메뉴 건너뛰기




Volumn 33, Issue 6, 2012, Pages 817-822

E-cadherin promotes proliferation of human ovarian cancer cells in vitro via activating MEK/ERK pathway

Author keywords

E cadherin; extracellular signal related kinase (ERK); mitogen activated protein kinase kinase (MEK); ovarian cancer; proliferation; RNA interference

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; UVOMORULIN; WORTMANNIN;

EID: 84862524124     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.30     Document Type: Article
Times cited : (33)

References (32)
  • 1
    • 0029088312 scopus 로고
    • Retinoic acid modulates epidermal growth factor receptor expression in human lung epithelial cancer cells
    • Fang K, Mukhopadhyay T, Shih SH. Retinoic acid modulates epidermal growth factor receptor expression in human lung epithelial cancer cells. J Biomed Sci 1995; 2: 256-62.
    • (1995) J. Biomed. Sci. , vol.2 , pp. 256-262
    • Fang, K.1    Mukhopadhyay, T.2    Shih, S.H.3
  • 2
    • 0027185632 scopus 로고
    • From cadherins to catenins: Cytoplasmic protein interactions and regulation of cell adhesion
    • Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 1993; 9: 317-21.
    • (1993) Trends Genet , vol.9 , pp. 317-321
    • Kemler, R.1
  • 3
    • 0025894092 scopus 로고
    • Cadherin cell adhesion receptors as a morphogenetic regulator
    • Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451-5.
    • (1991) Science , vol.251 , pp. 1451-1455
    • Takeichi, M.1
  • 4
    • 0030000980 scopus 로고    scopus 로고
    • Cadherin-Catenin complex: Protein interactions and their implications for cadherin function
    • Aberle H, Schwartz H, Kemler R. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 1996; 61: 514-23.
    • (1996) J. Cell Biochem. , vol.61 , pp. 514-523
    • Aberle, H.1    Schwartz, H.2    Kemler, R.3
  • 5
    • 0035947772 scopus 로고    scopus 로고
    • E-Cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesionindependent manner
    • Gottardi CJ, Wong E, Gumbiner BM. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesionindependent manner. J Cell Biol 2001; 153: 1049-60.
    • (2001) J. Cell Biol. , vol.153 , pp. 1049-1060
    • Gottardi, C.J.1    Wong, E.2    Gumbiner, B.M.3
  • 6
    • 0027645907 scopus 로고
    • Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas
    • Birchmeier W, Weidner KM, Hulsken J, Behrens J. Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol 1993; 4: 231-9.
    • (1993) Semin. Cancer Biol. , vol.4 , pp. 231-239
    • Birchmeier, W.1    Weidner, K.M.2    Hulsken, J.3    Behrens, J.4
  • 7
    • 0029240438 scopus 로고
    • E-cadherin as a tumor (invasion) suppressor gene
    • Birchmeier W. E-cadherin as a tumor (invasion) suppressor gene. Bioessays 1995; 17: 97-9.
    • (1995) Bioessays , vol.17 , pp. 97-99
    • Birchmeier, W.1
  • 8
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
    • Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198: 11-26.
    • (1994) Biochim. Biophys Acta. , vol.1198 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 9
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 11
    • 0141526076 scopus 로고    scopus 로고
    • Connecting estrogen receptor function, transcriptional repression, and E-Cadherin expression in breast cancer
    • Fearon ER. Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer. Cancer Cell 2003; 3: 307-10.
    • (2003) Cancer Cell , vol.3 , pp. 307-310
    • Fearon, E.R.1
  • 12
    • 0032479321 scopus 로고    scopus 로고
    • E-Cadherin regulates anchorage-Independent growth and survival in oral squamous cell carcinoma cells
    • Kantak SS, Kramer RH. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem 1998; 273: 16953-61.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16953-16961
    • Kantak, S.S.1    Kramer, R.H.2
  • 13
    • 0030898075 scopus 로고    scopus 로고
