Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 8, 2012, Pages 1378-1388

  Miyake, Kotaro ^a   Bekisz, Joseph ^a   Zhao, Tongmao ^a   Clark, Christopher R ^a   Zoon, Kathryn C ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

AIF; Apoptosis; Bak; Bid; IFN ; Mitochondria

Indexed keywords

ALPHA2A INTERFERON; APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; PROTEIN BAK; PROTEIN BID; SMALL INTERFERING RNA;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CYTOSOL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; OLIGOMERIZATION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERFERON-ALPHA; MEMBRANE POTENTIAL, MITOCHONDRIAL; OVARIAN NEOPLASMS; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RNA INTERFERENCE;

EID: 84862506183     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.05.031     Document Type: Article

References (40)

1. Pestka S., Langer J.A., Zoon K.C., Samuel C.E. Interferons and their actions. Annu. Rev. Biochem. 1987, 56:727-777.
2. Takaoka A., Yanai H. Interferon signalling network in innate defence. Cell. Microbiol. 2006, 8:907-922.
3. Maher S.G., Romero-Weaver A.L., Scarzello A.J., Gamero A.M. Interferon: cellular executioner or white knight?. Curr. Med. Chem. 2007, 14:1279-1289.
4. Bach E.A., Aguet M., Schreiber R.D. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 1997, 15:563-591.
5. Baron S., Finbloom J., Horowitz J., Bekisz J., Morrow A., Zhao T., Fey S., Schmeisser H., Balinsky C., Miyake K., Clark C., Zoon K. Near eradication of clinically relevant concentrations of human tumor cells by interferon-activated monocytes in vitro. J. Interferon Cytokine Res. 2011, 7:569-573.
6. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 1998, 67:227-264.
7. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26:239-257.
8. Criollo A., Galluzzi L., Maiuri M.C., Tasdemir E., Lavandero S., Kroemer G. Mitochondrial control of cell death induced by hyperosmotic stress. Apoptosis 2007, 12:3-18.
9. Wajant H. The Fas signaling pathway: more than a paradigm. Science (New York, N.Y.) 2002, 296:1635-1636.
10. Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gomez-Monterrey I., Castedo M., Kroemer G. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 1996, 183:1533-1544.
11. Cregan S.P., Dawson V.L., Slack R.S. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23:2785-2796.
12. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999, 397:441-446.
13. Li H., Zhu H., Xu C.J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998, 94:491-501.
14. Tsuno T., Mejido J., Zhao T., Phillips T., Zoon K.C. Bid is a key factor for eliciting the antiproliferative activity of IFN-alpha mediated by TRAIL. J. Immunother. 2012, 35:23-31.
15. Kim T.H., Zhao Y., Barber M.J., Kuharsky D.K., Yin X.M. Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. J. Biol. Chem. 2000, 275:39474-39481.
16. Wei M.C., Lindsten T., Mootha V.K., Weiler S., Gross A., Ashiya M., Thompson C.B., Korsmeyer S.J. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 2000, 14:2060-2071.
17. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (New York, N.Y.) 2001, 292:727-730.
18. Wang G.Q., Gastman B.R., Wieckowski E., Goldstein L.A., Gambotto A., Kim T.H., Fang B., Rabinovitz A., Yin X.M., Rabinowich H. A role for mitochondrial Bak in apoptotic response to anticancer drugs. J. Biol. Chem. 2001, 276:34307-34317.
19. Balachandran S., Kim C.N., Yeh W.C., Mak T.W., Bhalla K., Barber G.N. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 1998, 17:6888-6902.
20. Balachandran S., Roberts P.C., Kipperman T., Bhalla K.N., Compans R.W., Archer D.R., Barber G.N. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway. J. Virol. 2000, 74:1513-1523.
21. Tsuno T., Mejido J., Zhao T., Schmeisser H., Morrow A., Zoon K.C. IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha. J. Immunother. 2009, 32:803-816.
22. Panaretakis T., Pokrovskaja K., Shoshan M.C., Grander D. Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax. Oncogene 2003, 22:4543-4556.
23. Yanase N., Ohshima K., Ikegami H., Mizuguchi J. Cytochrome c release, mitochondrial membrane depolarization, caspase-3 activation, and Bax-alpha cleavage during IFN-alpha-induced apoptosis in Daudi B lymphoma cells. J. Interferon Cytokine Res. 2000, 20:1121-1129.
24. Chawla-Sarkar M., Leaman D.W., Jacobs B.S., Borden E.C. IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis. J. Immunol. 2002, 169:847-855.
25. Thyrell L., Erickson S., Zhivotovsky B., Pokrovskaja K., Sangfelt O., Castro J., Einhorn S., Grander D. Mechanisms of interferon-alpha induced apoptosis in malignant cells. Oncogene 2002, 21:1251-1262.
26. Miyake K., Shimada M., Nishioka M., Sugimoto K., Batmunkh E., Uto Y., Nagasawa H., Hori H. The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer. Cancer Lett. 2008, 272:325-335.
27. Becattini B., Sareth S., Zhai D., Crowell K.J., Leone M., Reed J.C., Pellecchia M. Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. Chem. Biol. 2004, 11:1107-1117.
28. Lademann U., Cain K., Gyrd-Hansen M., Brown D., Peters D., Jaattela M. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol. Cell. Biol. 2003, 23:7829-7837.
29. Strander H., Einhorn S. Interferons and the tumor cell. Biotherapy (Dordrecht, Netherlands) 1996, 8:213-218.
30. Sangfelt O., Erickson S., Castro J., Heiden T., Einhorn S., Grander D. Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines. Cell Growth Differ. 1997, 8:343-352.
31. Miyake K., Imura S., Nishioka M., Batmunkh E., Sugimoto K., Ohmoto Y., Shimada M. Serum evaluation of soluble interferon-alpha/beta receptor and high-sensitivity C-reactive protein for diagnosis of the patients with gastrointestinal and hepatobiliary-pancreatic cancer. Cytokine 2010, 49:251-255.
32. Smalley R.V., Weller E., Hawkins M.J., Oken M.M., O'Connell M.J., Haase-Statz S., Borden E.C. Final analysis of the ECOG I-COPA trial (E6484) in patients with non-Hodgkin's lymphoma treated with interferon alfa (IFN-alpha2a) plus an anthracycline-based induction regimen. Leukemia 2001, 15:1118-1122.
33. Miyake K., Tsuchida K., Sugino H., Imura S., Morine Y., Fujii M., Shimada M. Combination therapy of human pancreatic cancer implanted in nude mice by oral fluoropyrimidine anticancer agent (S-1) with interferon-alpha. Cancer Chemother. Pharmacol. 2007, 59:113-126.
34. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
35. Martinou J.C., Green D.R. Breaking the mitochondrial barrier. Nat. Rev. Mol. Cell Biol. 2001, 2:63-67.
36. Cartron P.F., Juin P., Oliver L., Martin S., Meflah K., Vallette F.M. Nonredundant role of Bax and Bak in Bid-mediated apoptosis. Mol. Cell. Biol. 2003, 23:4701-4712.
37. Scorrano L., Korsmeyer S.J. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem. Biophys. Res. Commun. 2003, 304:437-444.
38. Daugas E., Susin S.A., Zamzami N., Ferri K.F., Irinopoulou T., Larochette N., Prevost M.C., Leber B., Andrews D., Penninger J., Kroemer G. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 2000, 14:729-739.
39. Daugas E., Nochy D., Ravagnan L., Loeffler M., Susin S.A., Zamzami N., Kroemer G. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 2000, 476:118-123.
40. Lipton S.A., Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 2002, 111:147-150.