NuMA overexpression in epithelial ovarian cancer

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Brüning Richardson, Anke ^a   Bond, Jaqueline ^a   Alsiary, Rawiah ^a   Richardson, Julie ^a   Cairns, David A ^a   McCormac, Luci ^a   Hutson, Richard ^b   Burns, Philip A ^a   Wilkinson, Nafisa ^b   Hall, Geoff D ^b   Morrison, Ewan E ^a   Bell, Sandra M ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b St James's Institute of Oncology   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR MITOTIC APPARATUS PROTEIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

AGE; ANEUPLOIDY; ARTICLE; ASCITES FLUID; CANCER CELL CULTURE; CANCER GRADING; CANCER INVASION; CANCER STAGING; CANCER TISSUE; CONTROLLED STUDY; CYTOKINESIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MICROARRAY ANALYSIS; MITOSIS SPINDLE; OVARY CARCINOMA; PROTEIN EXPRESSION; UPREGULATION;

ANTIGENS, NUCLEAR; CELL LINE; CELL SEPARATION; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS, GLANDULAR AND EPITHELIAL; NUCLEAR MATRIX-ASSOCIATED PROTEINS; OVARIAN NEOPLASMS;

EID: 84862249593     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038945     Document Type: Article

References (33)

1. Lydersen BK, Pettijohn DE, (1980) Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: distribution in a human/hamster hybrid cell. Cell 22: 489-499.
2. Merdes A, Ramyar K, Vechio JD, Cleveland DW, (1996) A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 87: 447-458.
3. Merdes A, Heald R, Samejima K, Earnshaw WC, et al. (2000) Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol 149: 851-862.
4. Peyre E, Jaouen F, Saadaoui M, Haren L, Merdes A, et al. (2011) A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells. J Cell Biol 193: 141-154.
5. Harborth J, Osborn M, (1999) Does NuMA have a scaffold function in the interphase nucleus? Crit Rev Eukaryot Gene Expr 9: 319-328.
6. Radulescu AE, Cleveland DW, (2010) NuMA after 30 years: the matrix revisited. Trends Cell Biol 20: 214-222.
7. Taimen P, Viljamaa M, Kallajoki M, (2000) Preferential expression of NuMA in the nuclei of proliferating cells. Exp Cell Res 256: 140-149.
8. Compton DA, Szilak I, Cleveland DW, (1992) Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol 116: 1395-1408.
9. Zeng C, He D, Brinkley BR, (1994) Localization of NuMA protein isoforms in the nuclear matrix of mammalian cells. Cell Motil Cytoskeleton 29: 167-176.
10. Holland AJ, Cleveland DW, (2009) Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 10: 478-487.
11. Thompson SJ, Backhoum SF, Compton DA, (2010) Mechanisms of chromosomal instability. Current Biology 20: R285-R295.
12. Cho KR, Shih IeM, (2009) Ovarian cancer. Annu Rev Pathol 4: 287-313.
13. Höglund M, Gisselsson D, Hansen GB, Säll T, Mitelman F, (2003) Ovarian carcinoma develops through multiple modes of chromosomal evolution. Cancer Res 63: 3378-3385.
14. Pothuri B, Leitao MM, Levine DA, Viale A, Olshen AB, et al. (2010) Genetic analysis of the early natural history of epithelial ovarian carcinoma. PLoS One 5: e10358.
15. Bayani J, Paderova J, Murphy J, Rosen B, Zielenska M, et al. (2008) Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer. Neoplasia 10: 1057-1065.
16. Sparks CA, Bangs PL, McNeil GP, Lawrence JB, Fey EG, (1993) Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13. Genomics 17: 222-224.
17. Brown LA, Kalloger SE, Miller MA, Shih leM, McKinney SE, et al. (2008) Amplification of 11q13 in ovarian carcinoma. Genes Chromosomes and Cancer 47: 481-489.
18. Brüning-Richardson A, Bond J, Richardson J, Alsiary R, Cairns DA, et al. (2011) ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival. Br J Cancer 104: 1602-1610.
19. Dynlacht JR, Roberts ZV, Earles M, Henthorn J, Seno JD, (2000) Different patterns of DNA fragmentation and degradation of nuclear matrix proteins during apoptosis induced by radiation, hyperthermia or etoposide. Radiation Res 154: 515-530.
20. Abad CA, Lewis J, Mian IS, Knowles DW, Sturgis J, et al. (2007) NuMA influences higher order chromatin organization in human mammary epithelium. Mol Biol Cell 18: 348-361.
21. Abd El-Rehim DM, Ball G, Pinder SE, Rakha E, Paish C, et al. (2005) High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 116: 340-350.
22. Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, et al. (2002) High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol 20: 2417-2428.
23. Gisselsson D, (2008) Classification of chromosome segregation errors in cancer. Chromosoma 117: 511-519.
24. Green RA, Kaplan KB, (2003) Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol 163: 949-961.
25. Bast RC Jr, Hennessy B, Mills GB, (2009) The biology of ovarian cancer: new opportunities for translation. Nature 9: 415-428.
26. Landen CN Jr, Birrer MJ, Sood AK, (2008) Early events in the pathogenesis of epithelial ovarian cancer. Journal of Clinical Oncology 26: 995-1005.
27. Parrella P, Zangen R, Sidransky D, Nicol T, (2003) Molecular analysis of peritoneal fluid in ovarian cancer patients. Mod Pathol 16: 636-640.
28. Ota J, Yamashita Y, Okawa K, Kisanuki H, Fujiwara S, et al. (2003) Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders. Oncogene 22: 5720-5728.
29. Vang R, Shih IeM, Kurman RJ, (2009) Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol 16: 267-282.
30. Quintyne NJ, Reing JE, Hoffelder DR, Gollin SM, Saunders WS, (2005) Spindle multipolarity is prevented by centrosomal clustering. Science 307: 127-129.
31. Landen CN Jr, Lin YG, Immaneni A, Deavers MT, Merritt WM, et al. (2007) Overexpression of the centrosomal protein Aurora-A kinase is associated with poor prognosis in epithelial ovarian cancer patients. Clin Cancer Res 13: 4098-4104.
32. Lassus H, Staff S, Leminen A, Isola J, Butzow R, (2011) Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma. Gynaecologic Oncology 120: 11-17.
33. Whitehurst AW, Xie Y, Purinton SC, Cappell KM, Swanik JT, et al. (2010) Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation. Cancer Res 70: 7652-7661.