Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

Apoptosis

Volumn 17, Issue 5, 2012, Pages 503-515

  Ferreira, Karine Sá ^a   Kreutz, Clemens ^a   MacNelly, Sabine ^b   Neubert, Karin ^a   Haber, Angelika ^a   Bogyo, Matthew ^c   Timmer, Jens ^a,d   Borner, Christoph ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bid; Caspase inhibitor; Caspase 3; Caspase 8; Feedback loop; Type I apoptosis; XIAP

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 7; CASPASE 8; FAS ANTIGEN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEEDBACK SYSTEM; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 3; CASPASE 8; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; FAS LIGAND PROTEIN; FEEDBACK, PHYSIOLOGICAL; GENE KNOCKOUT TECHNIQUES; HEPATOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLY(ADP-RIBOSE) POLYMERASES; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84862506438     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0691-0     Document Type: Article

References (46)

1. Meier P, Finch A, Evan G (2000) Apoptosis in development. Nature 407:796-801
2. Kanzler S, Galle PR (2000) Apoptosis and the liver. Semin Canc Biol 10:173-184 (Pubitemid 30611679)
3. Osagawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809 (Pubitemid 23261761)
4. Galle PR, Krammer PH (1998) CD95-induced apoptosis in human liver disease. Semin Liver Dis 18:141-151 (Pubitemid 28224005)
5. Canbay A, Friedman S, Gores GJ (2004) Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39:273-278 (Pubitemid 38222163)
6. Ni R, Tomita Y, Matsuda K, Ichihara A, Ishimura K, Ogasawara J, Nagata S (1994) Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res 215:332-337 (Pubitemid 24381083)
7. Schüngel S, Buitrago-Molina LE, devi Nalapareddy P, LebofskyM, Manns MP, Jaeschke H, Gross A, Vogel A (2009) The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers. Hepatology 50:1558-1566
8. Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886-891 (Pubitemid 29406726)
9. Kaufmann T, Tai L, Ekert PG, Huang DCS, Norris F, Lindemann RK, Johnstone RW, Dixit VM, Strasser A (2007) The BH3-only protein Bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (129):423-433 (Pubitemid 46574974)
10. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME (1998) Two CD95 (APO-1/ Fas) signaling pathways. EMBO J 17:1675-1687 (Pubitemid 28119121)
11. Peter ME, Krammer PH (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10:26-35 (Pubitemid 36511830)
12. Chang DW, Xing Z, Capacio VL, Peter ME, Yang X (2003) Interdimer processing mechanism of procaspase-8 activation. EMBO J 22:4132-4142 (Pubitemid 37021742)
13. Medema JP, Scaffidi C, Kischkel FC, Schevchenko A, Mann M, Krammer PH, Peter ME (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16:2794-2804 (Pubitemid 27226216)
14. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273:2926-2930 (Pubitemid 28133943)
15. Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ (1999) Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while Bcl-xL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 274(2):1156-1163
16. Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH (2007) The CD95 receptor: apoptosis revisited. Cell 129:447-450 (Pubitemid 46660984)
17. Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626-629 (Pubitemid 39006738)
18. Desbarats J, Newell MK (2000) Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6:920-923 (Pubitemid 30644752)
19. Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D (2004) Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 173:2976-2984 (Pubitemid 39142002)
20. Kang TB, Oh GS, Scandella E, Bolinger B, Ludewig B, Kovalenko A, Wallach D (2008) Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol 181:2522-2532
21. Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG (2009) Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res 69(9): 3755-3763
22. Kovalenko A, Kim JC, Kang TB, Raiput A, Bogdanoy K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D (2009) Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 206:2161-2177
23. Keller N, Mares J, Zerbe O, Grütter MG (2009) Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation. Structure 17:438-448
24. Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M (2009) Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95- mediated death or survival. Mol Cell 35:265-279
25. Strasser A, Jost PJ, Nagata S (2009) The many roles of FAS receptor signaling in the immune system. Immunity 30:180-192
26. Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR (2010) Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem 285(22):16632-16642
27. Blanc C, Deveraux QL, Krajewski S, Jänicke RU, Porter AG, Reed JC, Jaggi R, Marti A (2000) Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF- 7 breast cancer cells. Cancer Res 60:4386-4390 (Pubitemid 32103616)
28. Fujita E, Egashira J, Urase K, Kuida K, Momoi T (2001) Caspase- 9 processing by caspase-3 via a feedback amplification loop in vivo. Cell Death Differ 8:335-344 (Pubitemid 32409604)
29. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144(2): 281-292 (Pubitemid 29066031)
30. Van de Craen M, Declercq W, Van den brande I, Fiers W, Vandenabeele P (1999) The proteolytic procaspase activation network: an in vitro analysis. Cell Death Differ 6:1117-1124
31. Eissing T, Conzelmann H, Gilles ED, Allgöwer F, Bullinger E, Scheurich P (2004) Bistability analyses of a caspase activation model for receptor-induced apoptosis. J Biol Chem 279(35): 36892-36897 (Pubitemid 39129038)
32. Angeli D, Ferrell JE, Sontag ED (2004) Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci USA 101(7): 1822-1827 (Pubitemid 38228975)
33. Ferrell JE (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14(2):140-148
34. Legewie S, Blüthgen N, Herzel H (2006) Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. PLoS Comput Biol 2(9):e120
35. Tang D, Lahti JM, Kidd VJ (2000) Caspase-8 activation and Bid cleavage contribute to MCF7 cellular execution in a caspase- 3-dependent manner during staurosporine-mediated apoptosis. J Biol Chem 275(13):9303-9307 (Pubitemid 30185152)
36. Slee EA, Keogh SA, Martin SJ (2000) Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalyzed by caspase-3: a potential feedback loop for amplification of apoptosis- associated mitochondrial cytochrome c release. Cell Death Differ 7:556-565 (Pubitemid 30303611)
37. Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C (2008) Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes. Hepatology 48:1942-1953
38. Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KMB, Salvesen GS, Bogyo M (2006) Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell 23:509-521 (Pubitemid 44205485)
39. Klingmüller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S et al (2006) Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage) 153:433-447 (Pubitemid 44712259)
40. Shimizu M, Fontana A, Takeda Y, Yagita H, Yoshimoto T, Matsuzawa A (1999) Induction of antitumor immunity with Fas/ APO-1 ligand (CD95L)-transfected neuroblastoma Neuro-2a cells. J Immunol 162:7350-7357 (Pubitemid 29277711)
41. Huber W, von Heydebreck A, Sültmann H, Poustka A, Vingron M (2002) Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18(Suppl 1):S96-S104 (Pubitemid 41185642)
42. Pop C, Salvesen GS (2009) Human caspases: activation, specificity, and regulation. J Biol Chem 284(33):21777-21781
43. Würstle ML, Laussmann MA, Rehm M (2010) The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling. J Biol Chem 285(43):33209-33218
44. Eyrisch S. Medina-Franco JL, Helms V (2011) Transient pockets on XIAP-BIR2: toward the characterization of putative binding sites of small-molecules XIAP inhibitors. J Mol Model. doi: 10.1007/s00894-011-1217-y
45. Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DCS, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T (2009) XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 460(20):1035-1039
46. Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnóczky G (2002) Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem 277(7):5651-5659 (Pubitemid 34968620)