Influence of strain and age differences on the yields of porcine islet isolation: Extremely high islet yields from SPF CMS miniature pigs

Xenotransplantation

Volumn 14, Issue 1, 2007, Pages 60-66

  Kim, Jae Hyeon ^a,b,c   Kim, Hyoung Il ^b,c   Lee, Kang Woo ^b,c   Yu, Jae Eun ^b,c   Kim, Sun Hee ^b,c   Park, Ho Sun ^b   Park, Chung Gyu ^b,c,d   Ihm, Sung Hee ^e   Ha, Jongwon ^b,d   Kim, Sang Joon ^b,d   Lee, Hong Kyu ^d   Ahn, Curie ^b,c,d   Park, Kyong Soo ^b,c,d  

^a Seoul National University Boramae Hospital   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Hallym University   (South Korea)

Author keywords

Breed; Chicago Medical School miniature pig; Porcine islet isolation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; FEMALE; GERMFREE ANIMAL; IN VITRO STUDY; IN VIVO STUDY; ISOLATION PROCEDURE; MALE; MINIPIG; NONHUMAN; ORGAN DONOR; ORGAN SIZE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SLAUGHTERHOUSE; SPECIES COMPARISON; SWINE; XENOTRANSPLANTATION;

AGING; ANIMALS; ANIMALS, INBRED STRAINS; CELL SEPARATION; FEMALE; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; ORGAN SIZE; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE; SWINE, MINIATURE;

EID: 33845988773     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00364.x     Document Type: Article

References (26)

1. KORSGREN O, BUHLER LH, GROTH CG. Toward clinical trials of islet xenotransplantation. Xenotransplantation 2003; 10: 289-292.
2. HERING BJ, WIJKSTROM M, GRAHAM ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006; 12: 301-303.
3. TOSO C, BRANDHORST D, OBERHOLZER J et al. Isolation of adult porcine islets of Langerhans. Cell Transplant 2000; 9: 297-305.
4. DUFRANE D, GOEBBELS RM, FDILAT I et al. Impact of porcine islet size on cellular structure and engraftment after transplantation: adult vs. young pigs. Pancreas 2005; 30: 138-147.
5. KRICKHAHN M, BUHLER C, MEYER T et al. The morphology of islets within the porcine donor pancreas determines the isolation result: successful isolation of pancreatic islets can now be achieved from young market pigs. Cell Transplant 2002; 11: 827-838.
6. KIRCHHOF N, HERING BJ, GEISS V et al. Evidence for breed-dependent differences in porcine islets of Langerhans. Transplant Proc 1994; 26: 616-617.
7. O'NEIL JJ, STEGEMANN JP, NICHOLSON DT et al. The isolation and function of porcine islets from market weight pigs. Cell Transplant 2001; 10: 235-246.
8. BRANDHORST H, BRANDHORST D, HERING BJ, BRETZEL RG. Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion. Transplantation 1999; 68: 355-361.
9. GOUIN E, RIVEREAU AS, DARQUY S et al. Minimisation of microbial contamination for potential islet xenografts using specific pathogen-free pigs and a protected environment during tissue preparation. Diabetes Metab 1997; 23: 537-540.
10. TUCKER A, BELCHER C, MOLOO B et al. The production of transgenic pigs for potential use in clinical xenotransplantation: baseline clinical pathology and organ size studies. Xenotransplantation 2002; 9: 203-208.
11. SETCAVAGE TM, KIM YB. Variability of the immunological state of germfree colostrum-deprived Minnesota miniature piglets. Infect Immun 1976; 13: 600-607.
12. VAN DER BURG MP, BASIR I, BOUWMAN E. No porcine islet loss during density gradient purification in a novel iodixanol in University of Wisconsin solution. Transplant Proc 1998; 30: 362-363.
13. WEIBER ER. Volume density measurement: the principle of Delesse. In: WEIBER ER, ed. Stereological Methods, Vol 1. Practical Methods for Biological Morphometry. London: Academic Press, 1979: 51.
14. BRANDHORST D, IKEN M, TANIOKA Y et al. Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation. Transplantation 2005; 79: 38-43.
15. BRANDHORST D, IKEN M, BRENDEL MD et al. Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation. Transplantation 2005; 79: 433-437.
16. KIRCHHOF N, SHIBATA S, WIJKSTROM M et al. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 2004; 11: 396-407.
17. GOTO M, MAEDA A, ELFMAN L et al. No transmission of porcine endogenous retrovirus after transplantation of adult porcine islets into diabetic nude mice and immunosuppressed rats. Xenotransplantation 2004; 11: 340-346.
18. WENNBERG L, SONG Z, BENNET W et al. Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days. Transplantation 2001; 71: 1024-1033.
19. DAVALLI AM, OGAWA Y, SCAGLIA L et al. Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 1995; 44: 104-111.
20. WHITE SA, HUGHES DP, CONTRACTOR HH, LONDON NJ. A comparison of cross sectional surface area densities between adult and juvenile porcine islets of Langerhans. Horm Metab Res 1999; 31: 519-524.
21. JAY TR, HEALD KA, CARLESS NJ et al. The distribution of porcine pancreatic beta-cells at ages 5, 12 and 24 weeks. Xenotransplantation 1999; 6: 131-140.
22. DUFRANE D, D'HOORE W, GOEBBELS RM et al. Parameters favouring successful adult pig islet isolations for xenotransplantation in pig-to-primate models. Xenotransplantation 2006; 13: 204-214.
23. MATSUMOTO I, SAWADA T, NAKANO M et al. Improvement in islet yield from obese donors for human islet transplants. Transplantation 2004; 78: 880-885.
24. BRANDHORST D, HERING BJ, BRANDHORST H et al. Body mass index is an important determinant for human islet isolation outcome. Transplant Proc 1994; 26: 3529-3530.
25. LARSEN MO, JUHL CB, PORKSEN N et al. Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Gottingen minipigs. Am J Physiol Endocrinol Metab 2005; 288: E412-E421.
26. HUBERT T, JANY T, MARCELLI-T OURVIEILLE S et al. Acute insulin response of donors is correlated with pancreatic islet isolation outcome in the pig. Diabetologia 2005; 48: 2069-2073.