Mouse dendritic cells pulsed with capsular polysaccharide induce resistance to lethal pneumococcal challenge: Roles of t cells and b cells

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Cohen, Noam ^a   Margalit, Raanan ^a   Pevsner Fischer, Meirav ^a   Yona, Simon ^a   Jung, Steffen ^a   Eisenbach, Lea ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL CAPSULAR POLYSACCHARIDE; BACTERIAL POLYSACCHARIDE; DENDRITIC CELL VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; PNEUMOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; BACTERIAL GROWTH; BONE MARROW DENDRITIC CELL; CELL SURFACE; CELLULAR DISTRIBUTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENTIATION; DRUG PULSE THERAPY; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; INFECTION PREVENTION; LETHAL DOSE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MONOTHERAPY; MOUSE; NONHUMAN; PERITONEUM; PNEUMOCOCCAL INFECTION; SINGLE DRUG DOSE; STREPTOCOCCUS PNEUMONIAE; T LYMPHOCYTE;

ANIMALS; ANTIBODY SPECIFICITY; ANTIGEN PRESENTATION; ANTIGENS, CD1D; B-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERFERON-GAMMA; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; PERITONEUM; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; POLYSACCHARIDES, BACTERIAL; RECEPTORS, ANTIGEN, T-CELL; STREPTOCOCCUS PNEUMONIAE; T-LYMPHOCYTES; TIME FACTORS;

EID: 84862489716     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039193     Document Type: Article

References (35)

1. AlonsoDeVelasco E, Verheul AF, Verhoef J, Snippe H, (1995) Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol Rev 59: 591-603.
2. Calbo E, Garau J, (2011) Factors affecting the development of systemic inflammatory response syndrome in pneumococcal infections. Curr Opin Infect Dis 24: 241-247.
3. Hilleman MR, McLean AA, Vella PP, Weibel RE, Woodhour AF, (1978) Polyvalent pneumococcal polysaccharide vaccines. Bull World Health Organ 56: 371-375.
4. Smit P, Oberholzer D, Hayden-Smith S, Koornhof HJ, Hilleman MR, (1977) Protective efficacy of pneumococcal polysaccharide vaccines. JAMA 238: 2613-2616.
5. French N, Nakiyingi J, Carpenter LM, Lugada E, Watera C, et al. (2000) 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial. Lancet 355: 2106-2111.
6. Douglas RM, Paton JC, Duncan SJ, Hansman DJ, (1983) Antibody response to pneumococcal vaccination in children younger than five years of age. J Infect Dis 148: 131-137.
7. Selman S, Hayes D, Perin LA, Hayes WS, (2000) Pneumococcal conjugate vaccine for young children. Manag Care 9: 49-52, 54, 56-47 passim.
8. Nuorti JP, Whitney CG, (2010) Prevention of pneumococcal disease among infants and children - use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine - recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59: 1-18.
9. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
10. Steinman RM, (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9: 271-296.
11. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, et al. (2010) Development of monocytes, macrophages, and dendritic cells. Science 327: 656-661.
12. Cohen N, Stolarsky-Bennun M, Amir-Kroll H, Margalit R, Nussbaum G, et al. (2008) Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive. J Immunol 180: 2409-2418.
13. Jiang SM, Wang L, Reeves PR, (2001) Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters. Infect Immun 69: 1244-1255.
14. Garcia E, Lopez R, (1997) Molecular biology of the capsular genes of Streptococcus pneumoniae. FEMS Microbiol Lett 149: 1-10.
15. Saeki H, Moore AM, Brown MJ, Hwang ST, (1999) Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol 162: 2472-2475.
16. Jensen KD, Su X, Shin S, Li L, Youssef S, et al. (2008) Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity 29: 90-100.
17. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, et al. (2001) Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 276: 31332-31339.
18. Cobb BA, Wang Q, Tzianabos AO, Kasper DL, (2004) Polysaccharide processing and presentation by the MHCII pathway. Cell 117: 677-687.
19. Meltzer U, Goldblatt D, (2006) Pneumococcal polysaccharides interact with human dendritic cells. Infect Immun 74: 1890-1895.
20. Stephen TL, Fabri M, Groneck L, Rohn TA, Hafke H, et al. (2007) Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules. PLoS Pathog 3: e32.
21. Lai Z, Schreiber JR, (2009) Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface. Vaccine 27: 3137-3144.
22. Brown EJ, Hosea SW, Frank MM, (1983) The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream. Rev Infect Dis 5: S797-805.
23. Schiffman G, (1983) Pneumococcal vaccine: a tool for the evaluation of the B-cell function of the immune system. Proc Soc Exp Biol Med 174: 309-315.
24. Watson DA, Musher DM, Verhoef J, (1995) Pneumococcal virulence factors and host immune responses to them. Eur J Clin Microbiol Infect Dis 14: 479-490.
25. Amir-Kroll H, Nussbaum G, Cohen IR, (2003) Proteins and their derived peptides as carriers in a conjugate vaccine for Streptococcus pneumoniae: self-heat shock protein 60 and tetanus toxoid. J Immunol 170: 6165-6171.
26. Muthukkumar S, Stein KE, (2004) Immunization with meningococcal polysaccharide-tetanus toxoid conjugate induces polysaccharide-reactive T cells in mice. Vaccine 22: 1290-1299.
27. Yanez DM, Batchelder J, van der Heyde HC, Manning DD, Weidanz WP, (1999) Gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA. Infect Immun 67: 446-448.
28. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295: 338-342.
29. Dallaire F, Ouellet N, Bergeron Y, Turmel V, Gauthier MC, et al. (2001) Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia. J Infect Dis 184: 292-300.
30. Tuomanen EI, (1997) The biology of pneumococcal infection. Pediatr Res 42: 253-258.
31. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, et al. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99: 23-33.
32. Schweitzer AN, Borriello F, Wong RC, Abbas AK, Sharpe AH, (1997) Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J Immunol 158: 2713-2722.
33. Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH, (1991) Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253: 1417-1420.
34. Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, et al. (1994) The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1: 167-178.
35. Koller BH, Marrack P, Kappler JW, Smithies O, (1990) Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248: 1227-1230.