Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets

Pediatric Critical Care Medicine

Volumn 5, Issue 1, 2004, Pages 28-34

  Duffy, Jodie Y ^a,b   Nelson, David P ^a,b   Schwartz, Steven M ^a,b   Wagner, Connie J ^a   Bauer, Steven M ^a   Lyons, Jefferson M ^a,b   McNamara, Jerri L ^a   Pearl, Jeffrey M ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiopulmonary bypass; Cytokines; Glucocorticoids; Ischemia; Reperfusion; Ventricular function

Indexed keywords

CYTOKINE; GLUCOCORTICOID;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BLOOD; CARDIOPULMONARY BYPASS; EVALUATION; HEART FUNCTION TEST; METHODOLOGY; PATHOLOGY; PEROPERATIVE CARE; PREOPERATIVE CARE; RANDOMIZATION; REPERFUSION INJURY; SWINE;

ANALYSIS OF VARIANCE; ANIMALS; CARDIOPULMONARY BYPASS; CYTOKINES; GLUCOCORTICOIDS; HEART FUNCTION TESTS; INTRAOPERATIVE CARE; MYOCARDIAL REPERFUSION INJURY; PREOPERATIVE CARE; RANDOM ALLOCATION; SWINE;

EID: 2142714026     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/01.PCC.0000102382.92024.04     Document Type: Article

References (33)

