, Verzuri MS, Arduini D,. Intrauterine growth retardation and fetal cardiac function. Fetal Diagn Ther 2000; 15: 8-19.
17. Kiserud T, Ebbing C, Kessler J, Rasmussen S,. Fetal cardiac output, distribution to the placenta and impact of placental compromise. Ultrasound Obstet Gynecol 2006; 28: 126-36.
18. Poston L,. Influences of maternal nutritional status on vascular function in the offspring. Curr Drug Targets 2007; 8: 914-22.
19. Xu Y, Williams SJ, O'Brien D, Davidge ST,. Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring. FASEB J 2006; 20: 1251-3.
20. Norman M,. Low birth weight and the developing vascular tree: a systematic review. Acta Paediatr 2008; 97: 1165-72.
21. Li G, Xiao Y, Estrella JL, Ducsay CA, Gilbert RD, Zhang L,. Effect of fetal hypoxia on heart susceptibility to ischemia and reperfusion injury in the adult rat. J Soc Gynecol Invest 2003; 10: 265-74.
22. Miller SL, Supramaniam VG, Jenkin G, Walker DW, Wallace EM,. Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus. Am J Obstet Gynecol 2009; 201: 613 e1-8.
23. Fletcher AJ, Forhead AJ, Fowden AL, Ford WR, Nathanielsz PW, Giussani DA,. Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation. J Physiol 2005; 562: 493-505.
24. Supramaniam VG, Jenkin G, Loose J, Wallace EM, Miller SL,. Chronic fetal hypoxia increases activin A concentrations in the late-pregnant sheep. BJOG 2006; 113: 102-9.
25. Burrell JH, Boyn AM, Kumarasamy V, Hsieh A, Head SI, Lumbers ER,. Growth and maturation of cardiac myocytes in fetal sheep in the second half of gestation. Anat Record 2003; 274: 952-61.
26. Mayhew TM, Pharaoh A, Austin A, Fagan DG,. Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical disectors. J Anat 1997; 191: 107-15.
27. Louey S, Jonker SS, Giraud GD, Thornburg KL,. Placental insufficiency decreases cell cycle activity and terminal maturation in fetal sheep cardiomyocytes. J Physiol 2007; 580: 639-48.
28. Morrison JL, Botting KJ, Dyer JL, Williams SJ, Thornburg KL, McMillen IC,. Restriction of placental function alters heart development in the sheep fetus. Am J Physiol Regul Integr Comp Physiol 2007; 293: R306-13.
29. Bubb KJ, Cock ML, Black MJ, Dodic M, Boon WM, Parkington HC, et al., Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep. J Physiol 2007; 578: 871-81.
30. Veille JC, Hanson R, Sivakoff M, Hoen H, Ben-Ami M,. Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol 1993; 10: 275-9.
31. Jensen A, Roman C, Rudolph AM,. Effects of reducing uterine blood flow on fetal blood flow distribution and oxygen delivery. J Dev Physiol 1991; 15: 309-23.
32. Shan J, Yu XC, Fung ML, Wong TM,. Attenuated 'cross talk' between kappa-opioid receptors and beta-adrenoceptors in the heart of chronically hypoxic rats. Pflugers Archiv 2002; 444: 126-32.
33. Ostadal B, Kolar F,. Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects. Respir Physiol Neurobiol 2007; 158: 224-36.
34. Benavides-Serralde A, Scheier M, Cruz-Martinez R, Crispi F, Figueras F, Gratacos E, et al., Changes in central and peripheral circulation in intrauterine growth-restricted fetuses at different stages of umbilical artery flow deterioration: new fetal cardiac and brain parameters. Gynecol Obstet Invest 2011; 71: 274-80.
35. Duffy JY, Nelson DP, Schwartz SM, Wagner CJ, Bauer SM, Lyons JM, et al., Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets. Pediatr Crit Care Med 2004; 5: 28-34.
36. Rossier MF, Python M, Maturana AD,. Contribution of mineralocorticoid and glucocorticoid receptors to the chronotropic and hypertrophic actions of aldosterone in neonatal rat ventricular myocytes. Endocrinology 2010; 151: 2777-87.
37. Kaljusto ML, Stenslokken KO, Mori T, Panchenko A, Frantzen ML, Valen G, et al., Preconditioning effects of steroids and hyperoxia on cardiac ischemia-reperfusion injury and vascular reactivity. Eur J Cardiothorac Surg 2008; 33: 355-63.
38. Clifton VL, Wallace EM, Smith R,. Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro. J Clin Endocrinol Metab 2002; 87: 2838-42.
39. Edwards A, Baker LS, Wallace EM,. Changes in fetoplacental vessel flow velocity waveforms following maternal administration of betamethasone. Ultrasound Obstet Gynecol 2002; 20: 240-4.
40. Molnar J, Nijland MJ, Howe DC, Nathanielsz PW,. Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep. Am J Physiol Regul Integr Comp Physiol 2002; 283: R561-7.
41. Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE,. Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. Am J Physiol 1998; 274: R160-7.
42. Felszeghy K, Bagdy G, Nyakas C,. Blunted pituitary-adrenocortical stress response in adult rats following neonatal dexamethasone treatment. J Neuroendocrinol 2000; 12: 1014-21.
43. Bian XP, Seidler FJ, Bartolome J, Kavlock RJ, Bartolome M, Slotkin TA,. Dose-dependent effect of prenatal dexamethasone treatment on beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic AMP. J Dev Physiol 1990; 14: 125-30.
44. Esler M,. The 2009 Carl Ludwig Lecture: Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. J Appl Physiol 2010; 108: 227-37.
45. de Vries WB, Karemaker R, Mooy NF, Strengers JL, Kemperman H, Baerts W, et al., Cardiovascular follow-up at school age after perinatal glucocorticoid exposure in prematurely born children: perinatal glucocorticoid therapy and cardiovascular follow-up. Arch Pediatr Adolesc Med 2008; 162: 738-44.
46. Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, et al., Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 2005; 365: 1856-62.