Increased intestinal lipid absorption caused by ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein e-deficient mice

Circulation Research

Volumn 110, Issue 12, 2012, Pages 1575-1584

  Iqbal, Jahangir ^a   Queiroz, Joyce ^a   Li, Yan ^a   Jiang, Xian Cheng ^a   Ron, David ^b   Hussain, M Mahmood ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apolipoprotein B; Atherosclerosis; Cholesterol; Intestine; Lipid absorption

Indexed keywords

APOLIPOPROTEIN E; ENZYME; INOSITOL REQUIRING ENZYME 1BETA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; DIETARY INTAKE; ENZYME DEFICIENCY; HYPERLIPIDEMIA; INTESTINE ABSORPTION; LIPID ABSORPTION; LIPOPROTEIN SYNTHESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; DIETARY FATS; HYPERLIPIDEMIAS; INTESTINAL ABSORPTION; LIPID METABOLISM; MALE; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; UP-REGULATION;

EID: 84862271804     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.264283     Document Type: Article

References (34)

1. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ, National Heart, Lung, and Blood Institute, American College of Cardiology Foundation, American Heart Association. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004;110:227-239. (Pubitemid 38924592)
2. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation. 1979;60:473-485. (Pubitemid 9254048)
3. Lopez-Miranda J, Williams C, Lairon D. Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism. Br J Nutr. 2007;98:458-473. (Pubitemid 47272862)
4. Tomkin GH, Owens D. The chylomicron: relationship to atherosclerosis. Int J Vasc Med. 2012;2012:784536.
5. Karpe F. Postprandial lipoprotein metabolism and atherosclerosis. J Intern Med. 1999;246:341-355. (Pubitemid 29479916)
6. Proctor SD, Vine DF, Mamo JC. Arterial retention of apolipoprotein B(48)-and B(100)-containing lipoproteins in atherogenesis. Curr Opin Lipidol. 2002;13:461-470. (Pubitemid 35231925)
7. Proctor SD, Mamo JC. Retention of fluorescent-labelled chylomicron remnants within the intima of the arterial wall-evidence that plaque cholesterol may be derived from post-prandial lipoproteins. Eur J Clin Invest. 1998;28:497-503. (Pubitemid 28326416)
8. Alipour A, Elte JW, van Zaanen HC, Rietveld AP, Castro Cabezas M. Novel aspects of postprandial lipemia in relation to atherosclerosis. Atheroscler Suppl. 2008;9:39-44.
9. Veniant MM, Pierotti V, Newland D, Cham CM, Sanan DA, Walzem RL, Young SG. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest. 1997;100:180-188. (Pubitemid 27311256)
10. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol. 2000;2:326-332.
11. Bertolotti A, Wang X, Novoa I, Jungreis R, Schlessinger K, Cho JH, West AB, Ron D. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest. 2001;107:585-593. (Pubitemid 32205179)
12. Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. Nat Cell Biol. 2001;3:158-164. (Pubitemid 32118369)
13. Iqbal J, Dai K, Seimon T, Jungreis R, Oyadomari M, Kuriakose G, Ron D, Tabas I, Hussain MM. IRE1betal inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab. 2008;7:445-455. (Pubitemid 351598025)
14. Dai K, Khatun I, Hussain MM. NR2F1and IRE1beta suppress MTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cells. Arterioscler Thromb Vasc Biol. 2010;30:568-574.
15. Hussain MM, Rava P, Walsh M, Rana M, Iqbal J. Multiple functions of microsomal triglyceride transfer protein. Nutr Metab (Lond). 2012;9:14.
16. Hussain MM, Shi J, Dreizen.P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003;44:22-32. (Pubitemid 36114766)
17. Berriot-Varoqueaux N, Aggerbeck LP, Samson-Bouma M, Wetterau JR. The role of the microsomal triglygeride transfer protein in abetalipoproteinemia. Annu Rev Nutr. 2000;20:663-697.
18. Iqbal J, Anwar K, Hussain MM. Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J Biol Chem. 2003;278:31610-31620. (Pubitemid 37048339)
19. Anderson LJ, Boyles JK, Hussain MM. A rapid method for staining large chylomicrons. J Lipid Res. 1989;30:1819-1824. (Pubitemid 20024861)
20. Millar JS, Cromley DA, McCoy MG, Rader DJ, Billheimer JT. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res. 2005;46:2023-2028. (Pubitemid 41248500)
21. Iqbal J, Hussain MM. Evidence for multiple complementary pathways for efficient cholesterol absorption in mice. J Lipid Res. 2005;46:1491-1501. (Pubitemid 43109814)
22. Anwar K, Iqbal J, Hussain MM. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res. 2007;48:2028-2038. (Pubitemid 47360622)
23. Athar H, Iqbal J, Jiang XC, Hussain MM. A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein. J Lipid Res. 2004;45:764-772. (Pubitemid 38405684)
24. Rava P, Athar H, Johnson C, Hussain MM. Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein. J Lipid Res. 2005;46:1779-1785. (Pubitemid 41099346)
25. Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC. Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Circ Res. 2009;105:295-303.
26. Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest. 2006;116:1052-1062.
27. Pan X, Hussain MM. Diurnal regulation of microsomal triglyceride transfer protein and plasma lipid levels. J Biol Chem. 2007;282:24707-24719.
28. Pan X, Hussain MM. Clock is important for food and circadian regulation of macronutrient absorption in mice. J Lipid Res. 2009;50:1800-1813.
29. Pan X, Zhang Y, Wang L, Hussain MM. Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab. 2010;12:174-186.
30. Douglass JD, Malik N, Chon SH, Wells K, Zhou YX, Choi AS, Joseph LB, Storch J. Intestinal mucosal triacylglycerol accumulation secondary to decreased lipid secretion in obese and high fat fed mice. Front Physiol. 2012;3:25.
31. Fielding BA, Callow J, Owen RM, Samra JS, Matthews DR, Frayn KN. Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. Am J Clin Nutr. 1996;63:36-41. (Pubitemid 26005724)
32. Robertson MD, Parkes M, Warren BF, Ferguson DJ, Jackson KG, Jewell DP, Frayn KN. Mobilisation of enterocyte fat stores by oral glucose in humans. Gut. 2003;52:834-839. (Pubitemid 36613490)
33. Proctor SD, Mamo JC. Intimal retention of cholesterol derived from apolipoprotein B100-and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2003;23:1595-1600. (Pubitemid 37108203)
34. Pal S, Semorine K, Watts GF, Mamo J. Identification of lipoproteins of intestinal origin in human atherosclerotic plaque. Clin Chem Lab Med. 2003;41:792-795. (Pubitemid 36834124)