1. Drinkwater DC, Cushen CK, Laks H, et al: The use of combined antegrade-retrograde infusion of blood cardioplegic solution in pediatric patients undergoing heart operations. J Thorac Cardiovasc Surg 1992; 104: 1349-1355
2. Tarnok A, Hambsch J, Emmrich F, et al: Complement activation, cytokines, and adhesion molecules in children undergoing cardiac surgery with or without cardiopulmonary bypass. Pediatr Cardiol 1999; 20: 113-125
3. Brix-Christensen V, Chew M: The cytokine response after cardiac surgery with cardiopulmonary bypass. Mod Asp Immunobiol 2001; 1:264-266
4. Hill GE, Alonso A, Spurzem JR, et al: Glucocorticoids blunt neutrophil CD11b surface glycoprotein upregulation during cardiopulmonary bypass in humans. Anesth Analg 1994; 79:23-27
5. Dernek S, Tunerir B, Sevin B, et al: The effects of methylprednisolone on complement, immunoglobulins and pulmonary neutrophil sequestration during cardiopulmonary bypass. Cardiovasc Surg 1999; 7:414-418
6. Julia P, Kofsky E, Buckberg GD, et al: Studies of myocardial protection in the immature heart: IV. Models of ischemic and hypoxic/ ischemic injury in the immature puppy heart. J Thorac Cardiovasc Surg 1991; 101: 14-22
7. Kofsky E, Julia P, Buckberg GD, et al: Studies of myocardial protection in the immature heart. V. Safety of prolonged aortic clamping with hypocalcemic glutamate/aspartate blood cardioplegia. J Thorac Cardiovasc Surg 1991; 101:33-43
8. Ihnken K: Myocardial protection in hypoxic immature hearts. Thorac Cardiovasc Surg 2000; 48:46-54
9. Serraf A, Robotin M, Bonnet N, et al: Alteration of the neonatal pulmonary physiology after total cardiopulmonary bypass. J Thorac Cardiovasc Surg 1997; 114: 1061-1069
10. Pearl JM, Wellmann SA, McNamara JL, et al: Bosentan prevents hypoxia-reoxygenationinduced pulmonary hypertension and improves pulmonary function. Ann Thorac Surg 1999; 68:1714-1722
11. Misawa Y, Kawahito K, Konishi H, et al: Cytokine mediated endothelial activation during and after normothermic cardiopulmonary bypass: Heparin-bonded versus non heparin-bonded circuits. ASAIO J 2000; 46: 740-743
12. Yilmaz M, Ener S, Akalin H, et al: Effect of low-dose methyl prednisolone on serum cytokine levels following extracorporeal circulation. Perfusion 1999; 14:201-206
13. Brix-Christensen V, Peterson TK, Ravn HB, et al: Cardiopulmonary bypass elicits a proand anti-inflammatory cytokine response and impaired neutrophil chemotaxis in neonatal pigs. Acta Anaesthesiol Scand 2001; 45:407-413
14. Burns SA, Newburger JW, Xiao M, et al: Induction of interleukin-8 messenger RNA in heart and skeletal muscle during pediatric cardiopulmonary bypass. Circulation 1995; 92:II315-II321
15. Duval EL, Kavelaars A, Veenhuizen L, et al: Pro- and anti-inflammatory cytokine patterns during and after cardiac surgery in young children. Eur J Pediatr 1999; 158: 387-393
16. Hornstein PS, Zuagg CE, Zhu P, et al: Combined blockade of endothelin-1 and thromboxane A2 receptors against postischemic contractile dysfunction in rat hearts. Br J Pharmacol 2001; 132:234-240
17. Journois D, Israel-Biet D, Pouard P, et al: High-volume, zero-balanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children. Anesthesiology 1996; 85:965-976
18. Ashraf S, Tian Y, Cowan D, et al: Release of proinflammatory cytokines during pediatric cardiopulmonary bypass: Heparin bonded versus nonbonded oxygenators. Ann Thorac Surg 1997; 64:1790-1794
19. Olsson C, Siegbahn A, Henze A, et al: Heparin- coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery. Scand Cardiovasc J 2000; 34: 33-40
20. Checchia PA, Backer CL, Bronicki RA, et al: Glucocorticoid treatment decreases myocardial injury as measured by troponin release in children undergoing cardiopulmonary bypass. Circulation 1998; 98:I-547
21. Bronicki RA, Backer CL, Baden HP, et al: Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children. Ann Thorac Surg 2000; 69: 1490-1495
22. Varan B, Tokel K, Mercan S, et al: Systemic inflammatory response related to cardiopulmonary bypass and its modification by methyl prednisolone: High dose versus low dose. Pediatr Cardiol 2002; 23: 437-441
23. Schroeder VA, Pearl JM, Schwartz SM, et al: Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression. Circulation 2003; 107:2823-2828
24. Lodge AJ, Chai PJ, Daggett CW, et al: Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: Timing of dose is important. J Thorac Cardiovasc Surg 1999; 117: 515-522
25. U.S. National Institutes of Health: Guide for the Care and Use of Laboratory Animals (NIH Publication No. 86-23). Bethesda, MD, National Institutes of Health, 1996
26. Pearl JM, Nelson DP, Schwartz SM, et al: Glucocorticoids reduce ischemia-reperfusion- induced myocardial apoptosis in immature hearts. Ann Thorac Surg 2002; 74: 830-837
27. Wan S, DeSmet J-M, Antoine M, et al: Steroid administration in heart and heart-lung transplantation: Is the timing adequate? Ann Thorac Surg 1996; 61:674-678
28. Hayward R, Nossuli TO, Scalia R, et al: Cardioprotective effect of interleukin-10 in murine myocardial ischemia-reperfusion. Eur J Pharmacol 1997; 334:157-163
29. Yang Z, Zingarelli B, Szabó C: Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 2000; 101:1019-1026
30. Wan S, LeClerc JL, Schmartz D, et al: Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients. Am Heart J 1997; 133: 335-339
31. Frangogiannis NG, Mendoza LH, Lindsey ML, et al: IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury. J Immunol 2000; 165: 2798-2808
32. Berrebi D, Bruscoli S, Cohen N, et al: Synthesis of glucocorticoid- induced leucine zipper (GILZ) by macrophages: An anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. Blood 2002; 101:729-738
33. Brix-Christensen V, Vestergaard C, Chew M, et al: Plasma cytokines do not reflect expression of pro- and anti-inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal piglets. Acta Anaesthesiol Scand 2003; 47:525-531