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Volumn 151, Issue 6, 2012, Pages 563-571

Transcriptional and Post-transcriptional Regulation in TGF-β-mediated epithelial-mesenchymal transition

Author keywords

EMT; ESRP alternative splicing; TGF

Indexed keywords

CATENIN; FIBROBLAST GROWTH FACTOR 2; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 1; HOMEODOMAIN PROTEIN; RAS PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UVOMORULIN;

EID: 84862274773     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs040     Document Type: Review
Times cited : (47)

References (64)
  • 2
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGF-b signaling through Smads
    • Feng, X.H. and Derynck, R. (2005) Specificity and versatility in TGF-b signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 3
    • 0034785348 scopus 로고    scopus 로고
    • TGF-B signaling in tumor suppression and cancer progression
    • Derynck, R., Akhurst, R.J., and Balmain, A. (2001) TGF-b signaling in tumor suppression and cancer progression. Nat. Genet. 29, 117-129
    • (2001) Nat. Genet. , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 4
    • 79251556820 scopus 로고    scopus 로고
    • Smad7: Not only a regulator, but also a cross-Talk mediator of TGF-B signalling
    • Yan, X. and Chen, Y.G. (2011) Smad7: not only a regulator, but also a cross-talk mediator of TGF-b signalling. Biochem. J. 434, 1-10
    • (2011) Biochem. J. , vol.434 , pp. 1-10
    • Yan, X.1    Chen, Y.G.2
  • 5
    • 55449107515 scopus 로고    scopus 로고
    • Regulation of TGF-B family signaling by E3 ubiquitin ligases
    • Inoue, Y. and Imamura, T. (2008) Regulation of TGF-b family signaling by E3 ubiquitin ligases. Cancer Sci. 99, 2107-2112
    • (2008) Cancer Sci. , vol.99 , pp. 2107-2112
    • Inoue, Y.1    Imamura, T.2
  • 6
    • 0141537150 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-b receptor exhibit impaired mammary development and enhanced mammary tumor formation
    • Gorska, A.E., Jensen, R.A., Shyr, Y., Aakre, M.E., Bhowmick, N.A., and Moses, H.L. (2003) Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-b receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am. J. Pathol. 163, 1539-1549
    • (2003) Am. J. Pathol. , vol.163 , pp. 1539-1549
    • Gorska, A.E.1    Jensen, R.A.2    Shyr, Y.3    Aakre, M.E.4    Bhowmick, N.A.5    Moses, H.L.6
  • 8
    • 80054044729 scopus 로고    scopus 로고
    • Enhancement of TGF-b signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer
    • Sharma, v., Antonacopoulou, A.G., Tanaka, S., Panoutsopoulos, A.A., Bravou, v., Kalofonos, H.P., and Episkopou, v. (2011) Enhancement of TGF-b signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer. Cancer Res. 71, 6438-6449
    • (2011) Cancer Res. , vol.71 , pp. 6438-6449
    • Sharma, V.1    Antonacopoulou, A.G.2    Tanaka, S.3    Panoutsopoulos, A.A.4    Bravou, V.5    Kalofonos, H.P.6    Episkopou, V.7
  • 9
    • 77953695161 scopus 로고    scopus 로고
    • Cellular and molecular basis for the regulation of inflammation by TGF-b
    • Yoshimura, A., Wakabayashi, Y., and Mori, T. (2010) Cellular and molecular basis for the regulation of inflammation by TGF-b. J. Biochem. 147, 781-792
    • (2010) J. Biochem. , vol.147 , pp. 781-792
    • Yoshimura, A.1    Wakabayashi, Y.2    Mori, T.3
  • 10
    • 47549090432 scopus 로고    scopus 로고
    • TGFb in cancer
    • Massague, J. (2008) TGFb in cancer. Cell 134, 215-230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 12
    • 78650655487 scopus 로고    scopus 로고
    • Autocrine TGF-b protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim
    • Hoshino, Y., Katsuno, Y., Ehata, S., and Miyazono, K. (2011) Autocrine TGF-b protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. J. Biochem. 149, 55-65
    • (2011) J. Biochem. , vol.149 , pp. 55-65
    • Hoshino, Y.1    Katsuno, Y.2    Ehata, S.3    Miyazono, K.4
  • 13
