Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 100 B, Issue 5, 2012, Pages 1344-1352

  Kazemzadeh Narbat, Mehdi ^a   Noordin, Shahryar ^a   Masri, Bassam A ^a   Garbuz, Donald S ^a   Duncan, Clive P ^a   Hancock, Robert E W ^a   Wang, Rizhi ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antimicrobial peptide; Bone growth; Calcium phosphate coating; Orthopedic implants; Peri implant infection; Titanium

Indexed keywords

ABSORBANCE VALUES; ANTIBIOTIC-RESISTANT BACTERIA; ANTIMICROBIAL PEPTIDE; ANTIMICROBIAL PROPERTY; BONE GROWTH; BURST RELEASE; COLONY FORMING UNITS; CYTOTOXIC; DELIVERY SYSTEMS; DRUG RELEASE; IN-VITRO; IN-VITRO ASSAYS; IN-VIVO; INFECTION MODELS; JOINT ARTHROPLASTY; LOCAL DRUG DELIVERY; ORTHOPEDIC IMPLANT; OSSEOINTEGRATION; OSTEOBLAST-LIKE CELLS; OSTEOCONDUCTIVITY; PERI-IMPLANT INFECTIONS; POTENTIAL INHIBITION; PSEUDOMONAS AERUGINOSA; RABBIT MODELS; STAPHYLOCOCCUS AUREUS; TRABECULAR BONES;

BACTERIA; BONE; CALCIUM PHOSPHATE; DRUG DELIVERY; LOADING; PHOSPHATE COATINGS; TITANIUM;

CYTOTOXICITY;

CALCIUM PHOSPHATE; POLYPEPTIDE ANTIBIOTIC AGENT; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BIOCOMPATIBILITY; BONE GROWTH; CELL ADHESION; COLONY FORMING UNIT; CYTOTOXICITY; DRUG COATING; DRUG RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OSTEOBLAST; PSEUDOMONAS AERUGINOSA; RABBIT; SLOW DRUG RELEASE; SPECTROPHOTOMETRY; STAPHYLOCOCCUS AUREUS; TRABECULAR BONE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ARTHROPLASTY, REPLACEMENT, HIP; BONE REGENERATION; CALCIUM PHOSPHATES; CELL LINE, TUMOR; COATED MATERIALS, BIOCOMPATIBLE; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, BACTERIAL; HUMANS; MATERIALS TESTING; OSTEOBLASTS; PROSTHESES AND IMPLANTS; PSEUDOMONAS AERUGINOSA; RABBITS; STAPHYLOCOCCUS AUREUS; TITANIUM;

EID: 84862218354     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.32701     Document Type: Article

References (47)

1. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery -Prophylaxis and treatment. Drugs 2006;66:1089-1105. (Pubitemid 43945869)
2. Trampuz A, Widmer AF. Infections associated with orthopedic implants. Curr Opin Infect Dis 2006;19:349-356. (Pubitemid 43982507)
3. Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: Its production and regulation. Int J Artif Organs 2005;28:1062-1068. (Pubitemid 43085399)
4. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: A common cause of persistent infections. Science 1999;284:1318-1322. (Pubitemid 29289651)
5. Donlan RM, Costerton JW. Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 2002;15:167-193. (Pubitemid 34303762)
6. Rogers SS, van der Walle C, Waigh TA. Microrheology of bacterial biofilms in vitro: Staphylococcus aureus and Pseudomonas aeruginosa. Langmuir 2008;24:13549-13555.
7. Lyczak JB, Cannon CL, Pier GB. Establishment of Pseudomonas aeruginosa infection: Lessons from a versatile opportunist. Microbes Infect 2000;2:1051-1060. (Pubitemid 30664219)
8. Rao NL, Ziran BH, Lipsky BA. Treating osteomyelitis: Antibiotics and surgery. Plast Reconstr Surg 2011;127:177S-187S.
9. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004;351:1645-1654.
10. Kazemzadeh-Narbat M, Kindrachuk J, Duan K, Jenssen H, Hancock REW, Wang R. Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections. Biomaterials 2010;31:9519-9526.
11. Lauderdale KJ, Malone CL, Boles BR, Morcuende J, Horswill AR. Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. J Orthop Res 2010;28:55-61.
12. Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med 2004;350:1422-1429. (Pubitemid 38419996)
13. Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC. Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res 2011;29:1070-1074.
14. Zhao L, Chu PK, Zhang Y, Wu Z. Antibacterial coatings on titanium implants. J Biomed Mater Res B Appl Biomater 2009;91:470-480.
15. Francolini I, Donelli G. Prevention and control of biofilm-based medical-device-related infections. FEMS Immunol Med Microbiol 2010;59:227-238.
16. Rotem S, Mor A. Antimicrobial peptide mimics for improved therapeutic properties. Biochim Biophys Acta 2009;1788:1582-1592.
17. Yeaman MR, Yount NY. Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev 2003;55:27-55. (Pubitemid 36268398)
18. Hancock REW, Lehrer R. Cationic peptides: A new source of antibiotics. Trends Biotechnol 1998;16:82-88. (Pubitemid 28055477)
19. Hilpert K, Volkmer-Engert R, Walter T, Hancock REW. Highthroughput generation of small antibacterial peptides with improved activity. Nat Biotech 2005;23:1008-1012. (Pubitemid 41114036)
20. Jenssen H, Hamill P, Hancock REW. Peptide antimicrobial agents. Clin Microbiol Rev 2006;19:491-511. (Pubitemid 44137212)
21. Brogden KA. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 2005;3:238-250. (Pubitemid 40298223)
22. Gidalevitz D, Ishitsuka Y, Muresan AS, Konovalov O, Waring AJ, Lehrer RI, et al. Interaction of antimicrobial peptide protegrin with biomembranes. Proc Natl Acad Sci USA 2003;100:6302-6307. (Pubitemid 36666576)
23. Madera L, Ma S, Hancock REW. Host defense (antimicrobial) peptides and proteins. In Kaufmann, S.H.E., B. Rouse, and D. Sacks, eds. ASM Press, Washington, DC. The Immune Response Infect 2011:57-67.
24. Liu S, Yang H, Wan L, Cai H-W, Li S-F, Li Y-P, et al. Enhancement of cytotoxicity of antimicrobial peptide magainin II in tumor cells by bombesin-targeted delivery. Acta Pharmacol Sin 2011;32:79-88.
25. Gao G, Lange D, Hilpert K, Kindrachuk J, Zou Y, Cheng JTJ, et al. The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides. Biomaterials 2011;32:3899-3909.
26. Fan YW, Duan K, Wang RZ. A composite coating by electrolysisinduced collagen self-assembly and calcium phosphate mineralization. Biomaterials 2005;26:1623-1632. (Pubitemid 39585167)
27. Garbuz DS, Hu Y, Kim WY, Duan K, Masri BA, Oxland TR, et al. Enhanced gap filling and osteoconduction associated with alendronate-calcium phosphate-coated porous tantalum. J Bone Joint Surg Am 2008;90:1090-1100. (Pubitemid 351632654)
28. Fjell CD, Jenssen H, Hilpert K, Cheung WA, Pante N, Hancock REW, et al. Identification of novel antibacterial peptides by chemoinformatics and machine learning. J Med Chem 2009;52:2006-2015.
29. Cherkasov A, Hilpert K, Jenssen Hv, Fjell CD, Waldbrook M, Mullaly SC, et al. Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem Biol 2008;4:65-74.
30. Pace CN, Vajdos F, Fee L, Grimsley G, Gray T. Howtomeasure and predict the molar absorption-coefficient of a pretein. Protein Sci 1995;4:2411-2423.
31. Delhaye S, Landry J. High-performance liquid chromatography and ultraviolet spectrophotometry for quantitation of tryptophan in barytic hydrolysates. Anal Biochem 1986;159:175-178. (Pubitemid 17228242)
32. Thomas W. Bauer DM. Handbook of Histology Methods for Bone and Cartilage. Totowa, New Jersey: Humana Press; 2003.
33. Brown K, Li B, Guda T, Guelcher S, Wenke J. Local antibiotics do not inhibit bone growth when administered with growth factro. J Bone Joint Surg Br B 2011;93:100.
34. Woods AS, Ferre S. Amazing stability of the arginine-phosphate plectrostatic interaction. J Proteome Res 2005;4:1397-1402. (Pubitemid 41208697)
35. Wu P, Grainger DW. Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials 2006;27: 2450-2467. (Pubitemid 41821824)
36. Gerhart TN, Roux RD, Horowitz G, Miller RL, Hanff P, Hayes WC. Antibiotic release from an experimental biodegradable bonecement. J Orthop Res 1988;6:585-592.
37. Joosten U, Joist A, Gosheger G, Liljenqvist U, Brandt B, von Eiff C. Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis. Biomaterials 2005;26:5251-5258. (Pubitemid 40387847)
38. Schnieders J, Gbureck U, Thull R, Kissel T. Controlled release of gentamicin from calcium phosphate-poly(lactic acid-co-glycolic acid) composite bone cement. Biomaterials 2006;27:4239-4249. (Pubitemid 44294361)
39. Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Korner J, et al. Screening and characterization of surface-tethered cationic peptides for antimicrobial activity. Chem Biol 2009;16:58-69.
40. Glukhov E, Stark M, Burrows LL, Deber CM. Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes. J Biol Chem 2005;280:33960-33967. (Pubitemid 41443116)
41. Mello Charlene M, Soares Jason W. Membrane selectivity of antimicrobial peptides. Microbial Surfaces ACS 2008;984:52-62.
42. Stallmann HP, de Roo R, Faber C, Amerongen AVN, Wuisman P. In vivo release of the antimicrobial peptide hLF1-11 from calcium phosphate cement. J Orthop Res 2008;26:531-528.
43. Faber C, Stallmann HP, Lyaruu DM, Joosten U, von Eiff C, Amerongen AV, et al. Comparable efficacies of the antimicrobial peptide human lactoferrin 1-11 and gentamicin in a chronic methicillin-resistant Staphylococcus aureus osteomyelitis model. Antimicrob Agents Chemother 2005;49:2438-2444. (Pubitemid 40734477)
44. Hancock REW. Cationic peptides: Effectors in innate immunity and novel antimicrobials. Lancet Infect Dis 2001;1:156-164.
45. Gough M, Hancock R, Kelly N. Antiendotoxin activity of cationic peptide antimicrobial agents. Infect Immun 1996;64:4922-4927. (Pubitemid 26403942)
46. Chang YL, Stanford CM, Wefel JS, Keller JC. Osteoblastic cell attachment to hydroxyapatite-coated implant surfaces in vitro. Int J Oral Maxillofac Implants 1999;14:239-247.
47. Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF. Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials 2001;22:87-96.