P 4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth

FEBS Letters

Volumn 586, Issue 13, 2012, Pages 1803-1812

  Xu, Qin ^a   Yang, Guo Ying ^b   Liu, Na ^a   Xu, Peng ^a   Chen, Yue Lei ^a   Zhou, Zheng ^b   Luo, Zhen Ge ^b   Ding, Xiaoyan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

CDC50 protein; Flippase; Neuronal differentiation; P 4 ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CDC50A; LIPID; LIPID FLIPPASE; MESSENGER RNA; P4 ATPASE ATP8A2; PHOSPHOLIPID; PROTEIN; UNCLASSIFIED DRUG; ATP8A2 PROTEIN, RAT; CDC50A PROTEIN, RAT; MEMBRANE PROTEIN; NERVE GROWTH FACTOR; PHOSPHOLIPID TRANSFER PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL FUNCTION; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CELL STRAIN; CONTROLLED STUDY; GENE; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; ANIMAL; CELL DIFFERENTIATION; CELL STRAIN HEK293; GENETICS; METABOLISM; MOUSE; NEURITE; RAT; RNA INTERFERENCE;

RATTUS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL DIFFERENTIATION; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MEMBRANE PROTEINS; MICE; NERVE GROWTH FACTOR; NEURITES; NEURONS; PC12 CELLS; PHOSPHOLIPID TRANSFER PROTEINS; RATS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84862504395     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.05.018     Document Type: Article

References (30)

