Plasmodium falciparum possesses a unique dual-specificity serine/threonine and tyrosine kinase, Pfnek3

Cellular and Molecular Life Sciences

Volumn 69, Issue 9, 2012, Pages 1523-1535

  Low, Huiyu ^a   Chua, Chun Song ^a   Sim, Tiow Suan ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Dual specificity kinase; Malaria; MAPKK; Phosphorylation; Plasmodium falciparum

Indexed keywords

MAGNESIUM; MANGANESE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYELIN BASIC PROTEIN; PFNEK3 PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RECOMBINANT ENZYME; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG; PRIMER DNA; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; METAL BINDING; NONHUMAN; PLASMODIUM FALCIPARUM; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; WESTERN BLOTTING; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

PLASMODIUM FALCIPARUM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; DNA PRIMERS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84862311160     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0888-y     Document Type: Article

References (38)

1. Hanks SK, Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9(8):576-596
2. Manning G, Plowman GD, Hunter T, Sudarsanam S (2002) Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci 27(10):514-520 (Pubitemid 35279596)
3. Hanks SK, Quinn AM, Hunter T (1988) The protein kinase family: conserved features and deduced phylogeny of the cata-lytic domains. Science 241(4861):42-52
4. Lindberg RA, Quinn AM, Hunter T (1992) Dual-specificity protein kinases: will any hydroxyl do? Trends Biochem Sci 17(3):114-119
5. Thalhamer T, Mc Grath MA, Harnett MM (2008) MAPKs and their relevance to arthritis and inflammation. Rheumatology (Oxford) 47(4):409-414
6. Schramek H (2002) MAP kinases: from intracellular signals to physiology and disease. News Physiol Sci 17:62-67
7. Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802(4): 396-405
8. Capdeville R, Buchdunger E, Zimmermann J, Matter A (2002) Glivec (STI571, imatinib), a rationally developed, targeted anti-cancer drug. Nat Rev Drug Discov 1(7):493-502
9. World-Health-Organization (2010) World malaria Report 2010
10. Doerig C (2004) Protein kinases as targets for anti-parasitic chemotherapy. Biochim Biophys Acta 1697(1-2):155-168 (Pubitemid 38326769)
11. Dondorp AM, Yeung S, White L, Nguon C, Day NP, Socheat D, von Seidlein L (2010) Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol 8(4):272-280
12. Rosenthal PJ (2003) Antimalarial drug discovery: old and new approaches. J Exp Biol 206(Pt21):3735-3744 (Pubitemid 37365455)
13. Ward P, Equinet L, Packer J, Doerig C (2004) Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics 5(1):79
14. Anamika K, Srinivasan N, Krupa A (2005) A genomic perspec-tive of protein kinases in Plasmodium falciparum. Proteins 58(1):180-189 (Pubitemid 39665629)
15. Doerig C, Meijer L (2007) Antimalarial drug discovery: targeting protein kinases. Expert Opin Ther Targets 11(3):279-290 (Pubitemid 46290953)
16. Jirage D, Keenan SM, Waters NC (2010) Exploring novel targets for antimalarial drug discovery: plasmodial protein kinases. Infect Disord Drug Targets 10(3):134-146
17. Dorin D, Alano P, Boccaccio I, Ciceron L, Doerig C, Sulpice R, Parzy D (1999) An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Identification of a MAPK signature. J Biol Chem 274(42):29912-29920
18. Dorin-Semblat D, Quashie N, Halbert J, Sicard A, Doerig C, Peat E, Ranford-Cartwright L (2007) Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics. Mol Microbiol 65(5):1170-1180 (Pubitemid 47262821)
19. Dorin D, Le Roch K, Sallicandro P, Alano P, Parzy D, Poullet P, Meijer L, Doerig C (2001) Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodiumfalciparum Biochemical properties and possible involvement in MAPK regulation. Eur J Biochem 268(9):2600-2608 (Pubitemid 32852997)
20. Lye YM, Chan M, Sim TS (2006) Pfnek3: an atypical activator of a MAP kinase in Plasmodium falciparum. FEBS Lett 580(26): 6083-6092 (Pubitemid 44666788)
21. Low H, Lye YM, Sim TS (2007) Pfnek3 functions as an atypical MAPKK in Plasmodium falciparum. Biochem Biophys Res Commun 361(2):439-444 (Pubitemid 47187277)
22. Zhang Y, Dong C (2007) Regulatory mechanisms of mitogen-activated kinase signaling. Cell Mol Life Sci 64(21):2771-2789 (Pubitemid 351152255)
23. Low H, Chua CS, Sim TS (2009) Regulation of Plasmodium falciparum Pfnek3 relies on phosphorylation at its activation loop and at threonine 82. Cell Mol Life Sci 66(18):3081-3090
24. Abramoff MD, Magalhaes PJ, Ram SJ (2004) Image processing with Image J. Biophotonics Int 11(7):36-42
25. Blom N, Gammeltoft S, Brunak S (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 294(5):1351-1362 (Pubitemid 30008805)
26. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-Pdb Viewer: an environment for comparative protein modeling. Electrophoresis 18(15):2714-2723 (Pubitemid 28059943)
27. Nolen B, Taylor S, Ghosh G (2004) Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell 15(5):661-675 (Pubitemid 39194898)
28. Johnson LN, Noble ME, Owen DJ (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85(2): 149-158 (Pubitemid 26118158)
29. Adams JA (2003) Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoin-hibitor model? Biochemistry 42(3):601-607 (Pubitemid 36133283)
30. Swarup G, Dasgupta JD, Garbers DL (1984) Tyrosine-specific protein kinases of normal tissues. Adv Enzym Regul 22:267-288
31. Yuan CJ, Huang CY, Graves DJ (1993) Phosphorylase kinase, a metal ion-dependent dual specificity kinase. J Biol Chem 268(24):17683-17686 (Pubitemid 23260272)
32. Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG (1991) Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and thre-onine residues: implications for their mechanism of activation. Proc Natl Acad Sci USA 88(14):6142-6146 (Pubitemid 21914902)
33. Rossomando AJ, Wu J, Michel H, Shabanowitz J, Hunt DF, Weber MJ, Sturgill TW (1992) Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk. Proc Natl Acad Sci USA 89(13):5779-5783
34. Graeser R, Kury P, Franklin RM, Kappes B (1997) Characteri-zation of a mitogen-activated protein (MAP) kinase from Plasmodiumfalciparum. Mol Microbiol 23(1):151-159 (Pubitemid 26423561)
35. Sharma A (2000) Protein tyrosine kinase activity in human malaria parasite Plasmodium falciparum. Indian J Exp Biol 38(12):1222-1226 (Pubitemid 32122434)
36. Sharma A, Mishra NC (1999) Inhibition of a protein tyrosine kinase activity in Plasmodium falciparum by chloroquine. Indian J Biochem Biophys 36(5):299-304 (Pubitemid 129483032)
37. Kumar R, Musiyenko A, Cioffi E, Oldenburg A, Adams B, Bitko V, Krishna SS, Barik S (2004) A zinc-binding dual-specificity YVH1 phosphatase in the malaria parasite, Plasmodium falci-parum, and its interaction with the nuclear protein, pescadillo. Mol Biochem Parasitol 133(2):297-310 (Pubitemid 38032877)
38. Pendyala PR, Ayong L, Eatrides J, Schreiber M, Pham C, Chakrabarti R, Fidock DA, Allen CM, Chakrabarti D (2008) Characterization of a PRL protein tyrosine phosphatase from Plasmodiumfalciparum. Mol Biochem Parasitol 158(1):1-10 (Pubitemid 351172458)