Norisoboldine inhibits the production of interleukin-6 in fibroblast-like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF-κB-p65/CREB pathways

Journal of Cellular Biochemistry

Volumn 113, Issue 8, 2012, Pages 2785-2795

  Wei, Zhifeng ^a   Wang, Fengyun ^a   Song, Jie ^a   Lu, Qian ^a   Zhao, Peng ^a   Xia, Yufeng ^a   Chou, Guixin ^b   Wang, Zhengtao ^b   Dai, Yue ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Fibroblast like synoviocytes; Interleukin 6; Norisoboldine; Rheumatoid arthritis; Signal pathways

Indexed keywords

ANTIRHEUMATIC AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOQUINOLINE ALKALOID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NORISOBOLDINE; PROTEIN KINASE C; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; DISEASE COURSE; DOWN REGULATION; DRUG STRUCTURE; EFFECTOR CELL; ENZYME PHOSPHORYLATION; FIBROBLAST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNOVIOCYTE;

ALKALOIDS; ANIMALS; ARTHRITIS, RHEUMATOID; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FIBROBLASTS; INTERLEUKIN-6; NF-KAPPA B; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE;

EID: 84862526774     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24156     Document Type: Article

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