    • Expression of the E-Cadherin-Catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases
    • Andrews NA, Jones AS, Helliwell TR, Kinsella AR. Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer 1997; 75: 1474-80.
    • (1997) Br. J. Cancer , vol.75 , pp. 1474-1480
    • Andrews, N.A.1    Jones, A.S.2    Helliwell, T.R.3    Kinsella, A.R.4
  • 15
    • 0031002444 scopus 로고    scopus 로고
    • Increased E-cadherin expression in ovarian surface epithelium: An early step in metaplasia and dysplasia
    • Maines-Bandiera SL, Auersperg N. Increased E-cadherin expression in ovarian surface epithelium: An early step in metaplasia and dysplasia. Int J Gynecol Pathol 1997; 16: 250-5.
    • (1997) Int. J. Gynecol. Pathol. , vol.16 , pp. 250-255
    • Maines-Bandiera, S.L.1    Auersperg, N.2
  • 16
    • 0030761757 scopus 로고    scopus 로고
    • Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases
    • Darai E, Scoazec JY, Walker-Combrouze F, Mlika-Cabanne N, Feldmann G, Madelenat P, et al. Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases. Hum Pathol 1997; 28: 922-8.
    • (1997) Hum. Pathol. , vol.28 , pp. 922-928
    • Darai, E.1    Scoazec, J.Y.2    Walker-Combrouze, F.3    Mlika-Cabanne, N.4    Feldmann, G.5    Madelenat, P.6
  • 17
    • 25444448222 scopus 로고    scopus 로고
    • Formation of E-Cadherin-Mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligandindependent activation of epidermal growth factor receptor in ovarian cancer cells
    • Reddy P, Liu L, Ren C, Lindgren P, Boman K, Shen Y, et al. Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligandindependent activation of epidermal growth factor receptor in ovarian cancer cells. Mol Endocrinol 2005; 19: 2564-78.
    • (2005) Mol. Endocrinol. , vol.19 , pp. 2564-2578
    • Reddy, P.1    Liu, L.2    Ren, C.3    Lindgren, P.4    Boman, K.5    Shen, Y.6
  • 19
    • 0033989195 scopus 로고    scopus 로고
    • An ovarian adenocarcinoma line derived from SV40/E-cadherin-Transfected normal human ovarian surface epithelium
    • Ong A, Maines-Bandiera SL, Roskelley CD, Auersperg N. An ovarian adenocarcinoma line derived from SV40/E-cadherin-transfected normal human ovarian surface epithelium. Int J Cancer 2000; 85: 430-7.
    • (2000) Int. J. Cancer , vol.85 , pp. 430-437
    • Ong, A.1    Maines-Bandiera, S.L.2    Roskelley, C.D.3    Auersperg, N.4
  • 20
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via beta-Catenin-Egr1-mediated PTEN expression
    • Lau MT, Klausen C, Leung PC. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via beta-catenin-Egr1-mediated PTEN expression. Oncogene 2011; 30: 2753-66.
    • (2011) Oncogene. , vol.30 , pp. 2753-2766
    • Lau, M.T.1    Klausen, C.2    Leung, P.C.3
  • 21
    • 0034994490 scopus 로고    scopus 로고
    • Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cellcell adhesion sites
    • Nakagawa M, Fukata M, Yamaga M, Itoh N, Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cellcell adhesion sites. J Cell Sci 2001; 114: 1829-38.
    • (2001) J. Cll Sci. , vol.114 , pp. 1829-1838
    • Nakagawa, M.1    Fukata, M.2    Yamaga, M.3    Itoh, N.4    Kaibuchi, K.5
  • 22
    • 62049085785 scopus 로고    scopus 로고
    • E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-P85 regulatory subunit to adherens junctions of ovarian carcinoma cells
    • De Santis G, Miotti S, Mazzi M, Canevari S, Tomassetti A. E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells. Oncogene 2009; 28: 1206-17.
    • (2009) Oncogene. , vol.28 , pp. 1206-1217
    • De Santis, G.1    Miotti, S.2    Mazzi, M.3    Canevari, S.4    Tomassetti, A.5
  • 23
    • 0026628145 scopus 로고
    • Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs
    • Inoue M, Ogawa H, Miyata M, Shiozaki H, Tanizawa O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am J Clin Pathol 1992; 98: 76-80.
    • (1992) Am. J. Clin. Pathol. , vol.98 , pp. 76-80
