Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis

Journal of Lipid Research

Volumn 50, Issue 11, 2009, Pages 2157-2163

  Maiseyeu, Andrei ^a   Mihai, Georgeta ^a   Kampfrath, Thomas ^a   Simonetti, Orlando P ^a   Sen, Chandan K ^b   Roy, Sashwati ^a   Rajagopalan, Sanjay ^a   Parthasarathy, Sampath ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

ApoE mouse model; Apoptosis mimicking; Cellular uptake; Colocalization with macrophages; Macrophages

Indexed keywords

GADOLINIUM; PHOSPHATIDYLSERINE; RHODAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG UPTAKE; IMAGE ENHANCEMENT; MACROPHAGE; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ANIMALS; AORTA, ABDOMINAL; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL LINE; CONTRAST MEDIA; GADOLINIUM; LIPOSOMES; MACROPHAGES; MAGNETIC RESONANCE IMAGING; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MOLECULAR IMAGING; PHOSPHATIDYLSERINES; SENSITIVITY AND SPECIFICITY;

EID: 70350379588     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800405-JLR200     Document Type: Article

References (22)

1. Wickline, S. A., A. M. Neubauer, P. M. Winter, S. D. Caruthers, and G. M. Lanza. 2007. Molecular imaging and therapy of atherosclerosis with targeted nanoparticles. J. Magn. Reson. Imaging. 25: 667-680.
2. Jaffer, F. A., P. Libby, and R. Weissleder. 2007. Molecular imaging of cardiovascular disease. Circulation. 116: 1052-1061.
3. Jaffer, F. A., and R. Weissleder. 2005. Molecular imaging in the clinical arena. JAMA. 293: 855-862.
4. Frias, J. C., K. J. Williams, E. A. Fisher, and Z. A. Fayad. 2004. Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. J. Am. Chem. Soc. 126: 16316-16317.
5. Corbin, I. R., H. Li, J. Chen, S. Lund-Katz, R. Zhou, J. D. Glickson, and G. Zheng. 2006. Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents. Neoplasia. 8: 488-498.
6. Amirbekian, V., M. J. Lipinski, K. C. Briley-Saebo, S. Amirbekian, J. G. S. Aguinaldo, D. B. Weinreb, E. Vucic, J. C. Frias, F. Hyafil, V. Mani, et al. 2007. Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc. Natl. Acad. Sci. USA. 104: 961-966.
7. Mulder, W. J. M., G. J. Strijkers, K. C. Briley-Saboe, J. C. Frias, J. G. S. Aguinaldo, E. Vucic, V. Amirbekian, C. Tang, P. T. K. Chin, K. Nicolay, et al. 2007. Molecular imaging of macrophages in atherosclerotic plaques using bimodal PEG-micelles. Magn. Reson. Med. 58: 1164-1170.
8. Mulder, W. J., K. Douma, G. A. Koning, M. A. van Zandvoort, E. Lutgens, M. J. Daemen, K. Nicolay, and G. J. Strijkers. 2006. Liposome-enhanced MRI of neointimal lesions in the ApoE-KO mouse. Magn. Reson. Med. 55: 1170-1174.
9. Sofou, S. 2007. Surface-active liposomes for targeted cancer therapy. Nanomedicine. 2: 711-724.
10. Klibanov, A. L., K. Maruyama, A. M. Beckerleg, V. P. Torchilin, and L. Huang. 1991. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062: 142-148.
11. Henson, P. M., D. L. Bratton, and V. A. Fadok. 2001. Apoptotic cell removal. Curr. Biol. 11: R795-R805.
12. Tait, J. F., and C. Smith. 1999. Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells. J. Biol. Chem. 274: 3048-3054.
13. Prosser, R. S., H. Bryant, R. G. Bryant, and R. R. Vold. 1999. Lanthanide chelates as bilayer alignment tools in NMR studies of membrane-associated peptides. J. Magn. Reson. 141: 256-260.
14. Kabalka, G. W., M. A. Davis, T. H. Moss, E. Buonocore, K. Hubner, E. Holmberg, K. Maruyama, and L. Huang. 1991. Gadolinium-labeled liposomes containing various amphiphilic Gd-DTPA derivatives: targeted MRI contrast enhancement agents for the liver. Magn. Reson. Med. 19: 406-415.
15. Stewart, J. C. 1980. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal. Biochem. 104: 10-14.
16. National Institutes of Health. 1985. Guide for the Care and Use of Laboratory Animals. NIH Publication No. 86-23, revised 1985. NIH, Washington, DC.
17. Bogaert, J. S. D., and A. M. Taylor. 2005. Clinical Cardiac MRI. Springer, New York.
18. Ravichandran, K. S., and U. Lorenz. 2007. Engulfment of apoptotic cells: signals for a good meal. Nat. Rev. Immunol. 7: 964-974.
19. Huynh, M. L. N., V. A. Fadok, and P. M. Henson. 2002. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta 1 secretion and the resolution of inflammation. J. Clin. Invest. 109: 41-50.
20. Briley-Saebo, K. C., P. X. Shaw, W. J. Mulder, S. H. Choi, E. Vucic, J. G. Aguinaldo, J. L. Witztum, V. Fuster, S. Tsimikas, and Z. A. Fayad. 2008. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation 117: 3206-3215.
21. Photos, P. J., L. Bacakova, B. Discher, F. S. Bates, and D. E. Discher. 2003. Polymer vesicles in vivo: correlations with PEG molecular weight. J. Control. Release. 90: 323-334.
22. Maruyama, K., T. Yuda, A. Okamoto, S. Kojima, A. Suginaka, and M. Iwatsuru. 1992. Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoyl phosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol). Biochim. Biophys. Acta. 1128: 44-49.