    • 0029101527 scopus 로고
    • Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-b 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype
    • Caulin, C., Scholl, F.G., Frontelo, P., Gamallo, C., and Quintanilla, M. (1995) Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-b 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ. 6, 1027-1035
    • (1995) Cell Growth Differ. , vol.6 , pp. 1027-1035
    • Caulin, C.1    Scholl, F.G.2    Frontelo, P.3    Gamallo, C.4    Quintanilla, M.5
  • 14
    • 74949093198 scopus 로고    scopus 로고
    • Transforming growth factor-B signaling in epithelial-Mesenchymal transition and progression of cancer
    • Miyazono, K. (2009) Transforming growth factor-b signaling in epithelial-mesenchymal transition and progression of cancer. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 85, 314-323
    • (2009) Proc. Jpn Acad. Ser. B Phys. Biol. Sci. , vol.85 , pp. 314-323
    • Miyazono, K.1
  • 15
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-Mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas, A. and Heldin, C.H. (2007) Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 98, 1512-1520
    • (2007) Cancer Sci. , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 16
    • 79957809539 scopus 로고    scopus 로고
    • Cancer early dissemination: Cancerous epithelial-Mesenchymal transdifferentiation and transforming growth factor b signalling
    • Sabe, H. (2011) Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor b signalling. J. Biochem. 149, 633-639
    • (2011) J. Biochem. , vol.149 , pp. 633-639
    • Sabe, H.1
  • 17
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J.P., Acloque, H., Huang, R.Y., and Nieto, M.A. (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139, 871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 18
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-Mesenchymal transition
    • Kalluri, R. and Weinberg, R.A. (2009) The basics of epithelial- mesenchymal transition. J. Clin. Invest. 119, 1420-1428
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 19
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-Induced EMT of cancer cells
    • Kudo-Saito, C., Shirako, H., Takeuchi, T., and Kawakami, Y. (2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15, 195-206
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 20
    • 0036513626 scopus 로고    scopus 로고
    • The Snail superfamily of zinc-Finger transcription factors
    • Nieto, M.A. (2002) The Snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol. 3, 155-166
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 21
    • 0028603343 scopus 로고
    • TGF-B induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen, P.J., Ebner, R., Lopez, A.R., and Derynck, R. (1994) TGF-b induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 127, 2021-2036
    • (1994) J. Cell Biol. , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 22
    • 2942536704 scopus 로고    scopus 로고
    • Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor b and bone morphogenetic protein
    • Kowanetz, M., valcourt, U., Bergstrom, R., Heldin, C.H., and Moustakas, A. (2004) Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor b and bone morphogenetic protein. Mol. Cell. Biol. 24, 4241-4254
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4241-4254
    • Kowanetz, M.1    Valcourt, U.2    Bergstrom, R.3    Heldin, C.H.4    Moustakas, A.5
  • 25
    • 84859986242 scopus 로고    scopus 로고
    • JunB contributes to Id2 repression and the epithelial-Mesenchymal transition in response to transforming growth factor-b
    • Gervasi, M., Bianchi-Smiraglia, A., Cummings, M., Zheng, Q., Wang, D., Liu, S., and Bakin, A.v. (2012) JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-b. J. Cell Biol. 196, 589-603
    • (2012) J. Cell Biol. , Issue.196 , pp. 589-603
    • Gervasi, M.1    Bianchi-Smiraglia, A.2    Cummings, M.3    Zheng, Q.4    Wang, D.5    Liu, S.6    Bakin, A.V.7
