HLA-DRB1-DQA1-DQB1 genotype and frequency of enterovirus in longitudinal monthly fecal samples from healthy infants

Viral Immunology

Volumn 25, Issue 3, 2012, Pages 187-192

  Witsø, Elisabet ^a   Cinek, Ondrej ^b   Tapia, German ^a   Rasmussen, Trond ^a   Stene, Lars C ^a   Rønningen, Kjersti S ^c  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b CHARLES UNIVERSITY   (Czech Republic)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HLA DRB1 ANTIGEN; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; ENTEROVIRUS; ENTEROVIRUS INFECTION; FECES ANALYSIS; FEMALE; GENOTYPE; HAPLOTYPE; HIGH RISK POPULATION; HLA TYPING; HUMAN; HUMAN EXPERIMENT; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE INFECTION; LONGITUDINAL STUDY; MALE; NONHUMAN; NORMAL HUMAN; NORWAY; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR;

DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; ENTEROVIRUS INFECTIONS; FECES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HISTOCOMPATIBILITY TESTING; HLA-DQ ALPHA-CHAINS; HLA-DQ BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; INFANT; MALE;

EID: 84862269603     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2012.0001     Document Type: Article

References (34)

1. Pallansch MA, and Roos RP: Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Fields Virology, 5th ed. (Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, and Straus SE, eds.). Lippincott Williams & Wilkins, Philadelphia, 2007, pp. 839-894.
2. Bodian D: Emerging concept of poliomyelitis infection. Science 1955;122:105-108.
3. Witsø E, Cinek O, Aldrin M, et al.: Predictors of sub-clinical enterovirus infections in infants: a prospective cohort study. Int J Epidemiol 2010;39:459-468.
4. Undlien DE, Friede T, Rammensee HG, et al.: HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection. Diabetes 1997;46:143-149.
5. Van der Auwera B, Van WC, et al.: DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/ DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry. Diabetes 1995;44:527-530.
6. Thorsby E and Rønningen KS: Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1993;36:371-377. (Pubitemid 23124038)
7. Cinek O, Witsø E, Jeansson S, et al. Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes. J Clin Virol 2006;35:33-40. (Pubitemid 43020950)
8. Tauriainen S, Oikarinen S, Oikarinen M, and Hyöty H: Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol 2011;33:45-55.
9. Tracy S, Drescher KM, Jackson JD, Kim K, and Kono K: Enteroviruses, type 1 diabetes and hygiene: a complex relationship. Rev Med Virol 2010;20:106-116.
10. Ross ME, Onodera T, Brown KS, and Notkins AL: Virus-induced diabetes mellitus. IV. Genetic and environmental factors influencing the development of diabetes after infection with the M variant of encephalomyocarditis virus. Diabetes 1976;25:190-197.
11. Kruppenbacher JP, Mertens T, Muntefering H, and Eggers HJ: Encephalomyocarditis virus and diabetes mellitus: studies on virus mutants in susceptible and non-susceptible mice. J Gen Virol 1985;66(Pt 4):727-732. (Pubitemid 15113050)
12. Yoon JW, and Notkins AL: Virus-induced diabetes in mice. Metabolism 1983;32:37-40. (Pubitemid 13077647)
13. Blackwell JM, Jamieson SE, and Burgner D: HLA and infectious diseases. Clin Microbiol Rev 2009;22:370-385.
14. Graves PM, Norris JM, Pallansch MA, Gerling IC, and Rewers M: The role of enteroviral infections in the development of IDDM: limitations of current approaches. Diabetes 1997;46:161-168. (Pubitemid 27272247)
15. Craig ME, Howard NJ, Silink M, and Rawlinson WD: Reduced frequency of HLA DRB1*03-DQB1*02 in children with type 1 diabetes associated with enterovirus RNA. J Infect Dis 2003;187:1562-1570. (Pubitemid 36578962)
16. D'Alessio DJ: A case-control study of group B Coxsackievirus immunoglobulin M antibody prevalence and HLADR antigens in newly diagnosed cases of insulin-dependent diabetes mellitus. Am J Epidemiol 1992;135:1331-1338.
17. Eberhardt MS, Wagener DK, Orchard TJ, et al.: HLA heterogeneity of insulin-dependent diabetes mellitus at diagnosis. The Pittsburgh IDDM study. Diabetes 1985;34: 1247-1252. (Pubitemid 16186823)
18. Schernthaner G, Banatvala JE, Scherbaum W, et al.: Coxsackie-B-virus- specific IgM responses, complement-fixing islet-cell antibodies, HLA DR antigens, and C-peptide secretion in insulin-dependent diabetes mellitus. Lancet 1985; 2:630-632. (Pubitemid 15239336)
19. Sadeharju K, Knip M, Hiltunen M, Åkerblom HK, and Hyöty H: The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens. Diabetologia 2003;46:1100-1105. (Pubitemid 37041240)
20. Salminen K, Sadeharju K, Lönnrot M, et al.: Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study. J Med Virol 2003;69:91-98. (Pubitemid 35403659)
21. Stene LC, Oikarinen S, Hyöty H, et al.: Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 2010;59:3174-3180.
22. Fuchtenbusch M, Irnstetter A, Jager G, and Ziegler AG: No evidence for an association of coxsackie virus infections during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes. J Autoimmun 2001;17:333-340. (Pubitemid 34098417)
23. Oikarinen S, Martiskainen M, Tauriainen S, et al.: Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes 2011;60:276-279.
24. Sadeharju K, Hamalainen AM, Knip M, et al.: Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial. Clin Exp Immunol 2003; 132:271-277. (Pubitemid 36560623)
25. Stene LC, Witsø E, Torjesen PA, et al.: Islet autoantibody development during follow-up of high-risk children from the general Norwegian population from three months of age: design and early results from the MIDIA study. J Autoimmun 2007;29:44-51. (Pubitemid 47016915)
26. Pociot F and McDermott MF: Genetics of type 1 diabetes mellitus. Genes Immun 2002;3:235-249. (Pubitemid 38967549)
27. Bjørnvold M, Undlien DE, Joner G, et al.: Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. Diabetologia 2008;51:589-596.
28. Rønningen KS, Spurkland A, Iwe T, Vartdal F, and Thorsby E: Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus. Tissue Antigens 1991; 37:105-111.
29. Rønningen KS: Genetics in the prediction of insulin-dependent diabetes mellitus: from theory to practice. Ann Med 1997;29:387-392.
30. Khoury MJ and Flanders WD: Nontraditional epidemiologic approaches in the analysis of gene-environment interaction: case-control studies with no controls! Am J Epidemiol 1996;144:207-213. (Pubitemid 26313497)
31. Graves PM, Rotbart HA, Nix WA, et al.: Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY). Diabetes Res Clin Pract 2003;59:51-61. (Pubitemid 35461910)
32. Marttila J, Hyoty H, Nanto-Salonen K, Simell O, and Ilonen J: Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes. Virology 2004;319:27-35. (Pubitemid 38221052)
33. Steck AK, and Rewers MJ: Genetics of type 1 diabetes. Clin Chem 2011;57:176-185.
34. Singh R, Kaul R, Kaul A, and Khan K: A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol 2007;13: 1770-1787. (Pubitemid 46706009)