Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: A systematic review

Pediatric Blood and Cancer

Volumn 59, Issue 2, 2012, Pages 211-215

  Dekker, Louise H ^a,b   Fijnvandraat, Karin ^b   Brabin, Bernard J ^c   van Hensbroek, Michael Boele ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b EMMA CHILDREN S HOSPITAL   (Netherlands)

^c LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Growth; Infection; Micronutrients; Sickle cell disease; Vaso occlusive crisis

Indexed keywords

FOLIC ACID; OMEGA 3 FATTY ACID; TRACE ELEMENT; ZINC;

ARTICLE; BODY GROWTH; DIET SUPPLEMENTATION; GROWTH DISORDER; HUMAN; INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SICKLE CELL ANEMIA; SICKLE CELL CRISIS; SURVIVAL; SYSTEMATIC REVIEW; ZINC DEFICIENCY;

ANEMIA, SICKLE CELL; ARTERIAL OCCLUSIVE DISEASES; HUMANS; INFECTION; MICRONUTRIENTS;

EID: 84862263916     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.24163     Document Type: Article

References (35)

1. World Health Organization (WHO). Sickle-cell anaemia. Geneva, Switzerland: WHO; 2006.
2. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: An increasing global health problem. Bull World Health Organ 2001; 79: 704- 712.
3. Zemel BS, Kawchak DA, Ohene-Frempong K, et al. Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. Pediatr Res 2007; 61: 607- 613.
4. Cox SE, Makani J, Fulford AJ, et al. Nutritional status, hospitalization and mortality among patients with sickle cell anemia in tanzania. Haematologica 2011; 96: 948- 953.
5. Schall JI, Zemel BS, Kawchak DA, et al. Vitamin a status, hospitalizations, and other outcomes in young children with sickle cell disease. J Pediatr 2004; 145: 99- 106.
6. Sommer A, West KP. Vitamin a deficiency: Health, survival and vision. New York: Oxford University Press; 1996.
7. Al-Saqladi AWM, Cipolotti R, Fijnvandraat K, et al. Growth and nutritional status of children with homozygous sickle cell disease. Ann Trop Paediatr 2008; 28: 165- 189.
8. Wood KC, Granger DN. Sickle cell disease: Role of reactive oxygen and nitrogen metabolites. Clin Exp Pharmacol Physiol 2007; 34: 926- 932.
9. NHS Antenal and Newborn Screening Programmes. Sickle cell disease in childhood, standards and guidelines for clinical care. London, United Kingdom; 2007.
10. Ibidapo MO, Akinyanju OO. Acute sickle cell syndromes in nigerian adults. Clin Lab Haem 2000; 22: 151- 155.
11. Phebus CK, Maciak BJ, Gloninger MF, et al. Zinc status of children with sickle cell disease: Relationship to poor growth. Am J Hematol 1988; 29: 67- 73.
12. Julka RN, Aduli F, Lamps LW, et al. Ischemic duodenal ulcer, an unusual presentation of sickle cell disease. J Natl Med Assoc 2008; 100: 339- 341.
13. VanderJagt DJ, Kanellis GJ, Isichei C, et al. Serum and urinary amino acid levels in sickle cell disease. J Trop Pediatr 1997; 43: 220- 225.
14. Barden EM, Zemel BS, Kawchak DA, et al. Total and resting energy expenditure in children with sickle cell disease. J Pediatr 2000; 136: 73- 79.
15. National Institute of Health (NIH). Dietary supplement fact sheet: Folate. Website:
16. Shane B. Folic acid, vitamin b-12, and vitamin b-6. Stipanuk m, ed. Biochemical and physiological aspects of human nutrition. Philadelphia: W.B. Saunders Co; 2000. pp. 483- 518
17. Segal JB, Miller ER, Brereton NH, et al. Concentrations of b vitamins and homocysteine in children with sickle cell anemia. South Med J 2004; 97: 149- 155.
18. Westerman MP, Zhang Y, McConnell JP, et al. Ascorbate levels in red blood cells and urine in patients with sickle cell anemia. Am J Hematol 2000; 65: 174- 175.
19. Marwah SS, Blann AD, Rea C, et al. Reduced vitamin e antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis. Am J Hematol 2002; 69: 144- 146.
20. Rovner AJ, Stallings VA, Kawchak DA, et al. High risk of vitamin d deficiency in children with sickle cell disease. J Am Diet Assoc 2008; 108: 1512- 1516.
21. Zehtabchi S, Sinert R, Rinnert S, et al. Serum ionized magnesium levels and ionized calcium-to-magnesium ratios in adult patients with sickle cell anemia. Am J Hematol 2004; 77: 215- 222.
22. Glew RH, Casados JK, Huang YS, et al. The fatty acid composition of the serum phospholipids of children with sickle cell disease in nigeria. Prostaglandins Leukot Essent Fatty Acids 2002; 67: 217- 222.
23. Zemel BS, Kawchak DA, Fung EB, et al. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. Am J Clin Nutr 2002; 75: 300- 307.
24. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The prisma statement. PLoS Med 2009; 6: e1000097.
25. Junker C, Egger M, Schneider M, et al. The consort statement. JAMA 1996; 276: 1876- 1877.
26. Rabb LM, Grandison Y, Mason K. A trial of folate supplementation in children with homozygous sickle cell disease. Br J Haematol 1983; 54: 589- 594.
27. Tomer A, Kasey S, Connor WE, et al. Reduction of pain episodes and prothrombotic activity in sickle cell disease by dietary n-3 fatty acids. Thromb Haemost 2001; 85: 966- 974.
28. Bao B, Prasad AS, Beck FWJ, et al. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in sickle cell disease patients. Transl Res 2008; 152: 67- 80.
29. Gupta VL, Chaubey BS. Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: A double blind, randomized controlled clinical trial. J Assoc Physicians India 1995; 43: 467- 469.
30. Prasad AS, Beck FW, Kaplan J, et al. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (scd). Am J Hematol 1999; 61: 194- 202.
31. Moher D, Schulz KF, Altman DG. The consort statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001; 357: 1191- 1194.
32. Leonard MB, Zemel BS, Kawchak DA, et al. Plasma zinc status, growth, and maturation in children with sickle cell disease. J Pediatr 1998; 132: 467- 471.
33. Daeschner CW, Matustik MC, Carpentieri U, et al. Zinc and growth in patients with sickle cell disease. J Pediatr 1981; 98: 778- 780.
34. de Oliveira PMF, Povoa LC, Oliveira MHCF, et al. Study of zinc and growth hormone in sickle cell disease. J Pediatr Endocrinol Metab 2001; 14: 773- 779.
35. Finan AC, Elmer MA, Sasanow SR, et al. Nutritional factors and growth in children with sickle cell disease. Am J Dis Child 1988; 142: 237- 240.