Islet isolation and purification from inbred Wuzhishan miniature pigs

Xenotransplantation

Volumn 19, Issue 3, 2012, Pages 159-165

  Jiang, Xiaofeng ^a   Qian, Taolai ^b   Linn, Thomas ^c   Cao, Liangqi ^a   Xiang, Guangyang ^a   Wang, Yezeng ^a   Peng, Heping ^a   Xue, Ping ^a   Zhang, Lehong ^a   Chen, De ^a   Yang, Xuewei ^a  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b China   (China)

^c UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Islet; Isolation; Miniature pig; Purification

Indexed keywords

ANATOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; INBRED STRAIN; ISOLATED PANCREAS ISLET; MALE; MINIPIG; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PURIFICATION; TREATMENT OUTCOME; WUZHISHAN MINIATURE PIG; XENOTRANSPLANTATION;

ANIMALS; BREEDING; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LIVER; MALE; ORGAN CULTURE TECHNIQUES; ORGAN SIZE; SPECIES SPECIFICITY; SUS SCROFA; SWINE; SWINE, MINIATURE; TISSUE AND ORGAN HARVESTING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84862526043     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2012.00702.x     Document Type: Article

References (8)

1. THOMPSON P, CARDONA K, RUSSELL M et al. CD40- specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates. Am J Transplant 2011; 11: 947-957.
2. VAN DER WINDT DJ, BOTTINO R, CASU A et al. Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transplant 2009; 9: 2716-2726.
3. HERING BJ, WIJKSTROM M, GRAHAM ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303.
4. KIM JH, KIM HI, LEE KW. Influence of strain and age differences on the yields of porcine islet isolation: extremely high islet yields from SPF CMS miniature pigs. Xenotransplantation 2007; 14: 60-66.
5. KIM HI, LEE SY, JIN SM et al. Parameters for successful pig islet isolation as determined using 68 specific-pathogen-free miniature pigs. Xenotransplantation 2009; 16: 11-18.
6. FERRER J, SCOTT WE III, WEEGMAN BP et al. Pig pancreas anatomy: implications for pancreas procurement, preservation, and islet isolation. Transplantation 2008; 86: 1503-1510.
7. RIZZARI MD, SUSZYNSKI TM, KIDDER LS et al. Surgical protocol involving the infusion of paramagnetic microparticles for preferential incorporation within porcine islets. Transplant Proc 2010; 42: 4209-4212.
8. DUFRANE D, D'HOORE W, GOEBBELS RM et al. Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-to-primate models. Xenotransplantation 2006; 13: 204-214.