1. van Meer, G., Voelker, D.R. and Feigenson, G.W. (2008) Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 9, 112-124. (Pubitemid 351158912)
2. Op den Kamp, J.A. (1979) Lipid asymmetry in membranes. Annu. Rev. Biochem. 48, 47-71.
3. Alder-Baerens, N., Lisman, Q., Luong, L., Pomorski, T. and Holthuis, J.C. (2006) Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol. Biol. Cell 17, 1632-1642. (Pubitemid 44011581)
4. Xu, P., Okkeri, J., Hanisch, S., Hu, R.Y., Xu, Q., Pomorski, T.G. and Ding, X.Y. (2009) Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis. J. Cell Sci. 122, 2866-2876.
5. Bull, L.N., van Eijk, M.J., Pawlikowska, L., DeYoung, J.A., Juijn, J.A., Liao, M., Klomp, L.W., Lomri, N., Berger, R., Scharschmidt, B.F., Knisely, A.S., Houwen, R.H. and Freimer, N.B. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat. Genet. 18, 219-224. (Pubitemid 28117258)
6. Zhou, X. and Graham, T.R. (2009) Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast. Proc. Natl. Acad. Sci. U S A 106, 16586-16591.
7. Cacciagli, P., Haddad, M.R., Mignon-Ravix, C., El-Waly, B., Moncla, A., Missirian, C., Chabrol, B. and Villard, L. (2010) Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype. Eur. J. Hum. Genet. 18, 1360-1363.
8. Coleman, J.A., Kwok, M.C. and Molday, R.S. (2009) Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes. J. Biol. Chem. 284, 32670-32679.
9. Halleck, M.S., Lawler, J.F.J.R., Blackshaw, S., Gao, L., Nagarajan, P., Hacker, C., Pyle, S., Newman, J.T., Nakanishi, Y., Ando, H., Weinstock, D., Williamson, P. and Schlegel, R.A. (1999) Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics. 1, 139-150. (Pubitemid 129622461)
10. Saito, K., Fujimura-Kamada, K., Furuta, N., Kato, U., Umeda, M. and Tanaka, K. (2004) Cdc50p, a protein required for polarized growth, associates with the Drs2p P-type ATPase implicated in phospholipid translocation in Saccharomyces cerevisiae. Mol. Biol. Cell 15, 3418-3432. (Pubitemid 38850134)
11. Lenoir, G., Williamson, P., Puts, C.F. and Holthuis, J.C. (2009) Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p. J. Biol. Chem. 284, 17956-17967.
12. Kato, U., Emoto, K., Fredriksson, C., Nakamura, H., Ohta, A., Kobayashi, T., Murakami-Murofushi, K., Kobayashi, T. and Umeda, M. (2002) A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. J. Biol. Chem. 277, 37855-37862.
13. Katoh, Y. and Katoh, M. (2004) Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Oncol. Rep. 12, 939-943.
14. van der Velden, L.M., Wichers, C.G., van Breevoort, A.E., Coleman, J.A., Molday, R.S., Berger, R., Klomp, L.W. and van de Graaf, S.F. (2010) Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J. Biol. Chem. 285, 40088-40096.
15. Coleman, J.A. and Molday, R.S. (2011) Critical role of the {beta}-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2. J. Biol. Chem. 286, 17205-17216.
16. Chen, Y.M., Wang, Q.J., Hu, H.S., Yu, P.C., Zhu, J., Drewes, G., Piwnica-Worms, H. and Luo, Z.G. (2006) Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc. Natl. Acad. Sci. U S A 103, 8534-8539. (Pubitemid 43838490)
17. Chen, Y.L., Liu, B., Zhou, Z.N., Hu, R.Y., Fei, C., Xie, Z.H. and Ding, X. (2009) Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation. J. Biol. Chem. 284, 23481-23490.
18. Chen, Y.L., Lv, J., Ye, X.L., Sun, M.Y., Xu, Q., Liu, C.H., Min, L.H., Li, H.P., Liu, P. and Ding, X. (2011) Sorafenib inhibits transforming growth factor b1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 53, 1708-1718.
19. Lou, X., Fang, P., Li, S., Hu, R.Y., Kuerner, K.M., Steinbeisser, H. and Ding, X. (2006) Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling. Cell Res. 16, 771-779. (Pubitemid 44395437)
20. Karamoysoyli, E., Burnand, R.C., Tomlinson, D.R. and Gardiner, N.J. (2008) Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. Diabetes 57, 181-189.
21. Zhang, X., Zhu, J., Yang, G.Y., Wang, Q.J., Qian, L., Chen, Y.M., Chen, F., Tao, Y., Hu, H.S., Wang, T. and Luo, Z.G. (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol. 9, 743-754. (Pubitemid 47019461)
22. Vaudry, D., Stork, P.J., Lazarovici, P. and Eiden, L.E. (2002) Signaling pathways for PC12 cell differentiation: making the right connections. Science 296, 1648-1649. (Pubitemid 34579153)
23. Greene, L.A. and Tischler, A.S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U S A 73, 2424-2428.
24. Xiao, J. and Liu, Y. (2003) Differential roles of ERK and JNK in early and late stages of neuritogenesis: a study in a novel PC12 model system. J. Neurochem. 86, 1516-1523. (Pubitemid 37174268)
25. Kühlbrandt, W. (2004) Biology, structure and mechanism of P-type ATPases. Nat. Rev. Mol. Cell Biol. 5, 282-295.
26. Dotti, C.G., Sullivan, C.A. and Banker, G.A. (1988) The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8, 1454-1468.
27. Sann, S., Wang, Z., Brown, H. and Jin, Y. (2009) Roles of endosomal trafficking in neurite outgrowth and guidance. Trends. Cell Biol. 19, 317-324.
28. Matteoli, M., Coco, S., Schenk, U. and Verderio, C. (2004) Vesicle turnover in developing neurons: how to build a presynaptic terminal. Trends Cell Biol. 14, 133-140. (Pubitemid 38293456)
29. Martinez-Arca, S., Coco, S., Mainguy, G., Schenk, U., Alberts, P., Bouillé, P., Mezzina, M., Prochiantz, A., Matteoli, M., Louvard, D. and Galli, T. (2001) A common exocytotic mechanism mediates axonal and dendritic outgrowth. J. Neurosci. 21, 3830-3838. (Pubitemid 32466475)
30. Li, M.O., Sarkisian, M.R., Mehal, W.Z., Rakic, P. and Flavell, R.A. (2003) Phosphatidylserine receptor is required for clearance of apoptotic cells. Science 302, 1560-1563. (Pubitemid 37475698)