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A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)
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Targeted PARACEST nanoparticle contrast agent for the detection of fibrin
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An example of fibrin-targeting with a paraCEST contrast agent with possible transfer to the clinic
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Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization. Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging
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Description of the T1 contrast properties of iron oxide-based nanoparticles, which have less toxicity issues when compared to gadolinium-based nanoparticles. Positive contrast caused by shortened T1 is not masked by susceptibility artifacts and area of contrast uptake will not be overestimated as is the case with T2* contrast
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• Taboada E, Rodriguez E, Roig A, et al. Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization. Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging. Langmuir. 2007; 23: 4583-8. Description of the T1 contrast properties of iron oxide-based nanoparticles, which have less toxicity issues when compared to gadolinium-based nanoparticles. Positive contrast caused by shortened T1 is not masked by susceptibility artifacts and area of contrast uptake will not be overestimated as is the case with T2* contrast.
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