Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5337-5349

  Hong, Seunghee ^a   Kim, Jinhee ^a   Seo, Ju Hyeon ^b   Jung, Kyung Hee ^b   Hong, Soon Sun ^b   Hong, Sungwoo ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE INHIBITOR;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZA COMPOUNDS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDOLES; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84862280700     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3002982     Document Type: Article

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