  • 27
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by dEF1 proteins in epithelial mesenchymal transition induced by TGF-b
    • Shirakihara, T., Saitoh, M., and Miyazono, K. (2007) Differential regulation of epithelial and mesenchymal markers by dEF1 proteins in epithelial mesenchymal transition induced by TGF-b. Mol. Biol. Cell 18, 3533-3544
    • (2007) Mol. Biol. Cell , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 30
    • 0038324071 scopus 로고    scopus 로고
    • Opposing functions of ZEB proteins in the regulation of the TGF-b/BMP signaling pathway
    • Postigo, A.A. (2003) Opposing functions of ZEB proteins in the regulation of the TGF-b/BMP signaling pathway. EMBO J. 22, 2443-2452
    • (2003) EMBO J. , vol.22 , pp. 2443-2452
    • Postigo, A.A.1
  • 31
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-Mesenchymal transition
    • Bracken, C.P., Gregory, P.A., Kolesnikoff, N., Bert, A.G., Wang, J., Shannon, M.F., and Goodall, G.J. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68, 7846-7854
    • (2008) Cancer Res. , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 32
  • 36
    • 2442674220 scopus 로고    scopus 로고
    • Zinc transporter LIvI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
    • Yamashita, S., Miyagi, C., Fukada, T., Kagara, N., Che, Y.S., and Hirano, T. (2004) Zinc transporter LIvI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 429, 298-302
    • (2004) Nature , vol.429 , pp. 298-302
    • Yamashita, S.1    Miyagi, C.2    Fukada, T.3    Kagara, N.4    Che, Y.S.5    Hirano, T.6
  • 37
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3b-Mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B.P., Deng, J., Xia, W., Xu, J., Li, Y.M., Gunduz, M., and Hung, M.C. (2004) Dual regulation of Snail by GSK-3b-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6, 931-940
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7
  • 38
    • 58649104000 scopus 로고    scopus 로고
    • Small C-Terminal domain phosphatase enhances snail activity through dephosphorylation
    • Wu, Y., Evers, B.M., and Zhou, B.P. (2009) Small C-terminal domain phosphatase enhances Snail activity through dephosphorylation. J. Biol. Chem. 284, 640-648
    • (2009) J. Biol. Chem. , vol.284 , pp. 640-648
    • Wu, Y.1    Evers, B.M.2    Zhou, B.P.3
  • 40
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of Snail by NF-kb is required for inflammation-induced cell migration and invasion
    • Wu, Y., Deng, J., Rychahou, P.G., Qiu, S., Evers, B.M., and Zhou, B.P. (2009) Stabilization of Snail by NF-kB is required for inflammation-induced cell migration and invasion. Cancer Cell 15, 416-428
    • (2009) Cancer Cell , vol.15 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5    Zhou, B.P.6
  • 45
    • 77956988604 scopus 로고    scopus 로고
    • Pivotal role of Twist in skeletal biology and pathology
    • Miraoui, H. and Marie, P.J. (2010) Pivotal role of Twist in skeletal biology and pathology. Gene 468, 1 7
    • (2010) Gene , vol.468 , pp. 1-7
    • Miraoui, H.1    Marie, P.J.2
  • 47
    • 58149237893 scopus 로고    scopus 로고
    • Phosphoregulation of Twist1 provides a mechanism of cell fate control
    • Firulli, A.B. and Conway, S.J. (2008) Phosphoregulation of Twist1 provides a mechanism of cell fate control. Curr. Med. Chem. 15, 2641 2647
    • (2008) Curr. Med. Chem. , vol.15 , pp. 2641-2647
    • Firulli, A.B.1    Conway, S.J.2
  • 48
    • 84863229401 scopus 로고    scopus 로고
    • Interactions between beta-catenin and transforming growth factor-b signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding Protein (CBP)
    • Zhou, B., Liu, Y., Kahn, M., Ann, D.K., Han, A., Wang, H., Nguyen, C., Flodby, P., Zhong, Q., Krishnaveni, M.S., Liebler, J.M., Minoo, P., Crandall, E.D., and Borok, Z. (2012) Interactions between beta-catenin and transforming growth factor-b signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding Protein (CBP). J. Biol. Chem. 287, 7026 7038
