Opposite effects of polyols on antibody aggregation: Thermal versus mechanical stresses

Pharmaceutical Research

Volumn 29, Issue 3, 2012, Pages 683-694

  Abbas, Shermeen A ^a   Sharma, Vikas K ^b   Patapoff, Thomas W ^b   Kalonia, Devendra S ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b GENENTECH INC   (United States)

Author keywords

Antibody aggregation; Preferential exclusion; Protein adsorption; Protein conformational stability; Protein solubility

Indexed keywords

ETHYLENE GLYCOL; GLYCEROL; MONOCLONAL ANTIBODY; POLYOL; SUCROSE; TREHALOSE;

ADSORPTION KINETICS; ANTIGEN STRUCTURE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; MECHANICAL STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; PROTEIN UNFOLDING; REACTION TIME; TEMPERATURE SENSITIVITY; TEMPERATURE STRESS; TRANSITION TEMPERATURE; ADSORPTION; CHEMISTRY; SOLUBILITY; TEMPERATURE;

ADSORPTION; ANTIBODIES, MONOCLONAL; ETHYLENE GLYCOL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; SOLUBILITY; STRESS, MECHANICAL; SUCROSE; TEMPERATURE; TREHALOSE;

EID: 84862315901     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0593-4     Document Type: Article

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