    • Inoue, M.1    Ogawa, H.2    Miyata, M.3    Shiozaki, H.4    Tanizawa, O.5
  • 24
    • 0028021979 scopus 로고
    • Differential expression of the cell-Cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
    • Veatch AL, Carson LF, Ramakrishnan S. Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells. Int J Cancer 1994; 58: 393-9.
    • (1994) Int. J. Cancer , vol.58 , pp. 393-399
    • Veatch, A.L.1    Carson, L.F.2    Ramakrishnan, S.3
  • 25
    • 0031889636 scopus 로고    scopus 로고
    • Expression of E-cadherin, alphacatenin and beta-catenin in normal ovarian surface epithelium and epithelial ovarian cancers
    • Davies BR, Worsley SD, Ponder BA. Expression of E-cadherin, alphacatenin and beta-catenin in normal ovarian surface epithelium and epithelial ovarian cancers. Histopathology 1998; 32: 69-80.
    • (1998) Histopathology , vol.32 , pp. 69-80
    • Davies, B.R.1    Worsley, S.D.2    Ponder, B.A.3
  • 26
    • 5644288503 scopus 로고    scopus 로고
    • Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes
    • Fouquet S, Lugo-Martinez VH, Faussat AM, Renaud F, Cardot P, Chambaz J, et al. Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes. J Biol Chem 2004; 279: 43061-9.
    • (2004) J. Biol. Chem. , vol.279 , pp. 43061-43069
    • Fouquet, S.1    Lugo-Martinez, V.H.2    Faussat, A.M.3    Renaud, F.4    Cardot, P.5    Chambaz, J.6
  • 27
    • 34248221182 scopus 로고    scopus 로고
    • E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase
    • Kang HG, Jenabi JM, Zhang J, Keshelava N, Shimada H, May WA, et al. E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res 2007; 67: 3094-105.
    • (2007) Cancer Res. , vol.67 , pp. 3094-3105
    • Kang, H.G.1    Jenabi, J.M.2    Zhang, J.3    Keshelava, N.4    Shimada, H.5    May, W.A.6
  • 28
    • 77956495728 scopus 로고    scopus 로고
    • Ovarian cancer development and metastasis
    • Lengyel E. Ovarian cancer development and metastasis. Am J Pathol 2010; 177: 1053-64.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1053-1064
    • Lengyel, E.1
  • 29
    • 4644310419 scopus 로고    scopus 로고
    • Adhesion-mediated squamous cell carcinoma survival through ligand-Independent activation of epidermal growth factor receptor
    • Shen X, Kramer RH. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol 2004; 165: 1315-29.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1315-1329
    • Shen, X.1    Kramer, R.H.2
  • 30
    • 54849413963 scopus 로고    scopus 로고
    • ERK activation and nuclear signaling induced by the loss of cell/matrix adhesion stimulates anchorage-Independent growth of ovarian cancer cells
    • Al-Ayoubi A, Tarcsafalvi A, Zheng H, Sakati W, Eblen ST. ERK activation and nuclear signaling induced by the loss of cell/matrix adhesion stimulates anchorage-independent growth of ovarian cancer cells. J Cell Biochem 2008; 105: 875-84.
    • (2008) J. Cell Biochem. , vol.105 , pp. 875-884
    • Al-Ayoubi, A.1    Tarcsafalvi, A.2    Zheng, H.3    Sakati, W.4    Eblen, S.T.5
  • 31
    • 42049107076 scopus 로고    scopus 로고
    • Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target
    • Sawada K, Mitra AK, Radjabi AR, Bhaskar V, Kistner EO, Tretiakova M, et al. Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res 2008; 68: 329-39.
    • (2008) Cancer Res. , vol.68 , pp. 329-339
    • Sawada, K.1    Mitra, A.K.2    Radjabi, A.R.3    Bhaskar, V.4    Kistner, E.O.5    Tretiakova, M.6
  • 32
    • 3242693775 scopus 로고    scopus 로고
    • Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro
    • Green SK, Francia G, Isidoro C, Kerbel RS. Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol Cancer Ther 2004; 3: 149-59.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 149-159
    • Green, S.K.1    Francia, G.2    Isidoro, C.3    Kerbel, R.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.