    • (2012) J. Biol. Chem. , vol.287 , pp. 7026-7038
    • Zhou, B.1    Liu, Y.2    Kahn, M.3    Ann, D.K.4    Han, A.5    Wang, H.6    Nguyen, C.7    Flodby, P.8    Zhong, Q.9    Krishnaveni, M.S.10    Liebler, J.M.11    Minoo, P.12    Crandall, E.D.13    Borok, Z.14
  • 49
    • 84856463822 scopus 로고    scopus 로고
    • TGF-b-Induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells
    • Kawata, M., Koinuma, D., Ogami, T., Umezawa, K., Iwata, C., Watabe, T., and Miyazono, K. (2011) TGF-b-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J. Biochem. 151, 205 216
    • (2011) J. Biochem. , vol.151 , pp. 205-216
    • Kawata, M.1    Koinuma, D.2    Ogami, T.3    Umezawa, K.4    Iwata, C.5    Watabe, T.6    Miyazono, K.7
  • 50
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft, M., Akhurst, R.J., and Balmain, A. (2002) Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat. Cell Biol. 4, 487 494
    • (2002) Nat. Cell Biol. , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 52
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor-b 1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado, H., Quintanilla, M., and Cano, A. (2003) Transforming growth factor-b 1 induces Snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J. Biol. Chem. 278, 21113 21123
    • (2003) J. Biol. Chem. , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 53
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGFb signaling
    • Mulder, K.M. (2000) Role of Ras and Mapks in TGFb signaling. Cytokine Growth Factor Rev. 11, 23 35
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 54
    • 79551647444 scopus 로고    scopus 로고
    • Switching TGFb from a tumor suppressor to a tumor promoter
    • Inman, G.J. (2011) Switching TGFb from a tumor suppressor to a tumor promoter. Curr. Opin. Genet. Dev. 21, 93 99
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 93-99
    • Inman, G.J.1
  • 55
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan, Q., Shai, O., Lee, L.J., Frey, B.J., and Blencowe, B.J. (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet. 40, 1413 1415
    • (2008) Nat. Genet. , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 59
    • 61649087689 scopus 로고    scopus 로고
    • ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
    • Warzecha, C.C., Sato, T.K., Nabet, B., Hogenesch, J.B., and Carstens, R.P. (2009) ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol. Cell 33, 591 601
    • (2009) Mol. Cell , vol.33 , pp. 591-601
    • Warzecha, C.C.1    Sato, T.K.2    Nabet, B.3    Hogenesch, J.B.4    Carstens, R.P.5
  • 61
    • 77950552549 scopus 로고    scopus 로고
    • The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events
    • Warzecha, C.C., Shen, S., Xing, Y., and Carstens, R.P. (2009) The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biol. 6, 546 562
    • (2009) RNA Biol. , vol.6 , pp. 546-562
    • Warzecha, C.C.1    Shen, S.2    Xing, Y.3    Carstens, R.P.4
  • 62
    • 84861448736 scopus 로고    scopus 로고
    • TGF-B-Induced activation of mTOR complex 2 drives epithelial-Mesenchymal transition and cell invasion
    • Lamouille, S., Connolly, E., Smyth, J.W., Akhurst, R.J., and Derynck, R. (2012) TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J. Cell Sci. 125, 1 15
    • (2012) J. Cell Sci. , vol.125 , Issue.1 , pp. 15
    • Lamouille, S.1    Connolly, E.2    Smyth, J.W.3    Akhurst, R.J.4    Derynck, R.5
  • 63
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF-B-Induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille, S. and Derynck, R. (2007) Cell size and invasion in TGF-b-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J. Cell Biol. 178, 437 451
    • (2007) J. Cell Biol. , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2


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