Modulation of Th1/Th2 cytokine production by selective and nonselective phosphodiesterase inhibitors administered to mice

Pharmacological Reports

Volumn 64, Issue 1, 2012, Pages 179-184

  Szczypka, Marianna ^a   Ploch, Sebastian ^a   Obmińska Mrukowicz, Bozena ^a  

^a WROCLAW UNIVERSITY OF ENVIRONMENTAL AND LIFE SCIENCES   (Poland)

Author keywords

Aminophylline; Milrinone; Sildenafil; T lymphocytes; Th1 Th2 cytokines

Indexed keywords

AMINOPHYLLINE; AMINOPHYLLINUM; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MILRINONE; SILDENAFIL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIVITY; FEMALE; IMMUNOMODULATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; SINGLE DRUG DOSE; TH1 TH2 BALANCE;

EID: 84862214447     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(12)70744-2     Document Type: Article

References (27)

1. Aricha R, Feferman T, Souroujon MC, Fuchs S: Overexpression of phosphodiesterases in experimental autoimmune myasthenia gravis: suppression of disease by a phosphodiesterase inhibitor. FASEB J, 2006, 20, 374-376. (Pubitemid 46671176)
2. Bielekova B, Lincoln A, McFarland H, Martin R: Therapeutic potential of phosphodiesterase-4 and -3 inhibitors in Th1-mediated autoimmune diseases. J Immunol, 2000, 164, 1117-1124. (Pubitemid 30043742)
3. Caramori G, Groneberg D, Ito K, Casolari P, Adcock IM, Papi A: New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol, 2008, 3, Suppl. 1, S6.
4. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR: Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med, 1987, 166, 1229-1244. (Pubitemid 18051419)
5. Crocker IC, Townley RG, Khan MM: Phosphodiesterase inhibitors suppress proliferation of peripheral blood mononuclear cells and interleukin-4 and -5 secretion by human T-helper type 2 cells. Immunopharmacology, 1996, 31, 223-235. (Pubitemid 26122650)
6. Dinter H, Tse J, Halks-Miller M, Asarnow D, Onuffer J, Faulds D, Mitrovic B et al.: The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents. J Neuroimmunol, 2000, 108, 136-146. (Pubitemid 30438761)
7. Essayan DM, Huang SK, Kagey-Sobotka A, Lichtenstein LM: Differential efficacy of lymphocyte- and monocyteselective pretreatment with a type 4 phosphodiesterase inhibitor on antigen-driven proliferation and cytokine gene expression. J Allergy Clin Immunol, 1997, 99, 28-37. (Pubitemid 27074894)
8. Essayan DM, Huang SK, Undem BJ, Kagey-Sobotka A, Lichtenstein LM: Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Immunol, 1994, 153, 3408-3416.
9. Essayan DM, Kagey-Sobotka A, Lichtenstein LM, Huang SK: Differential regulation of human antigen-specific Th1 and Th2 lymphocyte response by isozyme selective cyclic nucleotide phosphodiesterase inhibitors. J Pharmacol Exp Ther, 1997, 282, 505-512. (Pubitemid 27425580)
10. Fan Chung K: Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol, 2006, 8, 533, 110-117.
11. Gantner F, Kusters S, Wendel A, Hatzelmann A, Schudt C, Tiegs G.: Protection from T cell-mediated murine liver failure by phosphodiesterase inhibitors. J Pharmacol Exp Ther, 1997, 280, 53-60. (Pubitemid 27171387)
12. Giembycz MA, Corrigan CJ, Seybold J, Newton R, Barnes PJ: Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br J Pharmacol, 1996, 118, 1945-1958. (Pubitemid 26292562)
13. Halpin D: ABCD of the phosphodiesterase family: interaction and differential activity in COPD. Int J Chron Obstruct Pulmon Dis, 2008, 3, 543-561.
14. Hidi R, Timmermans S, Liu E, Schudt C, Dent G, Holgate ST, Djukanovic R: Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis. Eur Respir J, 2000, 15, 342-349. (Pubitemid 30085964)
15. Kurt-Jones EA, Hamberg S, Ohara J, Paul WE, Abbas AK: Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med, 1987, 166, 1774-1787. (Pubitemid 18000354)
16. Lin CC, Lin CY, Liaw SF, Chen A: Pulmonary function changes and immunomodulation of Th 2 cytokine expression induced by aminophylline after sensitization and allergen challenge in brown Norway rats. Ann Allergy Asthma Immunol, 2002, 88, 215-222.
17. Manning CD, Burman M, Christensen SB, Cieslinski LB, Essayan DM, Grous M, Torphy TJ, Barnette MS: Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br J Pharmacol, 1999, 128, 1393-1398.
18. Mauri C, Feldmann M, Williams RO: Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response. Arthritis Rheum, 2003, 48, 839-845. (Pubitemid 36302023)
19. Mauri C, Williams RO, Walmsley M, Feldmann M: Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur J Immunol, 1996, 26, 1511-1518. (Pubitemid 26229996)
20. Rieneck K, Diamant M, Haahr P-M, Schonharting M, Bendtzen K: In vitro immunomodulatory effects of pentoxifylline. Immunol Lett, 1993, 37, 131-138. (Pubitemid 23303726)
21. Rott O, Cash E, Fleischer B: Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats. Eur J Immunol, 1993, 23, 1745-1751. (Pubitemid 23236761)
22. Schmidt J, Hatzelmann A, Fleissner S, Heimann- Weitschat I, Lindstaedt R, Szelenyi I: Effect of phosphodiesterase inhibition on IL-4 and IL-5 production of the murine TH2-type T cell clone D10.G4.1. Immunopharmacology, 1995, 30, 191-198.
23. Stam WB, Van Oosterhout AJ, Nijkamp FP: Pharmacologic modulation of Th1- and Th2-associated lymphokine production. Life Sci, 1993, 53, 1921-1934.
24. Suresh R, Vig M, Bhatia S, Goodspeed EP, John B, Kandpal U, Srivastava S et al.: Pentoxifylline functions as an adjuvant in vivo to enhance T cell immune responses by inhibiting activation-induced death. J Immunol, 2002, 169, 4262-4272. (Pubitemid 35178198)
25. Tenor H, Staniciu L, Schudt C, Hatzelmann A, Wendel A, Djukanovic R, ChurchMK, Shute JK: Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes. Clin Exp Allergy, 1995, 25, 616-624.
26. Torphy TJ: Phosphodiesterase isozymes. Molecular targets for novel antiasthma agents. Am J Respir Crit Care Med, 1998, 157, 351-370.
27. Yoshimura T, Nagao T, Nakao T, Watanabe S, Usami E, Kobayashi J, Yamazaki F et al.: Modulation of Th1- and Th2-like cytokine production from mitogen-stimulated human peripheral blood mononuclear cells by phosphodiesterase inhibitors. Gen Pharmacol, 1998, 30, 175-180. (Pubitemid 28026718)