Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

ACS Medicinal Chemistry Letters

Volumn 3, Issue 6, 2012, Pages 509-514

  Soares Da Costa, Tatiana P ^a   Tieu, William ^a   Yap, Min Y ^b   Zvarec, Ondrej ^a,d   Bell, Jan M ^c   Turnidge, John D ^a,c   Wallace, John C ^a   Booker, Grant W ^a   Wilce, Matthew C J ^b   Abell, Andrew D ^a   Polyak, Steven W ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

antibiotic; biotin protein ligase; enzyme; enzyme inhibitor; medicinal chemistry

Indexed keywords

BIOTIN DERIVATIVE; BIOTIN PROTEIN LIGASE; LIGASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

EID: 84862275230     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300106p     Document Type: Article

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