Association between BDNF polymorphism (Val66Met) and executive function in patients with amnestic mild cognitive impairment or mild alzheimer disease

Dementia and Geriatric Cognitive Disorders

Volumn 33, Issue 4, 2012, Pages 266-272

  Nagata, Tomoyuki ^a,b   Shinagawa, Shunichiro ^a   Nukariya, Kazutaka ^b   Yamada, Hisashi ^a   Nakayama, Kazuhiko ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer disease; Brain derived neurotrophic factor; Executive function; Frontal Assessment Battery; Single nucleotide polymorphisms

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DNA; METHIONINE; VALINE;

AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; BRAIN FUNCTION; CLINICAL DEMENTIA RATING SCALE; DEMENTIA; DISEASE DURATION; DISEASE SEVERITY; FEMALE; FRONTAL ASSESSMENT BATTERY; GENOTYPE; HUMAN; JAPANESE; LEWY BODY; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; OUTPATIENT; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RATING SCALE; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE;

AGED; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; DISEASE PROGRESSION; EDUCATIONAL STATUS; EXECUTIVE FUNCTION; FEMALE; GENOTYPE; HUMANS; JAPAN; MALE; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC;

EID: 84862228882     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000339358     Document Type: Article

References (35)

1. Baudic S, Barba GD, Thibaudet MC, Smag-ghe A, Remy P, Traykov L: Executive function deficit in early Alzheimer's disease and their relations with episodic memory. Arch Clin Neuropsychol 2006;21: 15-21. (Pubitemid 41802923)
2. Perry RJ, Watson P, Hodge JR: The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: re-lationship to episodic and semantic memo-ry impairment. Neuropsychologia 2000;38: 252-271.
3. Buckner RL: Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004;44: 195-208. (Pubitemid 39348840)
4. Nagata T, Shinagawa S, Ochiai Y, Aoki R, Kasahara H, Nukariya K, Nakayama K: As-sociation between executive dysfunction and hippocampal volume in Alzheimer's disease. Int Psychogeriatr 2010;25: 1-8.
5. Yamao A, Nagata T, Shinagawa S, Nukariya K, Ochiai Y, Kasahara H, Nakayama K: Dif-ferentiation between amnestic-mild cogni-tive impairment and early-stage Alzheimer disease using the Frontal Assessment Bat-tery (FAB) test. Psychogeriatrics 2011;4: 235-241.
6. Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Good-kind M, Bell K, Stern Y, Devanand DP: Neu-ropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Arch Gen Psychiatry 2006;63: 916-924. (Pubitemid 44188484)
7. Nagata T, Ishii K, Ito T, Aoki K, Ehara Y, Kada H, Furukawa H, Tsumura M, Shinaga-wa S, Kasahara H, Nakayama K: Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease. Psychiatry Clin Neurosci 2009;63: 449-454.
8. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lind-say RM, Yancopoulos GD: NT-3, BDNF, and NGF in the developing rat nervous sys-tem: parallel as well as reciprocal patterns of expression. Neuron 1990;5: 501-509. (Pubitemid 20369586)
9. Aicardi G, Argilli E, Cappello S, Santi S, Ric-cio M, Thoenen H, Canossa M: Induction of long-term potentiation and depression is reflected by corresponding changes in se-cretion of endogenous brain-derived neuro-trophic factor. Proc Natl Acad Sci USA 2004; 101: 15788-15792. (Pubitemid 39473566)
10. Nagahara AH, Merrill DA, Coppola G, Tsu-kada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rocken-stein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH: Neu-roprotective effects of brain-derived neuro-trophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009;15: 331-337.
11. Poo MM: Neurotrophins as synaptic modu-lators. Nat Rev Neurosci 2001;2: 24-32.
12. Huang R, Huang J, Cathcart H, Smith S, Po-duslo SE: Genetic variants in brain-derived neurotrophic factor associated with Al-zheimer's disease. J Med Genet 2007;44: e66.
13. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR: Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associ-ations with substance abuse and Parkinsons disease. Am J Med Genet B Neuropsychiatr Genet 2005;134B: 93-103. (Pubitemid 40411118)
14. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS: Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and corti-cal neurons. J Neurosci 2004;24: 4401-4411. (Pubitemid 38608151)
15. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Wein-berger DR: The BDNF val66met polymor-phism affects activity-dependent secretion of BDNF and human memory and hippo-campal function. Cell 2003;112: 257-269. (Pubitemid 36144114)
16. Erickson KI, Kim JS, Suever BL, Voss MW, Francis BM, Kramer AF: Genetic contribu-tions to age-related decline in executive func-tion: a 10-year longitudinal study of COMT and BDNF polymorphisms. Front Hum Neurosci 2008;2: 11.
17. Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ: The brain-derived neurotrophic factor Val66Met poly-morphism is associated with age-related change in reasoning skills. Mol Psychiatry 2006;11: 505-513.
18. Voineskos AN, Lerch JP, Felsky D, Shaikh S, Rajji TK, Miranda D, Lobaugh NJ, Mulsant BH, Pollock BG, Kennedy JL: The brain-derived neurotrophic factor Val66Met poly-morphism and prediction of neural risk for Alzheimer disease. Arch Gen Psychiatry 2011;68: 198-206.
19. Nagata T, Shinagawa S, Nukariya K, Nakaya-ma R, Nakayama K, Yamada H: Association between nerve growth factor gene polymor-phism and executive dysfunction in Japa-nese patients with early-stage Alzheimer's disease and amnestic mild cognitive impair-ment. Dement Geriatr Cogn Disord 2012;32: 379-386.
20. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34: 939-944. (Pubitemid 14076461)
21. Petersen RC, Doody R, Kurz A: Current con-cepts in mild cognitive impairment. Arch Neurol 2001;58: 1985-1992. (Pubitemid 33143977)
22. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL: A new clinical scale for the stag-ing of dementia. Br J Psychiatry 1982;140: 566-572. (Pubitemid 12124384)
23. Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A: Behavioral symp-toms in Alzheimer's disease: phenomenol-ogy and treatment. J Clin Psychiatry 1987; 48(suppl): 9-15. (Pubitemid 17091427)
24. Nagata T, Shinagawa S, Nukariya K, Ochiai Y, Kawamura S, Agawa-Ohta M, Kasahara H, Nakayama K, Yamada H: Association between brain-derived neurotrophic factor (BDNF) gene polymorphisms and execu-tive function in Japanese patients with Al-zheimer's disease. Psychogeriatrics 2011;3: 141-149.
25. Dubois B, Slachevsky A, Litvan I, Pillon B: The FAB: a Frontal Assessment Battery at bedside. Neurology 2000;55: 1621-1626.
26. Folstein MF, Folstein SE, McHugh PR: 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12: 189-198.
27. Takagi R, Kajimoto Y, Kamiyoshi S, Miwa H, Kondo T: The frontal assessment battery at bedside (FAB) in patients with Parkin-son's disease (in Japanese). No Shinkei 2002; 54: 897-902. (Pubitemid 35416399)
28. Ventriglia M, Bocchio Chiavetto L, Benussi L, Binetti G, Zanetti O, Riva MA, Gennarelli M: Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 2002;7: 136-137. (Pubitemid 34177780)
29. Tsai SJ, Hong CJ, Liu HC, Liu TY, Liou YJ: The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a Chinese popula-tion. Dement Geriatr Cogn Disord 2006;21: 139-143.
30. Hanyu H, Sato T, Takasaki A, Akai T, Iwamoto T: Frontal lobe dysfunctions in subjects with mild cognitive impairment. J Neurol 2009; 256: 1570-1571.
31. Delbeuck X, Van der Linden M, Collette F: Alzheimer's disease as a disconnection syn-drome? Neuropsychol Rev 2003;13: 79-92.
32. Akatsu H, Yamagata HD, Kawamata J, Ka-mino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K Varia-tions in the BDNF gene in autopsy-con-firmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dement Geriatr Cogn Disord 2006;22: 216-222. (Pubitemid 44310517)
33. Iga J, Ueno S, Yamauchi K, Numata S, Tay-oshi-Shibuya S, Kinouchi S, Nakataki M, Song H, Hokoishi K, Tanabe H, Sano A, Ohmori T: The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and sui-cidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet 2007;144B: 1003-1006. (Pubitemid 350207773)
34. Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymor-phisms and Alzheimer's disease. J Neural Transm 2005;112: 703-711. (Pubitemid 40591202)
35. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, Waggoner SG, Tahl AR, Sklar P: Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry 2010;15: 810-815.